Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Shirish (Albizia lebbeck) contains saponins and flavonoids that exhibit antihistamine and anti-inflammatory properties. These active compounds are believed to stabilize mast cells, preventing the release of histamine and other inflammatory mediators responsible for allergic reactions. Traditional Ayurvedic use and preliminary research (Evidence Level C) suggest it modulates immune response, reducing hypersensitivity reactions in the respiratory tract and skin. The herb's immunomodulatory effects may help desensitize the body to allergens over time.
Does Shirish interact with any medications?
Shirish may interact with immunosuppressant medications due to its immunomodulatory properties, potentially reducing their effectiveness. It may also enhance the sedative effects of central nervous system depressants, including antihistamines, benzodiazepines, and sleep medications, causing increased drowsiness. Limited clinical data exists on specific drug interactions (Evidence Level C). Individuals taking anticoagulants should exercise caution, as Shirish contains compounds that may affect blood clotting. Always consult a qualified healthcare provider before combining Shirish with prescription medications.
What is the recommended dosage of Shirish?
The typical adult dosage of Shirish is 2-4 grams of bark powder daily, or 500mg of standardized extract taken twice daily. For acute allergic conditions, practitioners may recommend the higher end of this range. Traditional Ayurvedic preparations often use decoctions made from the bark. Standardized extracts should contain consistent levels of active saponins. Dosage should be adjusted based on individual response and under guidance from a qualified herbalist or healthcare provider. Evidence for optimal dosing remains limited (Evidence Level C).
Is Shirish safe during pregnancy and breastfeeding?
Shirish is considered unsafe during pregnancy and should be strictly avoided. Traditional Ayurvedic texts and modern safety assessments contraindicate its use in pregnant women due to potential uterine-stimulating effects and insufficient safety data. Breastfeeding women should also avoid Shirish, as there is inadequate research on whether its active compounds pass into breast milk or affect infant development. Women who are pregnant, planning pregnancy, or breastfeeding should consult their healthcare provider for safer alternatives to manage allergies or skin conditions.
What are the main benefits of Shirish for respiratory health?
Shirish is traditionally used in Ayurveda to support respiratory health, particularly for allergic rhinitis, asthma, and bronchitis. Its anti-allergic and anti-inflammatory properties may help reduce airway inflammation, decrease mucus production, and ease breathing difficulties. Preliminary research (Evidence Level C) suggests potential benefits for reducing the frequency and severity of asthma attacks and allergic respiratory symptoms. The herb's mast cell-stabilizing action may help prevent allergic cascades in the respiratory tract. However, more rigorous clinical studies are needed to confirm these traditional uses.
What side effects can Shirish cause?
Shirish is generally well-tolerated at recommended doses, but some individuals may experience mild digestive disturbances including nausea, bloating, or stomach discomfort. Drowsiness has been reported in some users, particularly when taken in higher doses or combined with other sedating substances. Individuals with autoimmune conditions should avoid Shirish due to its immune-modulating properties, which could potentially exacerbate these conditions. Allergic reactions to the herb itself are rare but possible. Discontinue use if adverse effects occur and consult a healthcare provider.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Albizia lebbeck, known as Sirisha in Sanskrit, is a deciduous tree native to tropical Asia, Africa, and Northern Australia with diverse pharmacological potentials [PMID:30408535, PMID:37707729, PMID:35497931].
Contexte
Albizia lebbeck (L.) Benth. is a woody legume of the Fabaceae (Mimosoideae) family [PMID:35105225, PMID:37707729].
Usages traditionnels
It is used in Nigeria, South Africa, and other countries to treat flu, fever, pain, epilepsy, and inflammation [PMID:33301915]. Traditional medicine claims the use of leaves and pods against cancer [PMID:30408535]. It is also reported for use in respiratory, skin, gastrointestinal, oral, eye, urinary, genital, anorectal, inflammatory, neurological, and venereal disorders [PMID:35497931].
