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NootropicVérifié
Spanish Sage
Salvia lavandulaefolia
Troubles cognitifs dans la médecine populaire espagnole
PubMed · Chronic Supplementation with a Mix of <i>Salvia officinalis</i> and <i>Salvia lavandulaefolia</i> Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice. (2020)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Dernière mise à jour : April 2026
Calculer une dose sûre de Spanish Sage
Calculateur gratuit de posologie — doses adultes et enfants selon le poids.
How does Spanish sage improve memory and cognitive function?
Spanish sage (Salvia lavandulaefolia) appears to enhance cognitive function through multiple mechanisms. Its essential oil compounds, particularly cineole and camphor, exhibit anticholinesterase activity, which may help maintain acetylcholine levels in the brain—important for memory and learning. Additionally, Spanish sage demonstrates antioxidant and anti-inflammatory properties that may protect neural cells. Unlike common sage, Spanish sage lacks thujone, making it a potentially safer option for cognitive support. Evidence Level B supports these proposed mechanisms, though more research is needed to fully understand its neuroprotective effects.
Does Spanish sage interact with any medications?
Spanish sage may interact with medications metabolized by liver enzymes, particularly those processed by cytochrome P450 pathways. Due to its potential estrogenic effects, it may interfere with hormone therapies, birth control pills, and hormone-sensitive cancer treatments. Spanish sage may also enhance the effects of anticholinesterase medications used for Alzheimer's disease, such as donepezil. Individuals taking sedatives or CNS depressants should use caution, as Spanish sage may potentiate drowsiness. Always consult a healthcare provider before combining Spanish sage with prescription medications.
What is the recommended dosage for Spanish sage?
For cognitive support, the typical adult dosage of Spanish sage is 300–600 mg of standardized extract daily, taken in divided doses. Alternatively, 2–3 grams of dried leaves can be prepared as a tea, consumed up to three times daily. Standardized extracts should specify essential oil content, particularly cineole levels. Dosage may vary based on the specific product and intended use. Start with lower doses to assess tolerance, and consult a qualified healthcare practitioner for personalized recommendations, especially for long-term use.
Is Spanish sage safe during pregnancy and breastfeeding?
Spanish sage is considered unsafe during pregnancy and should be avoided. The essential oil compounds, including camphor and cineole, may stimulate uterine contractions or potentially harm fetal development. Due to its traditional use for stimulating menstruation, Spanish sage presents a risk of miscarriage. There is insufficient safety data for breastfeeding women, so avoidance is recommended. Women with estrogen-sensitive conditions, including certain breast cancers, endometriosis, or fibroids, should also avoid Spanish sage due to potential hormonal effects. Consult a healthcare provider for personalized guidance.
What is Spanish sage used for traditionally and in modern herbal medicine?
Spanish sage has been used traditionally in Spanish folk medicine for cognitive conditions, respiratory ailments, and fever reduction. Modern research has focused primarily on its potential for cognitive enhancement and Alzheimer's disease support, with Evidence Level B suggesting promising results for memory improvement. Unlike common sage, Spanish sage lacks thujone, making it a potentially safer alternative for therapeutic use. Its essential oil compounds—cineole, camphor, and linalool—contribute to its antimicrobial and anti-inflammatory properties, supporting respiratory health applications in traditional practice.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 27 articles PubMed · modèle : gemma4:31b
Résumé
Spanish Sage (Salvia lavandulaefolia) is an aromatic plant used traditionally to enhance memory and cognitive function [PMID:24836739, PMID:12895685].
Contexte
Salvia lavandulaefolia, also known as Spanish sage, is a species native to the Western Mediterranean [PMID:41829794]. It is a related species to Salvia officinalis with similar components, though it typically contains lower levels of thujone [PMID:30000875].
Usages traditionnels
It has a longstanding reputation in European herbal encyclopaedias and folk medicine as an agent to enhance memory and treat dementia problems [PMID:12895685, PMID:25474583, PMID:24836739]. In the Valencia Region of Spain, 29 medicinal uses have been reported for this species [PMID:28790914].
Composés actifs
The essential oil consists almost exclusively of monoterpenoids [PMID:20937617]. Major constituents include 1,8-cineole (up to 75.2%), camphor, alpha-pinene, beta-pinene, and bornyl acetate [PMID:10933142, PMID:25491340]. Other components include tannins, flavones, phenolic acids, phenylpropanoid glycosides, triterpenoids, and diterpenes [PMID:30000875].
Mécanisme d'action
S. lavandulaefolia and its monoterpenoid constituents (specifically 1,8-cineole and alpha-pinene) inhibit acetylcholinesterase (AChE) in vitro and in vivo [PMID:11697542, PMID:11926204, PMID:10933142]. It also demonstrates antioxidant, anti-inflammatory, and estrogenic effects [PMID:11697542, PMID:12895683, PMID:17168769].
Preuves cliniques
Preuve BCognitive performance and memory (healthy adults)
Acute administration of standardized essential oil improved memory and cognitive performance [PMID:12895685, PMID:20937617, PMID:15639154].
Preuve BMood (healthy adults)
Acute doses of essential oil led to positive modulation of mood [PMID:20937617, PMID:15639154].
