Sonneratia caseolaris (Sonneratia caseolaris): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Sonneratia caseolaris work to reduce fever?

Sonneratia caseolaris contains flavonoids, tannins, and phenolic acids that contribute to its antipyretic and antimicrobial properties. These compounds are believed to work by inhibiting inflammatory mediators and providing antioxidant activity that helps reduce oxidative stress associated with fever and infection. The plant's bioactive constituents may also support skin healing through antimicrobial action when applied topically. Evidence level: C (preliminary research).

Does Sonneratia caseolaris interact with any medications?

There is limited clinical data on drug interactions for Sonneratia caseolaris. Due to its tannin content, it may potentially interfere with the absorption of certain medications when taken concurrently. Additionally, its antimicrobial and antipyretic properties could theoretically interact with antibiotic or antipyretic drugs. Patients taking prescription medications should consult a healthcare provider before using this herb. Evidence level: C.

What is the recommended dosage for Sonneratia caseolaris?

The traditional adult dosage for Sonneratia caseolaris is 2-3 grams of dried fruit prepared as a tea, taken once or twice daily. This preparation is commonly used for fever management in Southeast Asian folk medicine. There is no standardized clinical dosage established from clinical trials, so users should follow traditional guidelines and consult a qualified herbalist or healthcare provider for personalized recommendations. Evidence level: Traditional.

Is Sonneratia caseolaris safe during pregnancy?

Sonneratia caseolaris is considered unsafe during pregnancy and should be avoided. The herb has traditional contraindications for pregnant women, though specific teratogenic data is limited. Due to insufficient safety evidence and potential effects on uterine function, pregnant and breastfeeding women should not use this herb. Women of childbearing age should use appropriate contraception if using this herb medicinally. Evidence level: C.

What are the traditional uses of Sonneratia caseolaris fruit?

Sonneratia caseolaris fruit has been used traditionally in Southeast Asian folk medicine primarily for treating fevers and various skin conditions. The fruit is often prepared as a poultice for external application to wounds, skin infections, and inflammatory skin conditions. Internally, the dried fruit is brewed as a tea for its antipyretic properties. These uses are based on ethnobotanical tradition rather than extensive clinical trials. Evidence level: Traditional.

What are the side effects of Sonneratia caseolaris?

Sonneratia caseolaris may cause mild reactions in some individuals, including gastrointestinal discomfort or allergic skin responses. Those with known allergies to mangrove species or related plants should exercise caution. Due to limited safety data, users should start with lower doses and discontinue use if adverse reactions occur. Seek medical attention if severe symptoms develop. Evidence level: C.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Sonneratia caseolaris, also known as the mangrove apple, is a mangrove species recognized for its antioxidant and antimicrobial properties [PMID:41149581, PMID:36500458].

Contexte

Sonneratia caseolaris is a fast-growing pioneer mangrove species widely distributed across the West-Indo Pacific region, including India, Bangladesh, Indonesia, China, Vietnam, and Thailand [PMID:41149581, PMID:34141477, PMID:38494260, PMID:41594876]. It can grow in both saltwater and freshwater environments [PMID:33665038].

Usages traditionnels

According to traditional folklore and medicinal usage, it is used as an astringent and antiseptic [PMID:23441048], and has a long history of use in traditional medicine for antioxidant, antimicrobial, and antifungal activities [PMID:42011309].

Composés actifs

The phytochemical profile is dominated by phenolic acids, flavonoids, and tannins, along with terpenoids, steroids, fatty acids, fatty alcohols, aldehydes, hydrocarbons, and polysaccharides [PMID:41149581]. Specific isolated flavonoids include luteolin and luteolin 7-O-β-glucoside [PMID:29435876]. Bark extracts have also been found to contain alkaloids and saponins [PMID:26417316].

Mécanisme d'action

The plant exhibits antioxidant activity through radical scavenging effects (e.g., DPPH) [PMID:29435876, PMID:36500458]. In fish models, it may activate the immune response, as evidenced by increased white blood cell counts [PMID:29684603].

Preuves cliniques

Preuve DOxidative Stress

Leaf extracts are classified as 'super-antioxidants' with activity comparable to ascorbic acid [PMID:36500458].

Preuve DBacterial Infections

Extracts show antibacterial activity against various pathogens, including Methicillin-resistant Staphylococcus aureus (MRSA) [PMID:36500458, PMID:23441048, PMID:26417316].

Preuve DDiarrhea

In mice with castor oil-induced diarrhea, fruit extract (250 mg/kg) showed 87.7% inhibition and delayed the onset of episodes [PMID:34316484]; another study noted significant reduction in stool count at 250 and 500 mg/kg [PMID:37096224].

Preuve DPain and Inflammation

Fruit extract revealed a significant peripheral analgesic effect in acetic acid-induced writhing models in mice [PMID:36060147].

Preuve DBlood Coagulation

Fruit extract significantly reduced blood clotting time in a dose-dependent manner (25, 50, and 100 mg/ml) [PMID:37096224].

Preuve D

Sécurité et effets indésirables

In African catfish, the highest dose of extract (3.17 mg/ml) was associated with the presence of inflammatory cells in the kidney, suggesting immune response activation [PMID:29684603]. No human safety data provided.

Synthèse des preuves

The current evidence is primarily based on in vitro studies and animal models (mice and fish), indicating strong antioxidant and antimicrobial potential, but there are no human clinical trials available.

Sources PubMed

1.PMID: 29435876 (2006) — Flavonoids from Sonneratia caseolaris. · Journal of natural medicines
2.PMID: 23441048 (2012) — Bactericidal Activity of Methanol Extracts of Crabapple Mangrove Tree (Sonneratia caseolaris Linn.) Against Multi-Drug Resistant Pathogens. · Indian journal of pharmaceutical sciences
3.PMID: 29684603 (2018) — Protective effect of apple mangrove Sonneratia caseolaris extract in Edwardsiella tarda-infected African catfish, Clarias gariepinus. · Fish & shellfish immunology
4.PMID: 36500458 (2022) — Indonesian Mangrove Sonneratia caseolaris Leaves Ethanol Extract Is a Potential Super Antioxidant and Anti Methicillin-Resistant Staphylococcus aureus Drug. · Molecules (Basel, Switzerland)
5.PMID: 41149581 (2025) — Phytochemistry and Pharmacological Potential of the Mangrove Plant Sonneratia caseolaris: A Comprehensive Review.

Sonneratia caseolaris

Sources et citations

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