Composés actifs
Identified compounds include saponins (albiziasaponins A-E, echinocystic acid saponins) [PMID:7766399, PMID:30408535, PMID:35105225], flavonoids (kaempferol, quercetin, luteolin) [PMID:9664705, PMID:38565590], polyphenols (catechin) [PMID:20109037], and volatile oil components such as 2-pentylfuran and (E)-geranyl acetone [PMID:33301915]. Other identified constituents include thunbergol, lupenone, and squalene [PMID:40974554].
Mécanisme d'action
Leaf extracts may exert neuroprotective effects by inhibiting ER stress proteins (calpain1 and caspase-12) and suppressing apoptotic proteins (Bax, cytochrome c, cleaved caspase-9, and cleaved caspase-3) [PMID:37513900]. Luteolin, a major constituent, may attenuate glutamate-induced autophagy-mediated cell death via activation of mTORC1 and inactivation of BNIP3L/NIX [PMID:38565590]. Other mechanisms include modulation of the NF-κB signaling pathway [PMID:40974554] and mast cell stabilization via modulation of histamine release and cytokine expression [PMID:20109037].
Preuves cliniques
Preuve DNeurodegenerative/Pain
Leaf extracts showed neuroprotective potential against cisplatin-induced neuropathic pain in mice [PMID:40974554].
Preuve DCancer
Saponin-rich fractions and methanolic extracts demonstrated antiproliferative and anti-migratory activity against MCF-7 and MDA-MB 231 breast cancer cells in vitro [PMID:30408535, PMID:37375805]. Ethanolic pod extract showed antitumor activity against Ehrlich ascites carcinoma in vivo [PMID:34121697].
Preuve DInflammation/Pain
Volatile oils exhibited anti-nociceptive and anti-inflammatory properties in pain models [PMID:33301915].
Methanolic seed extracts showed antioxidant, anti-diabetic (alpha-amylase inhibition), and anti-lipidemic potential in HepG2 cells [PMID:35791478].
Preuve DHepatoprotection
Synthèse des preuves
The current evidence consists primarily of in vitro studies and animal models (Level D), demonstrating potential antioxidant, anti-inflammatory, neuroprotective, and antitumor activities. There are no human clinical trials (Level B) or systematic reviews of clinical data (Level A) provided in the source abstracts.
Sources PubMed
1.PMID: 7766399 (1995) — Saponins from Albizia lebbeck. · Phytochemistry
2.PMID: 34021684 (2022) — Development and cosmeceutical evaluation of topical emulgel containing Albizia lebbeck bark extract. · Journal of cosmetic dermatology
3.PMID: 33301915 (2021) — Albizia lebbeck and Albizia zygia volatile oils exhibit anti-nociceptive and anti-inflammatory properties in pain models. · Journal of ethnopharmacology
5.PMID: 30408535 (2019) — Anticancer activity of saponin isolated from Albizia lebbeck using various in vitro models. · Journal of ethnopharmacology
6.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Flower extracts showed promising activity in reducing AST, ALT, and bilirubin levels in vivo [PMID:28223871].
