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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Symphytum x uplandicum
Hybrid comfrey with higher pyrrolizidine alkaloid content; used topically for musculoskeletal conditions.
Symphytum uplandicum, a hybrid comfrey, is used topically for musculoskeletal conditions such as muscle pain, joint inflammation, and bruises. Its primary active compounds include allantoin, pyrrolizidine alkaloids (PAs), mucilage, and rosmarinic acid. Evidence is limited (Level C), with most support from traditional use and small pilot studies.
Allantoin promotes cell proliferation and wound healing by stimulating fibroblast activity and increasing extracellular matrix synthesis. Pyrrolizidine alkaloids (PAs) may contribute to anti-inflammatory effects via inhibition of cyclooxygenase and lipoxygenase pathways, but also pose hepatotoxicity risk due to metabolic activation to toxic pyrroles. Rosmarinic acid provides additional antioxidant and anti-inflammatory actions by scavenging reactive oxygen species and modulating NF-κB signaling. Mucilage forms a protective film over tissues, reducing irritation and supporting tissue repair.
Hybrid comfrey with higher pyrrolizidine alkaloid content; used topically for musculoskeletal conditions.
Symphytum uplandicum, a hybrid comfrey, is used topically for musculoskeletal conditions such as muscle pain, joint inflammation, and bruises. Its primary active compounds include allantoin, pyrrolizidine alkaloids (PAs), mucilage, and rosmarinic acid. Evidence is limited (Level C), with most support from traditional use and small pilot studies.
Allantoin promotes cell proliferation and wound healing by stimulating fibroblast activity and increasing extracellular matrix synthesis. Pyrrolizidine alkaloids (PAs) may contribute to anti-inflammatory effects via inhibition of cyclooxygenase and lipoxygenase pathways, but also pose hepatotoxicity risk due to metabolic activation to toxic pyrroles. Rosmarinic acid provides additional antioxidant and anti-inflammatory actions by scavenging reactive oxygen species and modulating NF-κB signaling. Mucilage forms a protective film over tissues, reducing irritation and supporting tissue repair.