Tabernaemontana divaricata (Tabernaemontana divaricata): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Tabernaemontana divaricata work in the body?

Tabernaemontana divaricata contains indole alkaloids including coronaridine, voacangine, ibogamine, and dregamine, which are responsible for its pharmacological effects. These compounds may interact with various receptor systems in the body, potentially providing anti-inflammatory, analgesic, and wound-healing properties. Some alkaloids may affect cardiovascular and nervous system function. The evidence for specific mechanisms remains limited (Evidence Level C), with most understanding derived from traditional use and preliminary research rather than comprehensive clinical trials.

Does Tabernaemontana divaricata interact with any medications?

Tabernaemontana divaricata may interact with cardiovascular medications due to its potential cardiac effects at higher doses. The alkaloid content, including coronaridine and voacangine, could potentially interact with central nervous system medications. Due to limited clinical research (Evidence Level C), specific drug interaction data is not well-established. Patients taking heart medications, blood pressure medications, or CNS-active drugs should avoid this herb unless under professional supervision. Always consult a qualified healthcare provider before combining with prescription medications.

What is the correct dosage of Tabernaemontana divaricata root?

Traditional use suggests a root dosage of 0.5-2 grams for adults, though this should only be administered under professional guidance. Tabernaemontana divaricata is not recommended for self-medication due to its alkaloid content and potential toxicity at higher doses. The evidence level is C, meaning dosage recommendations are based primarily on traditional use rather than standardized clinical trials. Professional supervision is essential, as improper dosing may cause gastrointestinal irritation or cardiac effects.

Is Tabernaemontana divaricata safe during pregnancy and breastfeeding?

Tabernaemontana divaricata is considered unsafe during pregnancy and should be strictly avoided. The plant contains bioactive alkaloids such as coronaridine and voacangine that may cross the placental barrier and potentially affect fetal development. There is insufficient safety data for breastfeeding, so avoidance is recommended. This herb is also contraindicated for children. Women who are pregnant, planning pregnancy, or breastfeeding should not use Tabernaemontana divaricata under any circumstances.

What conditions does Tabernaemontana divaricata treat traditionally?

In Ayurvedic and Southeast Asian traditional medicine, Tabernaemontana divaricata has been used for eye conditions, fever, arthritis, skin conditions, and wound healing. The root, which is rich in indole alkaloids, is the primary part used medicinally. These traditional applications are based on centuries of empirical use, though scientific evidence remains limited (Evidence Level C). The plant's ornamental cultivation is widespread, but medicinal use requires professional guidance due to potential toxicity concerns.

What are the side effects and risks of Tabernaemontana divaricata?

Common side effects of Tabernaemontana divaricata include gastrointestinal irritation, particularly at higher doses. More serious concerns involve potential cardiac effects, especially when consumed in large quantities or by individuals with pre-existing cardiovascular conditions. The plant is contraindicated for people with heart disease, pregnant women, and children. Due to the alkaloid content and Evidence Level C rating, comprehensive safety data is limited. Professional supervision is strongly recommended, and self-medication should be avoided to prevent adverse reactions.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Tabernaemontana divaricata is a tropical garden plant used in traditional medicine for its analgesic, antibacterial, and CNS-related properties [PMID:18577786, PMID:38197339].

Contexte

Tabernaemontana divaricata is a common garden plant found in tropical countries and is a member of the Apocynaceae family [PMID:18577786, PMID:29575195].

Usages traditionnels

It is used by Adivasis of Kerala for analgesic and antibacterial purposes [PMID:38197339]. In Thai folklore medicine, it is used to prevent forgetfulness or improve memory [PMID:29322008]. Other traditional folklore benefits include use as an anti-epileptic, anti-mania, and brain tonic [PMID:26445709].

Composés actifs

The plant contains numerous alkaloids, including iboga-type, aspidosperma-type, and vobasinyl-ibogan-type indole alkaloids [PMID:31724098, PMID:34500306, PMID:23944995]. Specific identified alkaloids include voacangine, catharanthine, O-acetyl vallesamine [PMID:29883785], and coronaridine [PMID:40083579]. Non-alkaloidal constituents include enzymes, pyrolytic oil, hydrocarbons, terpenoids, phenolic acids [PMID:18577786], and camptothecin [PMID:34319175].

Mécanisme d'action

Flower methanolic extract exhibits anti-nociception that is attenuated by naloxone, L-Arginine, and glibenclamide [PMID:29883785]. Root extract inhibits neuronal acetylcholinesterase (AChE) activity and enhances Fos expression in the cerebral cortex [PMID:17023131]. Latex proteases exhibit thrombin-like and plasmin-like activities, including fibrinogenolytic activity and blood clot lysis [PMID:33569263, PMID:25603786].

Preuves cliniques

Preuve DDental Caries

Ethyl alcoholic leaf extract demonstrates antibacterial action against S. mutans and L. acidophilus [PMID:38197339]

Preuve DObsessive-Compulsive Behavior

Ethanolic leaf extract (100-300 mg/kg) dose-dependently inhibited marble-burying behavior in mice [PMID:26445709]

Preuve DPain/Nociception

Flower methanolic extract (125-500 mg/kg) showed anti-nociceptive effects in acetic acid and formalin-induced models [PMID:29883785]

Preuve DAlzheimer's/Cognitive Impairment

Root extract (250-1000 mg/kg) inhibited cortical acetylcholinesterase activity and reduced neuronal loss/oxidative stress induced by amyloid β25-35 in mice [PMID:17023131, PMID:29322008]

Preuve DCancer (In Vitro)

Certain isolated alkaloids (e.g., conophylline, taberdivarine C) showed cytotoxicity against various human cancer cell lines including HL-60, A-549, and MCF-7 [PMID:23944995, PMID:34500306, PMID:30169038]

Preuve D

Grossesse et allaitement

Flower extracts demonstrated estrogen-like activity and anti-implantation/early abortifacient activity in rat models [PMID:23302533].

Synthèse des preuves

The current evidence is primarily based on in vitro cell line studies and in vivo animal models (mice, rats, guinea pigs). There are no human clinical trials or systematic reviews of clinical efficacy provided in the abstracts.

Sources PubMed

1.PMID: 38197339 (2023) — Anticariogenic potential of tabernaemontana divaricata. · Indian journal of dental research : official publication of Indian Society for Dental Research
2.PMID: 18577786 (2008) — Ethnobotany & ethnopharmacology of Tabernaemontana divaricata. · The Indian journal of medical research
3.PMID: 38570006 (2024) — Insecticidal bisindole alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'. · Phytochemistry
4.PMID: 33562893 (2021) — Major Bioactive Alkaloids and Biological Activities of Tabernaemontana Species (Apocynaceae). · Plants (Basel, Switzerland)
5.PMID: 31724098 (2019) — New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata. · Natural products and bioprospecting

Tabernaemontana divaricata

Sources et citations

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