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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Selaginella doederleinii Hieron is a traditional Chinese medicinal herb primarily used for the treatment of various cancers [PMID:35740086, PMID:35571075].
Contexte
Selaginella doederleinii Hieron is a perennial medicinal herb widely distributed in China [PMID:31892247]. It is categorized as a traditional Chinese herbal medicine [PMID:36874034].
Usages traditionnels
It is widely used in China to treat several ailments, primarily cancer [PMID:35740086], including throat carcinoma [PMID:36558956], nasopharyngeal carcinoma, lung cancer, and trophoblastic tumors [PMID:27292193].
Composés actifs
The herb contains biflavonoids (such as amentoflavone, palmatine, apigenin, and delicaflavone) [PMID:36874034], triflavonoids (selagintriflavonoids A-H) [PMID:27889245], and various flavonoids including seladoeflavones A-F [PMID:27889540]. Volatile components include terpenes, alkanes, alcohols, ketones, esters, aldehydes, ethers, aromatics, phenols, and furans [PMID:31892247].
Mécanisme d'action
Anticancer mechanisms involve the inhibition of cell proliferation and induction of caspase-dependent apoptosis [PMID:27292193], cell autophagic death via PI3K-Akt-mTOR and AMPKα-signaling pathways [PMID:33192508], and the Akt/Bad and IKKβ/NF-κB/COX-2 pathways in throat carcinoma [PMID:36558956]. It also demonstrates inhibitory effects on α-glucosidase, α-amylase, and xanthine oxidase [PMID:39456438], as well as BACE1 inhibition [PMID:27889245].
Preuves cliniques
Preuve DCancer (General/Various)
In vitro and in vivo studies show anti-carcinogenic activities and inhibition of cell proliferation in various cancer cell lines [PMID:35571075, PMID:28230759].
Preuve DThroat Carcinoma
Biflavonoid-rich extract inhibited cell infiltrative growth in Hep-2 and FaDu cells in vitro and showed anti-tumor effects in tumor-bearing nude mice [PMID:36558956].
Preuve DColorectal Cancer
Ethyl acetate extract induced cell autophagic death and apoptosis in HT29 and HCT116 cells in vitro and in vivo [PMID:33192508].
Preuve DLung Cancer (A549)
Ethyl acetate extract inhibits growth of A549 cells via caspase-dependent apoptosis [PMID:27292193].
Preuve DNasopharyngeal Carcinoma
Ethanol extract inhibited proliferation of CNE-1 and C666-1 cell lines [PMID:24311875].
Preuve DAlzheimer's Disease (Potential)
Sécurité et effets indésirables
One study evaluated the acute oral toxicity of the ethyl acetate extract, though specific adverse effect results were not detailed in the provided abstract [PMID:27292193].
Interactions médicamenteuses
The ethyl acetate extract from S. doederleinii and its constituents (Amentoflavone, Palmatine, Apigenin, Delicaflavone) were investigated for inhibitory effects on human cytochrome P450 (CYP450) enzymes to predict herb-drug interactions [PMID:36874034].
Synthèse des preuves
The evidence is currently limited to in vitro cell line studies and in vivo animal models (predominantly rodents), indicating strong preclinical potential for anticancer and enzyme-inhibitory activities, but lacking human clinical trial data.
Sources PubMed
1.PMID: 36874034 (2023) — Inhibitory effect of Selaginella doederleinii hieron on human cytochrome P450. · Frontiers in pharmacology
2.PMID: 35740086 (2022) — Flavonoids from Selaginella doederleinii Hieron and Their Antioxidant and Antiproliferative Activities. · Antioxidants (Basel, Switzerland)
3.PMID: 31109181 (2021) — New cytotoxic biflavones from Selaginella doederleinii. · Natural product research
4.PMID: 35255433 (2022) — Rapid screening for acetylcholinesterase inhibitors in Selaginella doederleinii Hieron by using functionalized magnetic Fe3O4 nanoparticles. · Talanta
5.PMID: 36042169 (2022) — Lactate Dehydrogenase-Inhibitors Isolated from Ethyl Acetate Extract of Selaginella doederleinii by Using a Rapid Screening Method with Enzyme-Immobilized Magnetic Nanoparticles.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Selagintriflavonoid A exhibited potent BACE1 inhibition (IC50 0.75 μM) in vitro [PMID:27889245].
· Frontiers in bioscience (Landmark edition)
6.PMID: 26410323 (2015) — Antioxidant and anticancer effection of the volatile oil from various habitats of Selaginella doederleinii Hieron. · Technology and health care : official journal of the European Society for Engineering and Medicine
7.PMID: 36558956 (2022) — A Biflavonoid-Rich Extract from Selaginella doederleinii Hieron. against Throat Carcinoma via Akt/Bad and IKKβ/NF-κB/COX-2 Pathways. · Pharmaceuticals (Basel, Switzerland)
8.PMID: 35571075 (2022) — Tissue Distribution, Excretion, and Interaction With Human Serum Albumin of Total Bioflavonoid Extract From Selaginella doederleinii. · Frontiers in pharmacology
9.PMID: 28230759 (2017) — Analysis of the Total Biflavonoids Extract from Selaginella doederleinii by HPLC-QTOF-MS and Its In Vitro and In Vivo Anticancer Effects. · Molecules (Basel, Switzerland)
10.PMID: 39456438 (2024) — Antidiabetic and Antigout Properties of the Ultrasound-Assisted Extraction of Total Biflavonoids from Selaginella doederleinii Revealed by In Vitro and In Silico Studies. · Antioxidants (Basel, Switzerland)
11.PMID: 33192508 (2020) — Ethyl Acetate Extract of Selaginella doederleinii Hieron Induces Cell Autophagic Death and Apoptosis in Colorectal Cancer via PI3K-Akt-mTOR and AMPKα-Signaling Pathways. · Frontiers in pharmacology
12.PMID: 29101819 (2018) — Simultaneous quantification of five biflavonoids in rat plasma by LC-ESI-MS/MS and its application to a comparatively pharmacokinetic study of Selaginella doederleinii Hieron extract in rats. · Journal of pharmaceutical and biomedical analysis
13.PMID: 27292193 (2016) — Ethyl acetate extract from Selaginella doederleinii Hieron inhibits the growth of human lung cancer cells A549 via caspase-dependent apoptosis pathway. · Journal of ethnopharmacology
14.PMID: 39747499 (2025) — The multi-target mechanism of action of Selaginella doederleinii Hieron in the treatment of nasopharyngeal carcinoma: a network pharmacology and multi-omics analysis. · Scientific reports
15.PMID: 27889245 (2017) — Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii. · Phytochemistry
16.PMID: 27889540 (2017) — Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii. · Fitoterapia
17.PMID: 31892247 (2019) — Analysis of the Volatile Components in Selaginella doederleinii by Headspace Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry. · Molecules (Basel, Switzerland)
18.PMID: 28387736 (2017) — Optimization of Ionic Liquid-Assisted Extraction of Biflavonoids from Selaginella doederleinii and Evaluation of Its Antioxidant and Antitumor Activity. · Molecules (Basel, Switzerland)
19.PMID: 24311875 (2013) — Effect of ethanol extract of Selaginella doederleinii Hieron on the proliferation of nasopharyngeal carcinoma CNE-1 and C666-1 cells. · African journal of traditional, complementary, and alternative medicines : AJTCAM
20.PMID: 24115163 (2014) — Preparative isolation of six anti-tumour biflavonoids from Selaginella doederleinii Hieron by high-speed counter-current chromatography. · Phytochemical analysis : PCA