Fiche d'information compilée à partir de PubMed
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Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Solanum xanthocarpum (also known as Solanum virginianum or Kantakari) is a medicinal herb used in Ayurveda and Siddha medicine, primarily for respiratory conditions and inflammation [PMID:24991071, PMID:10433479].
Contexte
Solanum xanthocarpum (S. virginianum) is a diffuse herb characterized by a prickly stem [PMID:24991071]. It is a component of the traditional Ayurvedic herbal formulation 'Dashamula' (ten roots) and 'Laghupanchamula' [PMID:40637800, PMID:23723639].
Usages traditionnels
Traditionally used in Ayurveda and Siddha systems for the treatment of inflammation [PMID:24991071], bronchial asthma, cough (Kasa), and hiccups (Hikka) [PMID:38075186]. It is also used as an antipyretic and for skin infections [PMID:28052238, PMID:38825191].
Composés actifs
The plant contains the steroidal alkaloid solasodine [PMID:41330956, PMID:32388600], as well as demissidine [PMID:38825191]. Fruit extracts have yielded various terpenoids (e.g., actini-dioionoside A, citroside A) [PMID:37748096] and new compounds such as virginianoside A, a steroidal alkaloid saponin [PMID:41005497].
Mécanisme d'action
In neuropathic pain models, the extract restored antioxidant levels and inhibited pro-inflammatory cytokines IL-1β and TNF-α [PMID:32388600]. Certain compounds from the fruit exhibit anti-inflammatory activity in LPS-induced RAW 264.7 models [PMID:39015011]. It has also been shown to enhance the bioavailability of Isoniazid (INH) by compromising the cell wall integrity of Mycobacterium smegmatis [PMID:39081888].
Preuves cliniques
Preuve BBronchial Asthma
A single dose of 300 mg whole plant powder significantly improved pulmonary function parameters (FVC, FEV1, PEFR, FEF25-75%), though the effect was less than standard bronchodilators [PMID:10433479].
Preuve BBronchial Asthma
Kantakari Avaleha and its granule form were evaluated for efficacy in patients with mild to moderate bronchial asthma [PMID:38075186].
Sécurité et effets indésirables
In a pilot clinical study, no untoward effects were reported following the administration of 300 mg of whole plant powder [PMID:10433479].
Interactions médicamenteuses
Solanum virginianum extract was found to augment the susceptibility of Mycobacterium smegmatis to Isoniazid (INH) by enhancing its bioavailability [PMID:39081888].
Synthèse des preuves
Evidence is primarily based on animal models (D) and in vitro studies (D), with limited clinical trial data (B) focusing on respiratory health. Most findings support traditional uses for asthma and inflammation, though efficacy varies by compound and delivery method.
Sources PubMed
- 1.PMID: 24991071 (2013) — Evaluation of anti-inflammatory activity of Solanum xanthocarpum Schrad and Wendl (Kaṇṭakāri) extract in laboratory animals. · Ancient science of life
- 2.PMID: 37748096 (2023) — Terpenoid compounds from the fruits of Solanum virginianum. · Zeitschrift fur Naturforschung. C, Journal of biosciences
- 3.PMID: 41330956 (2025) — Exploring phenotypic stability for berry yield of Solasodine rich germplasm accessions of Kantakari (Solanum virginianum L.), using AMMI stability model. · Scientific reports
- 4.PMID: 38031596 (2023) — Biogenic synthesis of AuNPs using Solanum virginianum L. and their antibacterial, antioxidant and catalytic applications. · Indian journal of microbiology
- 5.PMID: 38075186 (2022) — Efficacy of Kantakari Avaleha and its modified dosage form of Kantakari Avaleha granules in the management of bronchial asthma - An open-label randomized controlled clinical trial.