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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Saraphi (Mammea siamensis) is a Thai medicinal plant known for its bioactive coumarins and xanthones, which demonstrate antiproliferative and antimalarial activities in laboratory models [PMID:25738951, 36224571, 37259379].
Contexte
Mammea siamensis, also known as Saraphi, is a medicinal plant from the Calophyllaceae family used in traditional Thai medicine [PMID:25738951, 28573218, 36224571].
Usages traditionnels
It is used in traditional Thai medicine [PMID:25738951, 28573218] and is a component of the 'Poh-Pu' remedy for cancer therapy [PMID:34953977], the 'Kheaw Hom' remedy for fever [PMID:37143036], and the 'Sa-Tri-Lhung-Klod' remedy used for postpartum care, amenorrhea, menopause, and as a blood tonic [PMID:25518307].
Composés actifs
The plant contains various coumarins (including mammea E/BB, mammeasins A-Q, kayeassamins A-G, and surangins B-D) [PMID:25738951, 12027761, 32266216, 37259379, 33246033, 21048341], xanthones (such as 1-hydroxy-5,6,7-trimethoxyxanthone) [PMID:9612959, 38521901, 21048341], and flavonoids like vitexin and isovitexin [PMID:38601576].
Mécanisme d'action
Mammea E/BB down-regulates Wilms' tumour 1 (WT1) expression by disrupting transcriptional auto-regulation rather than through protein or mRNA degradation [PMID:27193767]. Other mechanisms include the inhibition of testosterone 5α-reductase [PMID:32266216], competitive inhibition of aromatase [PMID:36232534], and induction of apoptosis via activation of Caspase-3/-8 [PMID:27695262] or inhibition of Vacuolar-Type H+-ATPase associated with GSK-3β/β-Catenin, PI3K/Akt/NF-κB, and MAPK signaling pathways [PMID:40283879].
Preuves cliniques
Preuve DLeukemia (K562, Molt4, HL-60 cells)
Extracts and compounds (e.g., mammea E/BB, kayeassamin A) showed cytotoxic effects and decreased WT1 and Bcr/Abl protein expression [PMID:25738951, 28573218, 27695262].
Preuve DMalaria (P. falciparum, P. berghei)
Hexane and dichloromethane extracts showed potent antimalarial activity in vitro [PMID:36224571]; 1-hydroxy-5,6,7-trimethoxyxanthone demonstrated in vivo antimalarial activity in mouse models [PMID:38521901].
Methanol flower extracts and specific coumarins (e.g., mammeasins A, B, E/BC) exhibited anti-proliferative activity against LNCaP, HCT116, and other cancer cell lines [PMID:37259379, 40283879, 33246033, 21048341].
Preuve DEnteric Bacteria
Ethanolic flower extracts were investigated for antibacterial properties against E. coli, S. Typhi, S. dysenteriae, and V. cholerae [PMID:41148731].
Sécurité et effets indésirables
Acute toxicity studies of 1-hydroxy-5,6,7-trimethoxyxanthone in mice included examinations of liver and kidney functions and histopathology [PMID:38521901].
Synthèse des preuves
The current evidence consists entirely of in vitro cell culture studies and in vivo animal models (Level D). There are no human clinical trials provided in the source material.
Sources PubMed
1.PMID: 25738951 (2016) — Inhibitory effect of mammea E/BB from Mammea siamensis seed extract on Wilms' tumour 1 protein expression in a K562 leukaemic cell line. · Natural product research
2.PMID: 12027761 (2002) — Mammea coumarins from the flowers of Mammea siamensis. · Journal of natural products
3.PMID: 28573218 (2017) — EFFECT OF THAI SARAPHI FLOWER EXTRACTS ON WT1 AND BCR/ABL PROTEIN EXPRESSION IN LEUKEMIC CELL LINES. · African journal of traditional, complementary, and alternative medicines : AJTCAM
4.PMID: 32266216 (2020) — Geranylated Coumarins From Thai Medicinal Plant Mammea siamensis With Testosterone 5α-Reductase Inhibitory Activity. · Frontiers in chemistry
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— Down-regulatory mechanism of mammea E/BB from Mammea siamensis seed extract on Wilms' Tumor 1 expression in K562 cells.
