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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Taxus baccata
Ancient European tree source of paclitaxel (Taxol); all parts except fruit pulp extremely toxic.
Taxus baccata (yew) is an ancient European tree whose bark and needles contain the potent anticancer agent paclitaxel (Taxol), along with highly toxic taxine alkaloids that can cause fatal cardiac arrhythmias. Modern medicine uses purified paclitaxel as a first-line chemotherapy for ovarian, breast, and lung cancers, while the raw plant remains deadly if ingested. Key active compounds include paclitaxel, baccatin III, and the cardiotoxic taxines A and B.
Paclitaxel binds to the β-tubulin subunit of microtubules, promoting polymerization and stabilizing microtubules against depolymerization, thereby disrupting mitotic spindle function and inducing cell cycle arrest at G2/M phase. Taxine A and B inhibit cardiac sodium and calcium channels, leading to bradycardia, hypotension, and ventricular fibrillation. Baccatin III serves as a precursor for semi-synthetic paclitaxel production via esterification of the side chain.
Ancient European tree source of paclitaxel (Taxol); all parts except fruit pulp extremely toxic.
Taxus baccata (yew) is an ancient European tree whose bark and needles contain the potent anticancer agent paclitaxel (Taxol), along with highly toxic taxine alkaloids that can cause fatal cardiac arrhythmias. Modern medicine uses purified paclitaxel as a first-line chemotherapy for ovarian, breast, and lung cancers, while the raw plant remains deadly if ingested. Key active compounds include paclitaxel, baccatin III, and the cardiotoxic taxines A and B.
Paclitaxel binds to the β-tubulin subunit of microtubules, promoting polymerization and stabilizing microtubules against depolymerization, thereby disrupting mitotic spindle function and inducing cell cycle arrest at G2/M phase. Taxine A and B inhibit cardiac sodium and calcium channels, leading to bradycardia, hypotension, and ventricular fibrillation. Baccatin III serves as a precursor for semi-synthetic paclitaxel production via esterification of the side chain.