Loading...
Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Loading...
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Tabernaemontana divaricata
Pantropical ornamental with alkaloid-rich roots used in Ayurveda and Southeast Asian medicine.
Tabernaemontana divaricata is a pantropical ornamental shrub whose alkaloid-rich roots have been used in Ayurveda and Southeast Asian traditional medicine for eye conditions, fever, arthritis, and wound healing. Modern research (evidence level C) suggests potential anti-inflammatory, analgesic, antimicrobial, and antipyretic activities, attributed primarily to indole alkaloids such as coronaridine, voacangine, and ibogamine. Due to significant cardiac risks and lack of robust clinical data, this herb is restricted to professional use only.
The primary alkaloids (coronaridine, voacangine, ibogamine) interact with multiple neurotransmitter systems: they inhibit serotonin reuptake (SERT) and modulate sigma-1 receptors, contributing to analgesic and anti-inflammatory effects. Voacangine and ibogamine also block voltage-gated sodium and calcium channels, which may underlie both local anesthetic and cardiotoxic actions. Additionally, these compounds inhibit acetylcholinesterase and exhibit weak opioid receptor affinity, while their antimicrobial activity is linked to membrane disruption and inhibition of bacterial efflux pumps.
Pantropical ornamental with alkaloid-rich roots used in Ayurveda and Southeast Asian medicine.
Tabernaemontana divaricata is a pantropical ornamental shrub whose alkaloid-rich roots have been used in Ayurveda and Southeast Asian traditional medicine for eye conditions, fever, arthritis, and wound healing. Modern research (evidence level C) suggests potential anti-inflammatory, analgesic, antimicrobial, and antipyretic activities, attributed primarily to indole alkaloids such as coronaridine, voacangine, and ibogamine. Due to significant cardiac risks and lack of robust clinical data, this herb is restricted to professional use only.
The primary alkaloids (coronaridine, voacangine, ibogamine) interact with multiple neurotransmitter systems: they inhibit serotonin reuptake (SERT) and modulate sigma-1 receptors, contributing to analgesic and anti-inflammatory effects. Voacangine and ibogamine also block voltage-gated sodium and calcium channels, which may underlie both local anesthetic and cardiotoxic actions. Additionally, these compounds inhibit acetylcholinesterase and exhibit weak opioid receptor affinity, while their antimicrobial activity is linked to membrane disruption and inhibition of bacterial efflux pumps.