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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Cascabela thevetia
Tropical ornamental tree; cardiac glycoside-rich seeds are extremely toxic but used carefully in folk medicine.
Thevetia peruviana (Cascabela thevetia) is a tropical ornamental tree whose seeds contain potent cardiac glycosides including thevetin A, thevetin B, peruvoside, and neriifolin. Despite historical use in traditional medicine for cardiac conditions and external skin ailments, the plant is extremely toxic and internal use is potentially lethal. Modern interest is limited to research as a source of cardiac glycosides, with no safe therapeutic application.
The cardiac glycosides of Thevetia peruviana inhibit the Na+/K+-ATPase pump in cardiac myocytes, leading to increased intracellular sodium and subsequent calcium influx via the Na+/Ca2+ exchanger. This enhances myocardial contractility (positive inotropy) but also increases automaticity and can trigger fatal arrhythmias. The compounds also exhibit digitalis-like effects on the AV node, reducing conduction velocity. At toxic doses, these mechanisms culminate in ventricular tachycardia, fibrillation, and cardiac arrest.
Tropical ornamental tree; cardiac glycoside-rich seeds are extremely toxic but used carefully in folk medicine.
Thevetia peruviana (Cascabela thevetia) is a tropical ornamental tree whose seeds contain potent cardiac glycosides including thevetin A, thevetin B, peruvoside, and neriifolin. Despite historical use in traditional medicine for cardiac conditions and external skin ailments, the plant is extremely toxic and internal use is potentially lethal. Modern interest is limited to research as a source of cardiac glycosides, with no safe therapeutic application.
The cardiac glycosides of Thevetia peruviana inhibit the Na+/K+-ATPase pump in cardiac myocytes, leading to increased intracellular sodium and subsequent calcium influx via the Na+/Ca2+ exchanger. This enhances myocardial contractility (positive inotropy) but also increases automaticity and can trigger fatal arrhythmias. The compounds also exhibit digitalis-like effects on the AV node, reducing conduction velocity. At toxic doses, these mechanisms culminate in ventricular tachycardia, fibrillation, and cardiac arrest.