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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Salvia divinorum
Mexican sage sacred to Mazatec shamans; leaves contain salvinorin A - most potent natural hallucinogen.
Salvia divinorum is a psychoactive Mexican sage traditionally used by Mazatec shamans for divination and visionary ceremonies. Its primary active compound, salvinorin A, is the most potent naturally occurring hallucinogen, acting as a selective kappa-opioid receptor agonist. Modern research explores its use in psychedelic therapy and as a tool for studying consciousness, though evidence remains limited.
Salvinorin A exerts its effects primarily through potent and selective agonism at the kappa-opioid receptor (KOR), a G protein-coupled receptor distinct from the mu-opioid receptor targeted by classical opioids. Activation of KOR leads to dysphoria, dissociation, and altered perception via modulation of downstream signaling pathways including MAPK and inhibition of adenylyl cyclase. Unlike classical psychedelics, it does not interact with serotonin 5-HT2A receptors, and its effects are short-lived due to rapid metabolism by esterases. Other compounds like salvinorin B and divinatorins may modulate the overall activity but are less potent.
Mexican sage sacred to Mazatec shamans; leaves contain salvinorin A - most potent natural hallucinogen.
Salvia divinorum is a psychoactive Mexican sage traditionally used by Mazatec shamans for divination and visionary ceremonies. Its primary active compound, salvinorin A, is the most potent naturally occurring hallucinogen, acting as a selective kappa-opioid receptor agonist. Modern research explores its use in psychedelic therapy and as a tool for studying consciousness, though evidence remains limited.
Salvinorin A exerts its effects primarily through potent and selective agonism at the kappa-opioid receptor (KOR), a G protein-coupled receptor distinct from the mu-opioid receptor targeted by classical opioids. Activation of KOR leads to dysphoria, dissociation, and altered perception via modulation of downstream signaling pathways including MAPK and inhibition of adenylyl cyclase. Unlike classical psychedelics, it does not interact with serotonin 5-HT2A receptors, and its effects are short-lived due to rapid metabolism by esterases. Other compounds like salvinorin B and divinatorins may modulate the overall activity but are less potent.