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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Acmella caulirhiza
African species of the toothache plant used across sub-Saharan Africa for toothache, immune support, and as a general antimicrobial.
Spilanthes African (Acmella caulirhiza) is a medicinal herb from sub-Saharan Africa traditionally used for toothache, immune support, and antimicrobial therapy. Its primary active compound, spilanthol, acts as a local anesthetic and sialogogue, while N-isobutylamides, flavonoids, and polyacetylenes contribute to its anti-inflammatory and immunomodulatory effects.
Spilanthol exerts local anesthetic effects by blocking voltage-gated sodium channels (Nav1.7), inhibiting pain signal transmission. N-isobutylamides activate TRPV1 receptors, leading to desensitization and analgesia, and also stimulate salivary secretion via parasympathetic pathways. Flavonoids and polyacetylenes provide anti-inflammatory and antioxidant actions through inhibition of COX-2 and NF-κB pathways.
African species of the toothache plant used across sub-Saharan Africa for toothache, immune support, and as a general antimicrobial.
Spilanthes African (Acmella caulirhiza) is a medicinal herb from sub-Saharan Africa traditionally used for toothache, immune support, and antimicrobial therapy. Its primary active compound, spilanthol, acts as a local anesthetic and sialogogue, while N-isobutylamides, flavonoids, and polyacetylenes contribute to its anti-inflammatory and immunomodulatory effects.
Spilanthol exerts local anesthetic effects by blocking voltage-gated sodium channels (Nav1.7), inhibiting pain signal transmission. N-isobutylamides activate TRPV1 receptors, leading to desensitization and analgesia, and also stimulate salivary secretion via parasympathetic pathways. Flavonoids and polyacetylenes provide anti-inflammatory and antioxidant actions through inhibition of COX-2 and NF-κB pathways.