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Bupleurum falcatum
Japanese Kampo and TCM herb used for liver conditions, alternating fever and chills, and immune modulation; component of Sho-saiko-to formula.
Bupleurum falcatum (Thorowax) is a foundational herb in Japanese Kampo and Traditional Chinese Medicine, primarily used for liver disorders, alternating fever and chills, and immune modulation. It is a key component of the formula Sho-saiko-to. Its therapeutic effects are largely attributed to saikosaponins A, C, and D, along with flavonoids like rutin and quercetin.
Saikosaponins, particularly saikosaponin D, exert hepatoprotective effects by inhibiting hepatic stellate cell activation and reducing collagen deposition via suppression of TGF-β1 signaling. They also modulate immune function by enhancing natural killer cell activity and promoting Th1 cytokine responses. Anti-inflammatory actions involve inhibition of NF-κB and COX-2 pathways, while anticancer properties are linked to induction of apoptosis through caspase-3 activation and cell cycle arrest at G1 phase.
Japanese Kampo and TCM herb used for liver conditions, alternating fever and chills, and immune modulation; component of Sho-saiko-to formula.
Bupleurum falcatum (Thorowax) is a foundational herb in Japanese Kampo and Traditional Chinese Medicine, primarily used for liver disorders, alternating fever and chills, and immune modulation. It is a key component of the formula Sho-saiko-to. Its therapeutic effects are largely attributed to saikosaponins A, C, and D, along with flavonoids like rutin and quercetin.
Saikosaponins, particularly saikosaponin D, exert hepatoprotective effects by inhibiting hepatic stellate cell activation and reducing collagen deposition via suppression of TGF-β1 signaling. They also modulate immune function by enhancing natural killer cell activity and promoting Th1 cytokine responses. Anti-inflammatory actions involve inhibition of NF-κB and COX-2 pathways, while anticancer properties are linked to induction of apoptosis through caspase-3 activation and cell cycle arrest at G1 phase.