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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Strychnos ignatii
Philippine vine with seeds containing strychnine and brucine, used in Ayurveda and homeopathy in detoxified forms.
Strychnos ignatii is a Philippine vine whose seeds contain the potent neurotoxins strychnine and brucine, traditionally used in Ayurveda and homeopathy in highly diluted forms. In homeopathy, it is known as Ignatia amara and used for grief, anxiety, and digestive complaints, while raw seeds are extremely toxic and can cause convulsions and death. The plant's pharmacological activity is primarily due to strychnine's antagonism of glycine receptors in the spinal cord and brainstem.
Strychnine acts as a competitive antagonist at glycine receptors (GlyR), particularly in the spinal cord and brainstem, blocking inhibitory neurotransmission and leading to unchecked excitatory signaling, resulting in muscle spasms and convulsions. Brucine, a related alkaloid, has similar but less potent effects, also interacting with glycine and possibly GABA-A receptors. Loganin and caffeic acid contribute minor anti-inflammatory and antioxidant effects, but the primary mechanism of toxicity and therapeutic action (in extreme dilution) is glycine receptor blockade.
Philippine vine with seeds containing strychnine and brucine, used in Ayurveda and homeopathy in detoxified forms.
Strychnos ignatii is a Philippine vine whose seeds contain the potent neurotoxins strychnine and brucine, traditionally used in Ayurveda and homeopathy in highly diluted forms. In homeopathy, it is known as Ignatia amara and used for grief, anxiety, and digestive complaints, while raw seeds are extremely toxic and can cause convulsions and death. The plant's pharmacological activity is primarily due to strychnine's antagonism of glycine receptors in the spinal cord and brainstem.
Strychnine acts as a competitive antagonist at glycine receptors (GlyR), particularly in the spinal cord and brainstem, blocking inhibitory neurotransmission and leading to unchecked excitatory signaling, resulting in muscle spasms and convulsions. Brucine, a related alkaloid, has similar but less potent effects, also interacting with glycine and possibly GABA-A receptors. Loganin and caffeic acid contribute minor anti-inflammatory and antioxidant effects, but the primary mechanism of toxicity and therapeutic action (in extreme dilution) is glycine receptor blockade.