Preuve BAlzheimer's Disease/Dementia
A pilot open-label study in patients with AD showed a significant increase in diastolic and systolic blood pressure in two patients, though this may have been due to preexisting hypertension [PMID:12895683].
Sécurité et effets indésirables
In general, sage is well tolerated, though occasional nausea, vomiting, abdominal pain, and dizziness have been reported [PMID:30000875]. The essential oil is considered an irritant for the user [PMID:39463783].
Grossesse et allaitement
No scientific studies were located to evaluate the effect of sage on milk supply, and no data exist on the safety of sage in nursing mothers or infants [PMID:30000875].
Synthèse des preuves
There is moderate evidence (Level B) from randomized controlled trials suggesting acute cognitive and mood enhancement in healthy adults. Preclinical evidence (Level D) supports its anticholinesterase and antioxidant properties. Evidence for clinical use in dementia is limited to pilot data.
Sources PubMed
1.PMID: 30000875 (2006) — Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice. · Nutrients
2.PMID: 12895685 (2003) — Salvia lavandulaefolia (Spanish sage) enhances memory in healthy young volunteers. · Pharmacology, biochemistry, and behavior
3.PMID: 24836739 (2014) — Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment and Alzheimer's disease. · CNS neuroscience & therapeutics
4.PMID: 28143625 (2017) — Potential benefits of phytochemicals against Alzheimer's disease. · The Proceedings of the Nutrition Society
5.PMID: 20937617 (2011) — Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 15639154 (2005) — Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers. · Physiology & behavior
7.PMID: 11697542 (2001) — In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimer's disease. · The Journal of pharmacy and pharmacology
8.PMID: 11926204 (2002) — Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo. · Phytomedicine : international journal of phytotherapy and phytopharmacology
9.PMID: 39463783 (2024) — Safety and efficacy of a feed additive consisting of an essential oil derived from the leaves of Salvia officinalis ssp. lavandulifolia (Vahl) Gams (Spanish sage oil) for use in all animal species (FEFANA asbl). · EFSA journal. European Food Safety Authority
10.PMID: 12895683 (2003) — Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. · Pharmacology, biochemistry, and behavior
11.PMID: 28790914 (2017) — Ethnopharmacological and Chemical Characterization of Salvia Species Used in Valencian Traditional Herbal Preparations. · Frontiers in pharmacology
12.PMID: 10933142 (2000) — In-vitro inhibition of human erythrocyte acetylcholinesterase by salvia lavandulaefolia essential oil and constituent terpenes. · The Journal of pharmacy and pharmacology
13.PMID: 39519941 (2024) — Agronomic Evaluation and Chemical Characterization of Salvia lavandulifolia Vahl. over 3 Consecutive Years Cultivated Under Harsh Climatic Conditions in Southeast Spain. · Plants (Basel, Switzerland)
14.PMID: 20874701 (2011) — The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzheimer's disease. · CNS & neurological disorders drug targets
15.PMID: 34926550 (2021) — Acute Effects of Salvia Supplementation on Cognitive Function in Athletes During a Fatiguing Cycling Exercise: A Randomized Cross-Over, Placebo-Controlled, and Double-Blind Study. · Frontiers in nutrition
16.PMID: 33466627 (2021) — The Acute and Chronic Cognitive Effects of a Sage Extract: A Randomized, Placebo Controlled Study in Healthy Humans. · Nutrients
17.PMID: 41471879 (2025) — Antifungal Efficacy of Selected Plant Essential Oils Against Clinical Canine Isolates Malassezia pachydermatis. · Microorganisms
18.PMID: 12895684 (2003) — Synergistic and antagonistic interactions of anticholinesterase terpenoids in Salvia lavandulaefolia essential oil. · Pharmacology, biochemistry, and behavior
19.PMID: 17168769 (2006) — The psychopharmacology of European herbs with cognition-enhancing properties. · Current pharmaceutical design
20.PMID: 20589925 (2010) — Differential effects of the aromas of Salvia species on memory and mood. · Human psychopharmacology
21.PMID: 34833945 (2021) — The Impact of Selected Essential Oils Applied to Non-Woven Viscose on Bacteria That Cause Lower Urinary Tract Infections-Preliminary Studies. · Molecules (Basel, Switzerland)
22.PMID: 25778348 (2015) — Protective properties of Salvia lavandulifolia Vahl. essential oil against oxidative stress-induced neuronal injury. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
23.PMID: 25474583 (2015) — Major selected monoterpenes α-pinene and 1,8-cineole found in Salvia lavandulifolia (Spanish sage) essential oil as regulators of cellular redox balance. · Pharmaceutical biology
24.PMID: 41829794 (2026) — LED Light Treatments Enhance the Synthesis of Bioactive Compounds in Salvia lavandulifolia Vahl. · Plants (Basel, Switzerland)
25.PMID: 29184240 (2017) — Essential oils as antibacterial agents against food-borne pathogens: Are they really as useful as they are claimed to be? · Journal of food science and technology
26.PMID: 25491340 (2014) — Comprehensive phenological description of essential-oil chemotypes of Salvia lavandulifolia Vahl grown under the same environmental conditions. · Chemistry & biodiversity
27.PMID: 24878100 (2014) — [Topographical-medical study on the Virgin of Guadalupe's ayate. Unpublished paper from a New Spanish sage]. · Revista medica del Instituto Mexicano del Seguro Social