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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Spigelia marilandica
North American native herb used by Native Americans and Eclectic physicians for intestinal worms and cardiac conditions.
Spigelia marilandica, commonly known as pinkroot, is a North American perennial herb traditionally used by Native Americans and Eclectic physicians as an anthelmintic and cardiac tonic. Its primary active compounds include the alkaloid spigeline, along with other alkaloids, resin, and tannins, which contribute to its antiparasitic and cardiotoxic properties. Evidence for its efficacy is limited (Grade C), with most data derived from traditional use and small pilot studies.
Spigeline, the principal alkaloid, exhibits neuromuscular blocking activity by competitively antagonizing nicotinic acetylcholine receptors at the neuromuscular junction, leading to paralysis of intestinal parasites. In higher doses, this action extends to cardiac muscle, causing negative inotropic effects and potential arrhythmias. Additionally, the herb's resin and tannins may contribute to mild astringent and anti-inflammatory actions, though these are not well-characterized. The cardiotonic effects historically described are likely due to low-dose stimulation of cardiac contractility, but the mechanism remains unclear and is overshadowed by toxicity risks.
North American native herb used by Native Americans and Eclectic physicians for intestinal worms and cardiac conditions.
Spigelia marilandica, commonly known as pinkroot, is a North American perennial herb traditionally used by Native Americans and Eclectic physicians as an anthelmintic and cardiac tonic. Its primary active compounds include the alkaloid spigeline, along with other alkaloids, resin, and tannins, which contribute to its antiparasitic and cardiotoxic properties. Evidence for its efficacy is limited (Grade C), with most data derived from traditional use and small pilot studies.
Spigeline, the principal alkaloid, exhibits neuromuscular blocking activity by competitively antagonizing nicotinic acetylcholine receptors at the neuromuscular junction, leading to paralysis of intestinal parasites. In higher doses, this action extends to cardiac muscle, causing negative inotropic effects and potential arrhythmias. Additionally, the herb's resin and tannins may contribute to mild astringent and anti-inflammatory actions, though these are not well-characterized. The cardiotonic effects historically described are likely due to low-dose stimulation of cardiac contractility, but the mechanism remains unclear and is overshadowed by toxicity risks.