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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Saussurea costus
Sacred Tibetan medicinal herb used in Sowa Rigpa for respiratory diseases, digestive disorders, and as a tonic. Grows at high altitudes.
Snow Lotus (Saussurea costus) is a sacred Tibetan herb used in Sowa Rigpa for respiratory and digestive disorders, valued for its anti-inflammatory, bronchodilator, and hepatoprotective properties. Its primary active compounds include costunolide, dehydrocostus lactone, and cynaropicrin, which are sesquiterpene lactones responsible for its pharmacological effects. Despite traditional use, clinical evidence is limited (Level C), and caution is warranted due to potential hepatotoxicity at high doses.
Costunolide and dehydrocostus lactone inhibit NF-κB and COX-2 pathways, reducing pro-inflammatory cytokines (TNF-α, IL-6) and prostaglandin synthesis. These compounds also act as bronchodilators by relaxing tracheal smooth muscle via calcium channel blockade and β2-adrenergic receptor agonism. Cynaropicrin exhibits hepatoprotective effects by upregulating antioxidant enzymes (SOD, GPx) and reducing oxidative stress, though high doses may induce liver stress through reactive metabolite formation. Additionally, sesquiterpene lactones stimulate digestive secretions and modulate gut motility via 5-HT3 receptor antagonism.
Sacred Tibetan medicinal herb used in Sowa Rigpa for respiratory diseases, digestive disorders, and as a tonic. Grows at high altitudes.
Snow Lotus (Saussurea costus) is a sacred Tibetan herb used in Sowa Rigpa for respiratory and digestive disorders, valued for its anti-inflammatory, bronchodilator, and hepatoprotective properties. Its primary active compounds include costunolide, dehydrocostus lactone, and cynaropicrin, which are sesquiterpene lactones responsible for its pharmacological effects. Despite traditional use, clinical evidence is limited (Level C), and caution is warranted due to potential hepatotoxicity at high doses.
Costunolide and dehydrocostus lactone inhibit NF-κB and COX-2 pathways, reducing pro-inflammatory cytokines (TNF-α, IL-6) and prostaglandin synthesis. These compounds also act as bronchodilators by relaxing tracheal smooth muscle via calcium channel blockade and β2-adrenergic receptor agonism. Cynaropicrin exhibits hepatoprotective effects by upregulating antioxidant enzymes (SOD, GPx) and reducing oxidative stress, though high doses may induce liver stress through reactive metabolite formation. Additionally, sesquiterpene lactones stimulate digestive secretions and modulate gut motility via 5-HT3 receptor antagonism.