Loading...
Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Loading...
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Stephania tetrandra
A TCM herb that clears heat, promotes urination, and expels wind-damp; used for joint pain, edema, and hypertension in Chinese medicine.
Stephania Root (Stephania tetrandra) is a traditional Chinese medicinal herb used for clearing heat, promoting urination, and expelling wind-damp. Its primary modern applications include anti-inflammatory effects for arthritis, diuretic action for edema, and antihypertensive activity via calcium channel blockade, attributed to the bisbenzylisoquinoline alkaloids tetrandrine and fangchinoline.
Tetrandrine and fangchinoline act as non-selective calcium channel blockers, inhibiting L-type and T-type calcium channels in vascular smooth muscle and cardiac myocytes, leading to vasodilation and reduced blood pressure. They also suppress NF-κB activation and reduce pro-inflammatory cytokine production (e.g., TNF-α, IL-6) in macrophages and synovial fibroblasts, contributing to anti-arthritic effects. Additionally, these alkaloids enhance diuresis by increasing renal blood flow and inhibiting tubular sodium reabsorption, possibly through modulation of aquaporin channels.
A TCM herb that clears heat, promotes urination, and expels wind-damp; used for joint pain, edema, and hypertension in Chinese medicine.
Stephania Root (Stephania tetrandra) is a traditional Chinese medicinal herb used for clearing heat, promoting urination, and expelling wind-damp. Its primary modern applications include anti-inflammatory effects for arthritis, diuretic action for edema, and antihypertensive activity via calcium channel blockade, attributed to the bisbenzylisoquinoline alkaloids tetrandrine and fangchinoline.
Tetrandrine and fangchinoline act as non-selective calcium channel blockers, inhibiting L-type and T-type calcium channels in vascular smooth muscle and cardiac myocytes, leading to vasodilation and reduced blood pressure. They also suppress NF-κB activation and reduce pro-inflammatory cytokine production (e.g., TNF-α, IL-6) in macrophages and synovial fibroblasts, contributing to anti-arthritic effects. Additionally, these alkaloids enhance diuresis by increasing renal blood flow and inhibiting tubular sodium reabsorption, possibly through modulation of aquaporin channels.