· BMC complementary and alternative medicine
6.PMID: 36224571 (2022) — Antimalarial potential of compounds isolated from Mammea siamensis T. Anders. flowers: in vitro and molecular docking studies. · BMC complementary medicine and therapies
7.PMID: 41148731 (2025) — Thai Medicinal Flowers as Natural Antioxidants and Antibacterial Agents Against Pathogenic Enteric Bacteria: A Comparative Study of Mesua ferrea, Mammea siamensis, and Clitoria ternatea. · Antibiotics (Basel, Switzerland)
8.PMID: 23531139 (2000) — NMR study of seven coumarins from mammea siamensis. · Pharmaceutical biology
9.PMID: 36450587 (2022) — Natural Compounds with BMI1 Promoter Inhibitory Activity from Mammea siamensis and Andrographis paniculata. · Chemical & pharmaceutical bulletin
10.PMID: 37259379 (2023) — Structures of Mammeasins P and Q, Coumarin-Related Polysubstituted Benzofurans, from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Anti-Proliferative Activity of Coumarin Constituents against Human Prostate Carcinoma Cell Line LNCaP. · Pharmaceuticals (Basel, Switzerland)
11.PMID: 36232534 (2022) — Phytochemicals with Chemopreventive Activity Obtained from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Isolation and Structure Determination of New Prenylcoumarins with Inhibitory Activity against Aromatase. · International journal of molecular sciences
12.PMID: 23531138 (2000) — Chemical investigation of mammea siamensis. · Pharmaceutical biology
13.PMID: 9612959 (1998) — Xanthones from the twigs of Mammea siamensis. · Phytochemistry
14.PMID: 38601576 (2024) — Comparative discriminant analysis of Mesua ferrea L. and its adulterants. · Heliyon
15.PMID: 38521901 (2024) — In vivo antimalarial effect of 1-hydroxy-5,6,7-trimethoxyxanthone isolated from Mammea siamensis T. Anders. flowers: pharmacokinetic and acute toxicity studies. · BMC complementary medicine and therapies
16.PMID: 34953977 (2022) — Ethnopharmacological nexus between the traditional Thai medicine theory and biologically based cancer treatment. · Journal of ethnopharmacology
17.PMID: 21048341 (2010) — Cytotoxic Coumarins from the Bark of Mammea siamensis. · Chemical & pharmaceutical bulletin
18.PMID: 16563448 (2006) — Pyranocoumarins from the twigs of Mammea siamensis. · Phytochemistry
19.PMID: 24929106 (2014) — Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand. · Journal of ethnopharmacology
20.PMID: 16755064 (2006) — Siamenols A-D, four new coumarins from Mammea siamensis. · Chemical & pharmaceutical bulletin
21.PMID: 40283879 (2025) — Mammea siamensis Flower Extract-Induced Cell Death Apoptosis in HCT116 Colon Cancer Cells via Vacuolar-Type H+-ATPase Inhibition Associated with GSK-3β/β-Catenin, PI3K/Akt/NF-κB, and MAPK Signaling Pathway. · Pharmaceuticals (Basel, Switzerland)
22.PMID: 37143036 (2023) — Preclinical evaluation of antimalarial activity of CPF-1 formulation as an alternative choice for the treatment of malaria. · BMC complementary medicine and therapies
23.PMID: 33246033 (2021) — Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines. · Fitoterapia
24.PMID: 27695262 (2016) — Kayeassamin A Isolated from the Flower of Mammea siamensis Triggers Apoptosis by Activating Caspase-3/-8 in HL-60 Human Leukemia Cells. · Pharmacognosy research
25.PMID: 25518307 (2014) — In vitro cytotoxic activity of Sa-Tri-Lhung-Klod remedy and its herbal ingredients on ovarian and cervical carcinoma cell lines. · Journal of the Medical Association of Thailand = Chotmaihet thangphaet