Scutellaria Barbata (Scutellaria barbata): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Scutellaria barbata work as an anticancer herb?

Scutellaria barbata exerts potential anticancer effects primarily through its flavonoid compounds, including wogonin, baicalein, and scutellarein. Laboratory studies suggest these constituents induce apoptosis (programmed cell death) and inhibit angiogenesis, the process by which tumors form new blood vessels. The herb also demonstrates anti-inflammatory and antiproliferative properties. While traditional use focuses on clearing heat toxins, modern research investigates its ability to modulate signaling pathways involved in cancer progression. Current evidence is rated Level C, meaning results are promising but primarily derived from preclinical studies rather than large-scale human trials.

Can I take Scutellaria barbata during pregnancy?

No, Scutellaria barbata is considered unsafe during pregnancy and is strictly contraindicated. In Traditional Chinese Medicine, this herb is used to activate blood circulation and clear stagnation, actions that can stimulate uterine contractions and potentially lead to miscarriage. Due to these emmenagogue properties and a lack of safety data, pregnant women should avoid this herb entirely. Women who are breastfeeding should also exercise caution, as safety during lactation has not been established. Always consult a qualified healthcare provider before using herbal medicines during pregnancy.

What is the recommended dosage for Scutellaria barbata?

The standard adult dosage for Scutellaria barbata is 15-30 grams of the dried herb daily, typically prepared as a decoction. For concentrated extracts, a dosage of 500-1000mg per day is common. Because this herb is often combined with other botanicals in formulations, the appropriate dose can vary based on the specific condition being addressed. Individuals with a cold constitution should use this herb cautiously or avoid it. It is essential to consult a qualified practitioner to determine the correct dosage for your specific needs.

Does Scutellaria barbata interact with chemotherapy drugs?

Scutellaria barbata has the potential to interact with pharmaceutical drugs, particularly anticoagulants and antiplatelet medications, due to its blood-activating properties. Regarding chemotherapy, while some laboratory studies suggest it may enhance the efficacy of certain agents, it could also interfere with others. Patients undergoing cancer treatment should not self-prescribe this herb. It is vital to inform your oncologist about all herbal supplements, as concurrent use requires professional monitoring to avoid adverse interactions or reduced treatment efficacy.

What are the side effects of Scutellaria barbata?

Scutellaria barbata is generally well-tolerated when taken at recommended dosages. However, some individuals may experience mild gastrointestinal upset, including nausea or diarrhea. Because the herb clears heat and resolves dampness in TCM theory, it is contraindicated for individuals with a cold or weak constitution, as it may exacerbate symptoms like cold extremities, fatigue, or poor appetite. If you experience adverse reactions, discontinue use immediately and consult a healthcare professional.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Scutellaria barbata (Ban Zhi Lian) is a perennial herb used in traditional medicine for its heat-clearing, detoxifying, and anti-tumor properties [PMID:31577937, PMID:40122316].

Contexte

Scutellaria barbata D. Don is a perennial herb of the Lamiaceae family [PMID:39274982]. It is known as Ban Zhi Lian in China and Banjiryun in Korea [PMID:31577937].

Usages traditionnels

In Traditional Chinese Medicine (TCM), it is used for removing heat and toxic material, promoting blood circulation, removing blood stasis, and inducing diuresis to reduce edema [PMID:31840605, PMID:31577937].

Composés actifs

The herb contains flavonoids (including scutellarin, luteolin, baicalein, and wogonin), neoclerodane diterpenoids, polysaccharides, volatile oils, steroids, and alkaloids [PMID:31840605, PMID:33157301, PMID:21360416, PMID:41444660, PMID:42024969].

Mécanisme d'action

Mechanisms include the induction of ferroptosis via iron peroxidation and lipid ROS metabolism [PMID:35321425, PMID:42209785], activation of the Nrf2 signaling pathway [PMID:40893687], and modulation of signaling cascades such as PI3K/Akt/mTOR, MAPK, and NF-κB [PMID:39274982]. It also targets METTL5 in ovarian cancer [PMID:40425707] and inhibits the miR-6809-5p/FLOT1/FAK pathway in hepatocellular carcinoma [PMID:40857906].

Preuves cliniques

Preuve DOvarian Cancer

Scutellarin suppresses progression by targeting METTL5 [PMID:40425707]; combined with Hedyotis diffusa and cisplatin, it synergistically inhibits progression via NRF2-FTH1 autophagic degradation [PMID:39702302]; and induces ferroptosis in A2780 cells [PMID:39521705].

Preuve DHepatocellular Carcinoma (HCC)

Induces ferroptosis of HCC cells [PMID:35321425]; exosome-like nanovesicles promote ferroptosis through the Nrf2/SLC7A11/GPX4 pathway [PMID:42209785]; and luteolin inhibits invasion via the miR-6809-5p/FLOT1/FAK pathway [PMID:40857906].

Preuve DBreast Cancer

Water extract suppresses growth and lung metastasis by inducing ferroptosis and inhibiting epithelial-mesenchymal transition (EMT) [PMID:42244109]; combined with Hedyotis diffusa, it inhibits proliferation via targeting LMO1 and AKT/Mtor signaling [PMID:37711008].

Preuve DAcute Kidney Injury (AKI)

Self-assembled herbal nanoparticles (with Scleromitrion diffusum) mitigate AKI progression by activating the Nrf2 signaling pathway in mice [PMID:40893687].

Preuve DAcute Respiratory Distress Syndrome (ARDS)

Ethanol extract may ameliorate ARDS by inhibiting neutrophil-mediated inflammatory responses [PMID:40122316].

Interactions médicamenteuses

Synergistic effects have been noted when combined with cisplatin to enhance chemosensitivity in ovarian cancer [PMID:39702302].

Synthèse des preuves

The current evidence is primarily based on in vitro cell lines and in vivo animal models (Level D), focusing heavily on anti-tumor mechanisms and inflammatory responses; clinical trial data is lacking.

Sources PubMed

1.PMID: 40893687 (2025) — Unveiling the renoprotective mechanisms of self-assembled herbal nanoparticles from Scutellaria barbata and Scleromitrion diffusum in acute kidney injury: A nano-TCM approach. · Acta pharmaceutica Sinica. B
2.PMID: 40122316 (2025) — Scutellaria barbata ameliorates acute respiratory distress syndrome by inhibiting neutrophil-mediated inflammatory responses. · Journal of ethnopharmacology
3.PMID: 40425707 (2025) — Scutellarin suppresses ovarian cancer progression by targeting METTL5. · Scientific reports
4.PMID: 39702302 (2024) — Scutellaria barbata D.Don and Hedyotis diffusa Willd herb pair combined with cisplatin synergistically inhibits ovarian cancer progression through modulating oxidative stress via NRF2-FTH1 autophagic degradation pathway. · Journal of ovarian research
5.PMID: 31840605 (2020)

Scutellaria Barbata

Sources et citations

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