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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Simarouba glauca
Tropical American Simaroubaceae; seeds yield edible oil; bark used for malaria and GI conditions in folk medicine.
Simarouba glauca, a tropical tree of the Simaroubaceae family, is traditionally used for malaria, amoebiasis, and dysentery, with modern research supporting anti-malarial, anti-amoebic, and anti-diabetic activities. Its bark contains quassinoids such as glaucarubine and simarolide, along with flavonoids and fatty acids, which contribute to its therapeutic effects. The plant is also a source of edible seed oil and has been investigated as a biofuel.
Quassinoids, particularly glaucarubine, inhibit protein synthesis in Plasmodium falciparum by binding to the 80S ribosome, leading to parasite death. Anti-amoebic activity involves disruption of Entamoeba histolytica trophozoite membranes and inhibition of glycolysis. Anti-diabetic effects are mediated through activation of AMP-activated protein kinase (AMPK) and enhancement of insulin sensitivity in peripheral tissues. Additionally, simarolide exhibits anti-inflammatory activity by suppressing NF-κB and COX-2 pathways.
Tropical American Simaroubaceae; seeds yield edible oil; bark used for malaria and GI conditions in folk medicine.
Simarouba glauca, a tropical tree of the Simaroubaceae family, is traditionally used for malaria, amoebiasis, and dysentery, with modern research supporting anti-malarial, anti-amoebic, and anti-diabetic activities. Its bark contains quassinoids such as glaucarubine and simarolide, along with flavonoids and fatty acids, which contribute to its therapeutic effects. The plant is also a source of edible seed oil and has been investigated as a biofuel.
Quassinoids, particularly glaucarubine, inhibit protein synthesis in Plasmodium falciparum by binding to the 80S ribosome, leading to parasite death. Anti-amoebic activity involves disruption of Entamoeba histolytica trophozoite membranes and inhibition of glycolysis. Anti-diabetic effects are mediated through activation of AMP-activated protein kinase (AMPK) and enhancement of insulin sensitivity in peripheral tissues. Additionally, simarolide exhibits anti-inflammatory activity by suppressing NF-κB and COX-2 pathways.