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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Artemisia dracunculus (tarragon) is a perennial Asteraceae species used globally as a spice and traditional remedy [PMID:33927629, PMID:21942448, PMID:30731940].
Contexte
Tarragon is a species of the Asteraceae family used as a spice in Asia, Europe, and the Americas [PMID:33927629]. Two widely used cultivars, Russian and French, differ in morphology, ploidy level, and chemical composition [PMID:21942448].
Usages traditionnels
In traditional Asian medicine (specifically Iran, Pakistan, Azerbaijan, and India), it is used for digestive system diseases, as an analgesic, hypnotic, antiepileptic, anti-inflammatory, antipyretic agent, and for treating helminthiasis [PMID:33927629].
Composés actifs
Key bioactive metabolites include essential oils (0.15-3.1%), coumarins (such as herniarine and 5,7-Dihydroxy-4-methylcoumarin), flavonoids (including kaempferol), phenolic acids, and alkamides (such as pellitorine, neopellitorine A, and neopellitorine B) [PMID:21942448, PMID:11730872, PMID:39800268, PMID:36082856]. Major essential oil constituents include eugenol, estragole (up to 82%), and methyleugenol (up to 39%) [PMID:21942448, PMID:38068651].
Mécanisme d'action
Tarragon extracts can inhibit reactive oxygen species (ROS), interleukin 8 (IL-8), and tumour necrosis factor α (TNF-α) production in human neutrophils [PMID:32903580]. Specific compounds like 5,7-Dihydroxy-4-methylcoumarin may enhance osteogenesis via the AKT1 pathway [PMID:39800268]. Certain alkamides act as dose-dependent inhibitors of cytochrome P450 3A4 (CYP3A4) activity [PMID:22738981].
Preuves cliniques
Preuve CInflammation and Pain
Pharmacological studies have confirmed anti-inflammatory and analgesic effects [PMID:33927629].
Preuve CNeuropathic Pain
Identified as a plant exhibiting protective effects in neuropathic pain models [PMID:29796216].
Preuve DHyperglycemia
In vivo rodent studies suggest potential antihyperglycemic effects [PMID:21942448]; extract PMI5011 improves blood glucose and insulin sensitivity via skeletal muscle [PMID:37686232].
Preuve DAutoimmune Encephalomyelitis (EAE)
Aqueous extract (500 mg/kg) significantly ameliorated clinical scores of EAE in mice [PMID:32245296].
Preuve DOsteoporosis
The compound 5,7-Dihydroxy-4-methylcoumarin (D4M) enhances osteoblastogenesis and ameliorates osteoporosis in a zebrafish model [PMID:39800268].
Sécurité et effets indésirables
Concerns exist regarding the hepatocarcinogenicity of estragole and methyleugenol [PMID:21942448, PMID:11077188, PMID:27761422]. However, no acute toxicity or mutagenic activity has been reported at doses relevant for human consumption [PMID:21942448]. Desiccated tarragon powder was not genotoxic in vivo at doses up to 6.25 g/kg bw [PMID:19913108]. A case of life-threatening glottal edema occurred in a florist with pre-existing sunflower allergy who showed strong sensitization against mugwort and tarragon [PMID:16285482].
Interactions médicamenteuses
Tarragon contains compounds that act as effective inhibitors of cytochrome P450 3A4 (CYP3A4) [PMID:22738981].
Synthèse des preuves
The evidence is primarily based on in vitro studies, animal models (rodents and zebrafish), and review articles. There is a lack of human clinical trials.
