Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
PubMed · Sesame (<i>Sesamum indicum</i> L.): A Comprehensive Review of Nutritional Value, Phytochemical Composition, Health Benefits, Development of Food, and Industrial Applications. (2022)
PubMed · QTL mapping in sesame (Sesamum indicum L.): A review. (2023)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Dernière mise à jour : April 2026
Calculer une dose sûre de Herbe de sésame
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Sesame seeds contain bioactive lignans, primarily sesamin and sesamol, which function as potent antioxidants. These compounds help neutralize free radicals, reducing oxidative stress throughout the body (Evidence Level C). Mechanistically, sesamin has been shown to influence liver enzyme activity, specifically inhibiting fatty acid synthesis while promoting fatty acid oxidation. Additionally, the high tocopherol (vitamin E) content supports skin barrier function and provides systemic anti-inflammatory effects, contributing to its traditional use as a nutritive liver tonic.
Does sesame interact with blood thinners or other medications?
There are currently no well-documented severe drug interactions for sesame at culinary doses (Evidence Level D). However, because sesame oil contains vitamin K and may affect platelet aggregation, patients taking anticoagulants like warfarin should monitor their intake to maintain consistent vitamin K levels. Theoretical interactions exist regarding liver enzyme modulation, but clinical significance remains low. Always consult a healthcare provider before adding high doses of sesame to a regulated medication regimen.
What is the recommended daily dosage for sesame seeds?
The standard adult dosage for therapeutic benefits is 2 to 3 tablespoons of seeds or oil daily (Traditional use). To maximize nutrient absorption, the seeds should be ground or chewed thoroughly, as the hull can reduce bioavailability. This quantity provides adequate sesamin and tocopherols to support liver health and skin integrity. Consistent daily intake is recommended for best results, but users should stay within this range to avoid gastrointestinal discomfort.
Is sesame safe to consume during pregnancy?
Sesame is generally considered safe for consumption during pregnancy when eaten in normal food amounts (Evidence Level C/Traditional). It provides essential nutrients like calcium, iron, and fatty acids that support fetal development. However, pregnant women should avoid consuming large, medicinal quantities. The primary safety concern is an existing sesame allergy, which can trigger severe reactions. Women with a history of seed allergies should exercise caution and consult their doctor.
Can sesame seeds help with liver health?
Yes, sesame has a long history of use as a liver tonic in Ayurvedic medicine (Traditional). Modern research suggests that sesamin, a primary lignan in sesame, may support liver function by enhancing fatty acid oxidation and reducing lipid accumulation in the liver (Evidence Level C). While human clinical trials are limited, animal studies indicate protective effects against liver damage. It is best used as a supportive food medicine rather than a primary treatment for liver disease.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Sesame (Sesamum indicum L.) is an ancient oilseed crop rich in proteins, lipids, and lignans, offering various health benefits including antioxidant and cholesterol-reducing effects [PMID:36235731, PMID:38672826].
Contexte
Sesame (Sesamum indicum L.) is a member of the Pedaliaceae family and is one of the first oil crops used by humans [PMID:36235731]. It is grown globally in tropical and subtropical regions, including Africa, Asia, and the Americas [PMID:25416247, PMID:35106386].
Usages traditionnels
Sesame is used as a medicinal and edible homologous food in various aspects of daily life, including food, feed, and cosmetics [PMID:36235731]. Historically, in the southern United States, it was used in African-American cuisine for dishes such as benne soup, benne and greens, benne and hominy, benne candy, and benne wafers [PMID:21568041].
Composés actifs
Sesame seeds contain lignan-like active ingredients, specifically sesamin, sesamolin, sesamol, and sesaminol [PMID:36235731, PMID:33562414, PMID:31817084]. Other phytochemicals include tocopherol isomers, phytosterols, and phytates [PMID:38672826].
Mécanisme d'action
Sesame and its lignans (sesamin and sesamolin) regulate atherosclerosis by decreasing lipid peroxidation and modulating inflammatory cytokines and signaling pathways, including prostaglandin E2 (PGE2), nuclear factor kappa light-chain enhancer of activated B cells (NF-kB), and peroxisome proliferator-activated receptor gamma (PPAR-gamma) [PMID:37457142]. Sesamol acts as a metabolic regulator with radical scavenging ability and the capacity to regulate apoptosis and the cell cycle [PMID:31063773].
Sesame seeds and their compounds are effective in cholesterol management and blood lipid regulation [PMID:36235731, PMID:38672826, PMID:21842753]
Preuve CCancer
Sesamol exhibits potent anti-cancer effects and chemopreventive properties in various cell lines and animal models [PMID:31063773]
Sécurité et effets indésirables
Aqueous extracts of sesame have been shown to be safe for animals [PMID:36235731]. However, sesame is considered an allergenic food that can trigger mild to severe adverse reactions, including anaphylaxis [PMID:38531299].
Synthèse des preuves
The evidence for glycemic control in type 2 diabetes is strong (meta-analysis). Other health benefits, such as anti-inflammatory, anti-cancer, and lipid-lowering effects, are primarily supported by reviews of in vitro and in vivo studies.
Sources PubMed
1.PMID: 36235731 (2022) — Sesame (Sesamum indicum L.): A Comprehensive Review of Nutritional Value, Phytochemical Composition, Health Benefits, Development of Food, and Industrial Applications. · Nutrients
4.PMID: 33562414 (2021) — Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review. · Molecules (Basel, Switzerland)
5.PMID: 21842753 (2011) — [Nutritional value of sesame seeds]. · Voprosy pitaniia
6.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
PMID: 21568041 (2010) — Prospecting for oil. · Gastronomica : the journal of food and culture
7.PMID: 35106386 (2022) — Genome-wide analysis of codon usage in sesame (Sesamum indicum L.). · Heliyon
8.PMID: 38531299 (2024) — Recent advance in sesame allergens: Influence of food processing and their detection methods. · Food chemistry
9.PMID: 37317803 (2023) — Effect of sesame (Sesamum indicum L.) consumption on glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. · Phytotherapy research : PTR
10.PMID: 31063773 (2019) — Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action. · European journal of pharmacology
11.PMID: 37457142 (2023) — Effects of sesame (Sesamum indicum L.) and bioactive compounds (sesamin and sesamolin) on inflammation and atherosclerosis: A review. · Food science & nutrition
12.PMID: 31817084 (2019) — Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.-A Review. · Molecules (Basel, Switzerland)