Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Contexte
Usages traditionnels
Composés actifs
Mécanisme d'action
Preuves cliniques
Ethanolic root extract induced apoptosis in A549 lung cancer cells [PMID: 20953431, 20869020] and showed anticancer potential against benzo[a]pyrene-induced lung cancer in mice [PMID: 21419086].
Senegin-II and senegasaponins significantly reduced blood glucose levels in normal and non-insulin dependent diabetic (KK-Ay) mice [PMID: 8923811, 9214731, 8535417, 8582013, 8706138].
Extract fractions significantly inhibited LPS-induced inflammatory cytokines IL-1beta, IL-6, and TNFalpha in murine macrophage RAW 164.7 cells [PMID: 19577624].
Saponins from the root acted as adjuvants, increasing specific antibody responses and IL-2 levels in mice [PMID: 18066120, 10660256].
Senegasaponins and senegins exhibited inhibitory effects on ethanol absorption in rats [PMID: 7728939, 8582013, 8706138].
Sécurité et effets indésirables
Synthèse des preuves
Sources PubMed
- 1.PMID: 20953431 (2011) — Anticancer Potentials of Root Extract of Polygala senega and Its PLGA Nanoparticles-Encapsulated Form. · Evidence-based complementary and alternative medicine : eCAM
- 2.PMID: 34730980 (2021) — Preparation of Tenuifolin from Polygala senega L. Root Using a Hydrolytic Continuous Flow System under High-Temperature, High-Pressure Conditions. · The Journal of organic chemistry
- 3.PMID: 18066120 (2007) — Adjuvant activities of saponins from the root of Polygala senega L. · Canadian journal of physiology and pharmacology
- 4.PMID: 21419086 (2011) — Anticancer potentials of root extract of Polygala senega against benzo[a]pyrene-induced lung cancer in mice. · Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
- 5.PMID: 20869020