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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Acmella oleracea
Creates a remarkable electric tingling and numbing sensation; used worldwide for toothache and as an immune stimulant comparable to echinacea.
Spilanthes (Acmella oleracea) is a medicinal herb traditionally used for toothache and immune stimulation, known for its characteristic electric tingling and numbing sensation. Its primary active compounds include spilanthol, N-alkylamides, polyacetylenes, and flavonoids, which contribute to its analgesic, anti-inflammatory, and immunomodulatory effects. Evidence is limited (C-level) but supports its use for oral pain and as an immune adjuvant.
Spilanthol, the primary alkylamide, activates TRPA1 receptors on sensory neurons, producing the characteristic tingling and numbing sensation via calcium influx and subsequent desensitization. It also exhibits local anesthetic effects by blocking voltage-gated sodium channels (Nav1.7, Nav1.8). The N-alkylamides modulate immune function by inhibiting NF-κB and COX-2 pathways, reducing pro-inflammatory cytokines (TNF-α, IL-6) while enhancing phagocytosis and natural killer cell activity. Polyacetylenes contribute to antimicrobial effects against oral pathogens. The sialagogue action is mediated through parasympathetic stimulation of salivary glands.
Creates a remarkable electric tingling and numbing sensation; used worldwide for toothache and as an immune stimulant comparable to echinacea.
Spilanthes (Acmella oleracea) is a medicinal herb traditionally used for toothache and immune stimulation, known for its characteristic electric tingling and numbing sensation. Its primary active compounds include spilanthol, N-alkylamides, polyacetylenes, and flavonoids, which contribute to its analgesic, anti-inflammatory, and immunomodulatory effects. Evidence is limited (C-level) but supports its use for oral pain and as an immune adjuvant.
Spilanthol, the primary alkylamide, activates TRPA1 receptors on sensory neurons, producing the characteristic tingling and numbing sensation via calcium influx and subsequent desensitization. It also exhibits local anesthetic effects by blocking voltage-gated sodium channels (Nav1.7, Nav1.8). The N-alkylamides modulate immune function by inhibiting NF-κB and COX-2 pathways, reducing pro-inflammatory cytokines (TNF-α, IL-6) while enhancing phagocytosis and natural killer cell activity. Polyacetylenes contribute to antimicrobial effects against oral pathogens. The sialagogue action is mediated through parasympathetic stimulation of salivary glands.