PMID: 35105225 (2023) — Two new triterpenoid saponins from the flowers of Albizia lebbeck. · Natural product research
7.PMID: 39140636 (2024) — Methylene blue and Congo red dye elimination from synthetic wastewater using Albizia lebbeck seed pod powder: isotherm and kinetic and mechanistic studies. · International journal of phytoremediation
8.PMID: 35497931 (2022) — A Comprehensive Insight into the Phytochemical, Pharmacological Potential, and Traditional Medicinal Uses of Albizia lebbeck (L.) Benth. · Evidence-based complementary and alternative medicine : eCAM
9.PMID: 37513900 (2023) — Neuroprotective Effects of Albizia lebbeck (L.) Benth. Leaf Extract against Glutamate-Induced Endoplasmic Reticulum Stress and Apoptosis in Human Microglial Cells. · Pharmaceuticals (Basel, Switzerland)
10.PMID: 37707729 (2024) — Yield model and yield table construction in Albizia (Albizia lebbeck (L.) under the western agro-climatic zone of Tamil Nadu, Southern India. · Environmental science and pollution research international
11.PMID: 28816555 (2018) — Chemical Utilization of Albizia lebbeck Leaves for Developing Protein Concentrates as a Dietary Supplement. · Journal of dietary supplements
12.PMID: 35930104 (2022) — Effects of using siris (Albizia lebbeck) foliage in the diet of fattening lambs on nutrient digestibility, blood and rumen parameters, growth performance, and meat quality characteristics. · Tropical animal health and production
13.PMID: 39067721 (2024) — A novel edible coating based on Albizia [Albizia lebbeck (L.) Benth.] gum delays softening and maintains quality of harvested guava fruits during storage. · International journal of biological macromolecules
14.PMID: 31805998 (2019) — Systems pharmacology based approach to investigate the in-vivo therapeutic efficacy of Albizia lebbeck (L.) in experimental model of Parkinson's disease. · BMC complementary and alternative medicine
15.PMID: 42303927 (2026) — Bioactivity profiling of endophytic fungi isolated from Albizia lebbeck: Antimicrobial, antioxidant, and cytotoxic evaluations. · Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
16.PMID: 35956773 (2022) — Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae). · Molecules (Basel, Switzerland)
17.PMID: 20109037 (2010) — Anti-allergic activity of standardized extract of Albizia lebbeck with reference to catechin as a phytomarker. · Immunopharmacology and immunotoxicology
18.PMID: 34121697 (2021) — Antitumor activity of Albizia lebbeck L. against Ehrlich ascites carcinoma in vivo and HeLa and A549 cell lines in vitro. · Journal of cancer research and therapeutics
19.PMID: 28223871 (2017) — New acyclic secondary metabolites from the biologically active fraction of Albizia lebbeck flowers. · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
20.PMID: 35791478 (2022) — Anti-diabetic and anti-lipidepmic effect of Albizia lebbeck seeds against HepG2 cells. · Pakistan journal of pharmaceutical sciences
21.PMID: 29573314 (2018) — New cytochalasin from Rosellinia sanctae-cruciana, an endophytic fungus of Albizia lebbeck. · Journal of applied microbiology
22.PMID: 37593463 (2023) — Identification of phytoconstituents from Albizia lebbeck as potential therapeutics against HIV-1 reverse transcriptase associated with infective endocarditis: In silico and in vitro approaches. · Saudi journal of biological sciences
23.PMID: 40453119 (2025) — A review of the developments in adsorbents for the efficient adsorption of ibuprofen from wastewater. · RSC advances
24.PMID: 40974554 (2025) — Neuroprotective Role of Albizia lebbeck Leaves Against Cisplatin-Induced Neuropathic Pain via Modulating NF-κB Signalling Pathway. · Chemistry & biodiversity
25.PMID: 33628155 (2021) — Antibacterial Activity of Tris NaCl and PBS Buffer Protein Extract of Cassia fistula, Saccharum officinarum, Albizia lebbeck and Cymbopogon citrates Against Bacterial Strains. · Dose-response : a publication of International Hormesis Society
26.PMID: 38565590 (2024) — Neuroprotective mechanisms of luteolin in glutamate-induced oxidative stress and autophagy-mediated neuronal cell death. · Scientific reports
27.PMID: 31762624 (2019) — Pollination biology of Albizia lebbeck (L.) Benth. (Fabaceae: Mimosoideae) with reference to insect floral visitors. · Saudi journal of biological sciences
28.PMID: 37375805 (2023) — Prediction of Cell Migration in MDA-MB 231 and MCF-7 Human Breast Cancer Cells Treated with Albizia Lebbeck Methanolic Extract Using Multilinear Regression and Artificial Intelligence-Based Models. · Pharmaceuticals (Basel, Switzerland)