How does Solanum xanthocarpum work for cough and asthma?

Solanum xanthocarpum contains bioactive compounds including solasonine, solamargine, and diosgenin that exhibit bronchodilatory and anti-inflammatory properties. These alkaloids and flavonoids help relax bronchial smooth muscles and reduce airway inflammation. The herb also demonstrates expectorant activity, helping to clear mucus from respiratory passages. As one of the Dashamoola roots in Ayurveda, it has traditional use for respiratory conditions (Evidence Level: C, Traditional).

Does Solanum xanthocarpum interact with any medications?

Solanum xanthocarpum may interact with antidiabetic medications due to potential effects on blood glucose levels. Limited data exists on specific drug interactions. The herb contains steroidal alkaloids that could theoretically affect liver enzyme metabolism of certain drugs. Patients taking bronchodilators or corticosteroids for asthma should use caution, as additive effects are unknown. Always consult a healthcare provider before combining this herb with prescription medications (Evidence Level: D).

What is the recommended dosage of Solanum xanthocarpum?

The typical adult dosage of Solanum xanthocarpum is 3-5 grams of dried plant prepared as a decoction, taken twice daily. Alternatively, 1-2 grams of powdered herb may be used. Traditional Ayurvedic preparations often combine it with other Dashamoola roots. Dosage should be adjusted based on individual tolerance and under guidance from a qualified practitioner. Start with lower doses to assess tolerance (Evidence Level: Traditional).

Is Solanum xanthocarpum safe during pregnancy?

Solanum xanthocarpum is considered unsafe during pregnancy and should be avoided. The herb contains steroidal alkaloids, including solasonine and solamargine, which may have uterine stimulant effects and potential teratogenic properties. Traditional Ayurvedic texts contraindicate its use in pregnancy. Women who are pregnant, planning pregnancy, or breastfeeding should not use this herb. Those with nightshade sensitivity should also avoid it due to potential allergic reactions (Evidence Level: C, Traditional).

What is Solanum xanthocarpum used for in Ayurveda?

Solanum xanthocarpum is one of the ten roots in Dashamoola, an important Ayurvedic formulation. It is traditionally used for cough, asthma, bronchitis, and fever. The herb also addresses urinary conditions and acts as a diuretic. Known as Kantakari in Ayurveda, it is valued for its respiratory and anti-inflammatory properties. Current evidence supporting these traditional uses remains limited (Evidence Level: C, Traditional).

Solanum xanthocarpum (Solanum virginianum)

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Solanum xanthocarpum (also known as Solanum virginianum or Kantakari) is a medicinal herb used in Ayurveda and Siddha medicine, primarily for respiratory conditions and inflammation [PMID:24991071, PMID:10433479].

Contexte

Solanum xanthocarpum (S. virginianum) is a diffuse herb characterized by a prickly stem [PMID:24991071]. It is a component of the traditional Ayurvedic herbal formulation 'Dashamula' (ten roots) and 'Laghupanchamula' [PMID:40637800, PMID:23723639].

Usages traditionnels

Traditionally used in Ayurveda and Siddha systems for the treatment of inflammation [PMID:24991071], bronchial asthma, cough (Kasa), and hiccups (Hikka) [PMID:38075186]. It is also used as an antipyretic and for skin infections [PMID:28052238, PMID:38825191].

Composés actifs

The plant contains the steroidal alkaloid solasodine [PMID:41330956, PMID:32388600], as well as demissidine [PMID:38825191]. Fruit extracts have yielded various terpenoids (e.g., actini-dioionoside A, citroside A) [PMID:37748096] and new compounds such as virginianoside A, a steroidal alkaloid saponin [PMID:41005497].

Mécanisme d'action

In neuropathic pain models, the extract restored antioxidant levels and inhibited pro-inflammatory cytokines IL-1β and TNF-α [PMID:32388600]. Certain compounds from the fruit exhibit anti-inflammatory activity in LPS-induced RAW 264.7 models [PMID:39015011]. It has also been shown to enhance the bioavailability of Isoniazid (INH) by compromising the cell wall integrity of Mycobacterium smegmatis [PMID:39081888].

Preuves cliniques

Preuve BBronchial Asthma

A single dose of 300 mg whole plant powder significantly improved pulmonary function parameters (FVC, FEV1, PEFR, FEF25-75%), though the effect was less than standard bronchodilators [PMID:10433479].

Preuve BBronchial Asthma

Kantakari Avaleha and its granule form were evaluated for efficacy in patients with mild to moderate bronchial asthma [PMID:38075186].

Sécurité et effets indésirables

In a pilot clinical study, no untoward effects were reported following the administration of 300 mg of whole plant powder [PMID:10433479].

Interactions médicamenteuses

Solanum virginianum extract was found to augment the susceptibility of Mycobacterium smegmatis to Isoniazid (INH) by enhancing its bioavailability [PMID:39081888].

Synthèse des preuves

Evidence is primarily based on animal models (D) and in vitro studies (D), with limited clinical trial data (B) focusing on respiratory health. Most findings support traditional uses for asthma and inflammation, though efficacy varies by compound and delivery method.

Sources PubMed

1.PMID: 24991071 (2013) — Evaluation of anti-inflammatory activity of Solanum xanthocarpum Schrad and Wendl (Kaṇṭakāri) extract in laboratory animals. · Ancient science of life
2.PMID: 37748096 (2023) — Terpenoid compounds from the fruits of Solanum virginianum. · Zeitschrift fur Naturforschung. C, Journal of biosciences
3.PMID: 41330956 (2025) — Exploring phenotypic stability for berry yield of Solasodine rich germplasm accessions of Kantakari (Solanum virginianum L.), using AMMI stability model. · Scientific reports
4.PMID: 38031596 (2023) — Biogenic synthesis of AuNPs using Solanum virginianum L. and their antibacterial, antioxidant and catalytic applications. · Indian journal of microbiology
5.PMID: 38075186

Solanum xanthocarpum

Sources et citations

Glaucium flavum

Glycyrrhiza aspera

Tussilago japonica

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Interactions médicamenteuses

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Solanum xanthocarpum

Sources et citations

Plantes associées

Glaucium flavum

Glycyrrhiza aspera

Tussilago japonica

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Interactions médicamenteuses

Synthèse des preuves

Sources PubMed

Sources gouvernementales