Sources PubMed
1.PMID: 33927629 (2021) — Artemisia dracunculus (Tarragon): A Review of Its Traditional Uses, Phytochemistry and Pharmacology. · Frontiers in pharmacology
2.PMID: 21942448 (2011) — Artemisia dracunculus L. (tarragon): a critical review of its traditional use, chemical composition, pharmacology, and safety. · Journal of agricultural and food chemistry
3.PMID: 23010670 (2013) — Toxicological and mutagenic analysis of Artemisia dracunculus (tarragon) extract. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
4.PMID: 11730872 (2001) — Alkamides from Artemisia dracunculus. · Phytochemistry
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
· Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
6.PMID: 40863944 (2025) — Effects of Tarragon Hydrodistillate and Essential Oil on Aquatic Ecosystems. · Toxics
7.PMID: 37112055 (2023) — Studies of the Tarragon Essential Oil Effects on the Characteristics of Doped Hydroxyapatite/Chitosan Biocomposites. · Polymers
8.PMID: 38247749 (2023) — Antimicrobial Activity of Artemisia dracunculus Oil-Loaded Agarose/Poly(Vinyl Alcohol) Hydrogel for Bio-Applications. · Gels (Basel, Switzerland)
9.PMID: 37686232 (2023) — Extract of Artemisia dracunculus L. Modulates Osteoblast Proliferation and Mineralization. · International journal of molecular sciences
10.PMID: 36234965 (2022) — Artemisia Species with High Biological Values as a Potential Source of Medicinal and Cosmetic Raw Materials. · Molecules (Basel, Switzerland)
11.PMID: 32234442 (2020) — Effect of chitosan-whey protein isolated coatings incorporated with tarragon Artemisia dracunculus essential oil on the quality of Scomberoides commersonnianus fillets at refrigerated condition. · International journal of biological macromolecules
12.PMID: 39199260 (2024) — Phytochemical Composition Antioxidant and Anti-Inflammatory Activity of Artemisia dracunculus and Artemisia abrotanum. · Antioxidants (Basel, Switzerland)
13.PMID: 22738981 (2012) — Effective cytochrome P450 (CYP) inhibitors isolated from tarragon (Artemisia dracunculus). · Bioscience, biotechnology, and biochemistry
14.PMID: 21821921 (2011) — Melanin biosynthesis inhibitors from Tarragon Artemisia dracunculus. · Bioscience, biotechnology, and biochemistry
15.PMID: 19913108 (2010) — Risk assessment of consumption of methylchavicol and tarragon: the genotoxic potential in vivo and in vitro. · Mutation research
16.PMID: 28729836 (2017) — An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes. · Frontiers in pharmacology
17.PMID: 32903580 (2020) — Inhibition of Neutrophil Functions and Antibacterial Effects of Tarragon (Artemisia dracunculus L.) Infusion-Phytochemical Characterization. · Frontiers in pharmacology
18.PMID: 29796216 (2018) — Medicinal herbs in the treatment of neuropathic pain: a review. · Iranian journal of basic medical sciences
19.PMID: 39800268 (2025) — 5,7-Dihydroxy-4-Methylcoumarin enhances osteogenesis and ameliorates osteoporosis via the AKT1 pathway. · Biochemical pharmacology
20.PMID: 18555848 (2008) — Strategies for assessment of botanical action on metabolic syndrome in the mouse and evidence for a genotype-specific effect of Russian tarragon in the regulation of insulin sensitivity. · Metabolism: clinical and experimental
21.PMID: 11077188 (2000) — Constituents of aromatic plants: II. Estragole. · Fitoterapia
22.PMID: 36082856 (2022) — Anticancer Properties of Kaempferol on Cellular Signaling Pathways. · Current topics in medicinal chemistry
23.PMID: 27761422 (2016) — Estragole and methyl-eugenol-free extract of Artemisia dracunculus possesses immunomodulatory effects. · Avicenna journal of phytomedicine
24.PMID: 32245296 (2019) — The Effect of Aqueous Extract of Tarragon on Clinical Symptoms and T Cell Differentiation in Experimental Autoimmune Encephalomyelitis. · Iranian journal of allergy, asthma, and immunology
25.PMID: 35161282 (2022) — Characterization of Ingredients Incorporated in the Traditional Mixed-Salad of the Capuchin Monks. · Plants (Basel, Switzerland)
26.PMID: 30731940 (2011) — Fusarium Crown and Root Rot of Tarragon in California Caused by Fusarium solani. · Plant disease
27.PMID: 38068651 (2023) — Unraveling the Potential of Organic Oregano and Tarragon Essential Oils: Profiling Composition, FT-IR and Bioactivities. · Plants (Basel, Switzerland)