Loading...
Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Loading...
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Sanguinaria canadensis
Native North American herb with red sap used by Indigenous peoples for respiratory conditions and topically for skin growths.
Sanguinaria canadensis, a North American herb with distinctive red sap, has traditional use in Native American medicine for respiratory conditions and as a topical escharotic. Modern research focuses on its antimicrobial and antiplaque properties, primarily attributed to the alkaloid sanguinarine, with emerging interest in antitumor applications. Key active compounds include sanguinarine, chelerythrine, berberine, and protopine.
Sanguinarine, a benzophenanthridine alkaloid, exerts antimicrobial effects by intercalating DNA and inhibiting bacterial topoisomerase I and II, leading to cell death. It also inhibits NF-κB signaling and induces apoptosis in cancer cells via mitochondrial pathways and reactive oxygen species generation. Chelerythrine acts as a protein kinase C inhibitor, contributing to anti-inflammatory and pro-apoptotic effects. Berberine activates AMPK and modulates gut microbiota, while protopine exhibits antispasmodic and antiarrhythmic properties through calcium channel blockade.
Native North American herb with red sap used by Indigenous peoples for respiratory conditions and topically for skin growths.
Sanguinaria canadensis, a North American herb with distinctive red sap, has traditional use in Native American medicine for respiratory conditions and as a topical escharotic. Modern research focuses on its antimicrobial and antiplaque properties, primarily attributed to the alkaloid sanguinarine, with emerging interest in antitumor applications. Key active compounds include sanguinarine, chelerythrine, berberine, and protopine.
Sanguinarine, a benzophenanthridine alkaloid, exerts antimicrobial effects by intercalating DNA and inhibiting bacterial topoisomerase I and II, leading to cell death. It also inhibits NF-κB signaling and induces apoptosis in cancer cells via mitochondrial pathways and reactive oxygen species generation. Chelerythrine acts as a protein kinase C inhibitor, contributing to anti-inflammatory and pro-apoptotic effects. Berberine activates AMPK and modulates gut microbiota, while protopine exhibits antispasmodic and antiarrhythmic properties through calcium channel blockade.