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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Rou Gui (Cinnamomum cassia bark) is a traditional medicinal herb used for its anti-diabetic, anti-inflammatory, and antibacterial properties [PMID:38688144, 34408931, 36255521].
Contexte
Cinnamomum cassia Presl, also known as Chinese cinnamon or cassia, is a member of the Lauraceae family used as a spice and in traditional medicine [PMID:38308239, 26873449]. It is distinct from Ceylon cinnamon (Cinnamomum verum) and contains high amounts of coumarin [PMID:40986675].
Usages traditionnels
Historically used in traditional Chinese medicine (recorded in 'Shennong's Herbal Classic') to treat respiratory diseases, inflammation [PMID:38688144], cardiovascular diseases [PMID:26119954], and rheumatoid arthritis [PMID:30591891]. It has also been used in Ayurvedic and folk medicine as a galactogogue [PMID:40986675].
Composés actifs
Major components include cinnamaldehyde [PMID:36255521, 10554188], coumarin, cinnamyl alcohol, cinnamic acid, and various terpenoids [PMID:26873449, 38308239]. Other identified compounds include syringaresinol (a lignan) [PMID:40780474], a purified polysaccharide (CCP1A) [PMID:42282441], and procyanidin oligomers such as cinnamtannin D1 [PMID:25530780].
Mécanisme d'action
C. cassia bark essential oil may ameliorate acute lung injury by regulating macrophage polarization through the TLR4/MyD88/NF-κB pathway [PMID:38688144]. Syringaresinol may ameliorate cognitive deficits via AMPK activation [PMID:40780474]. It has also been shown to inhibit platelet-derived growth factor (PDGF)-BB-induced vascular smooth muscle cell proliferation by up-regulating cyclin-dependent kinase inhibitors p21 and p27 [PMID:26119954].
Preuves cliniques
Preuve BType 2 Diabetes / Elevated Serum Glucose
A placebo-controlled double-blind trial of a spray-dried water extract (250 mg twice daily for two months) showed beneficial effects on circulating glucose, lipids, and insulin [PMID:27774415]. A systematic review and meta-analysis evaluated the impact of 1-2 gm/day of ground bark powder for 90 days on plasma glucose and lipids [PMID:34408931].
Sécurité et effets indésirables
Generally well tolerated, though occasional bloating, dyspepsia, heartburn, and nausea are reported [PMID:40986675]. High doses in animal models (5000 mg/kg BW) showed significant elevation of AST, ALT, ALP, urea, and creatinine [PMID:33849352]. It contains coumarin, which is described as a toxic ingredient [PMID:40986675].
Grossesse et allaitement
No data exist on the safety of cinnamon in nursing mothers or infants [PMID:40986675].
Synthèse des preuves
Evidence consists primarily of in vitro and animal studies (D) and a limited number of human clinical trials and systematic reviews (A, B) focusing on glycemic control.
Sources PubMed
1.PMID: 40986675 (2006) — Anti-diabetic nephropathy compounds from Cinnamomum cassia. · Journal of ethnopharmacology
2.PMID: 34408931 (2021) — Impact of Cassia Bark Consumption on Glucose and Lipid Control in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis. · Cureus
3.PMID: 33849352 (2022) — Acute toxicity studies and protective effects of Cinnamon cassia bark extract in streptozotocin-induced diabetic rats. · Drug and chemical toxicology
4.PMID: 38688144 (2024) — Essential oil from Cinnamomum cassia Presl bark regulates macrophage polarization and ameliorates lipopolysaccharide-induced acute lung injury through TLR4/MyD88/NF-κB pathway. · Phytomedicine : international journal of phytotherapy and phytopharmacology
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— Anti-diabetic and hypolipidemic effects of Cinnamon cassia bark extracts: an in vitro, in vivo, and in silico approach.
· Archives of physiology and biochemistry
6.PMID: 42282441 (2026) — Structural Characterization and Hypoglycemic Effects of a Purified Polysaccharide From Cinnamomum cassia. · Food science & nutrition
7.PMID: 40780474 (2025) — Syringaresinol from Cinnamomum cassia (L.) J.Presl ameliorates cognitive deficits and AD pathology via AMPK in a DM-AD mouse model. · Journal of ethnopharmacology
8.PMID: 15934022 (2005) — Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro. · Phytotherapy research : PTR
9.PMID: 36255521 (2022) — Antibacterial activity of essential oils extracted from the unique Chinese spices cassia bark, bay fruits and cloves. · Archives of microbiology
10.PMID: 38308239 (2024) — Integrated transcriptomics and metabolomics analysis provides insights into aromatic volatiles formation in Cinnamomum cassia bark at different harvesting times. · BMC plant biology
11.PMID: 39495857 (2024) — Barks and leaves of Lauraceae plants as anti-acne. · Pakistan journal of pharmaceutical sciences
12.PMID: 36219334 (2023) — Critical Review on Nutritional, Bioactive, and Medicinal Potential of Spices and Herbs and Their Application in Food Fortification and Nanotechnology. · Applied biochemistry and biotechnology
13.PMID: 40405160 (2025) — Investigating the potential scabicidal activities of three essential oils: gaining mechanistic insights through in vitro contact bioassay and molecular docking. · BMC complementary medicine and therapies
14.PMID: 26151013 (2015) — Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer's disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities. · Journal of traditional and complementary medicine
15.PMID: 38899851 (2024) — Antileishmanial and Antifungal Activities of Volatile Oils from Cinnamomum Cassia Bark and Schinus Molle Leaves. · Chemistry & biodiversity
16.PMID: 10554188 (1998) — Growth-Inhibiting Effects of Cinnamomum cassia Bark-Derived Materials on Human Intestinal Bacteria. · Journal of agricultural and food chemistry
17.PMID: 30591891 (2018) — Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models. · Integrative medicine research
18.PMID: 31751643 (2020) — FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
19.PMID: 29482462 (2018) — In vitro inhibition of food borne mutagens induced mutagenicity by cinnamon (Cinnamomum cassia) bark extract. · Drug and chemical toxicology
20.PMID: 26873449 (2016) — Differentiating parts of Cinnamomum cassia using LC-qTOF-MS in conjunction with principal component analysis. · Biomedical chromatography : BMC
21.PMID: 25530780 (2014) — Immunosuppressive Effects of A-Type Procyanidin Oligomers from Cinnamomum tamala. · Evidence-based complementary and alternative medicine : eCAM
22.PMID: 29804253 (2018) — Supercritical carbon dioxide extract of Cinnamomum cassia bark: toxicity and repellency against two stored-product beetle species. · Environmental science and pollution research international
23.PMID: 32573270 (2020) — Cinnamomum cassia ameliorates Ni-NPs-induced liver and kidney damage in male Sprague Dawley rats. · Human & experimental toxicology
24.PMID: 37687133 (2023) — Analysis of the Antibacterial Properties of Compound Essential Oil and the Main Antibacterial Components of Unilateral Essential Oils. · Molecules (Basel, Switzerland)
25.PMID: 27774415 (2016) — Cinnamon extract lowers glucose, insulin and cholesterol in people with elevated serum glucose. · Journal of traditional and complementary medicine
26.PMID: 37450504 (2023) — Short communication: Antibacterial effects of essential oils from Cinnamomum cassia bark and Eucalyptus globulus leaves-The involvements of major constituents. · PloS one
27.PMID: 26119954 (2015) — Cinnamon and its Components Suppress Vascular Smooth Muscle Cell Proliferation by Up-Regulating Cyclin-Dependent Kinase Inhibitors. · The American journal of Chinese medicine