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PubMed · Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity. (2015)
PubMed · A comprehensive metabolome profiling of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica to explore the medicinal potential of Triphala. (2024)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Dernière mise à jour : April 2026
Calculer une dose sûre de Triphala Digestive
Calculateur gratuit de posologie — doses adultes et enfants selon le poids.
Triphala works through multiple complementary mechanisms. The three fruits—Amalaki (Emblica officinalis), Bibhitaki (Terminalia bellirica), and Haritaki (Terminalia chebula)—contain bioactive compounds including gallic acid, ellagic acid, and chebulinic acid. Haritaki stimulates intestinal peristalsis to promote bowel movements, while Amalaki supports intestinal mucosal integrity. The formula provides gentle osmotic laxative effects by drawing water into the bowel. Evidence Level B supports these mechanisms for constipation relief and digestive cleansing.
Can I take Triphala with prescription medications?
Triphala may interact with certain medications due to its effects on gastrointestinal transit time and drug absorption. Its laxative action can potentially reduce absorption of oral medications by accelerating gut transit. Patients taking anticoagulants, antidiabetic drugs, or medications with narrow therapeutic indices should exercise caution. Clinical interaction data remains limited (Evidence Level D). Always separate Triphala administration from prescription medications by at least 2 hours and consult a healthcare provider before combining.
What is the recommended Triphala dosage for adults?
The standard adult dosage for Triphala powder is 3-6 grams mixed in warm water, taken before bed. This timing aligns with the body's natural elimination rhythm, typically producing bowel movements the following morning. Start with 3 grams to assess tolerance, then increase gradually as needed. Triphala is also available in tablet or capsule form, typically 500-1000mg per dose. Evidence Level B supports this dosing range for constipation and digestive support.
Is Triphala safe during pregnancy and breastfeeding?
Triphala is contraindicated during pregnancy and should be avoided completely. Haritaki (Terminalia chebula), one of the three constituent fruits, possesses emmenagogue properties that may stimulate uterine contractions and potentially cause miscarriage. The laxative effects can also lead to dehydration and electrolyte disturbances harmful during pregnancy. Breastfeeding women should likewise avoid Triphala due to insufficient safety data. Evidence Level D based on traditional contraindications. Seek pregnancy-safe alternatives for constipation relief.
What are the common side effects of Triphala?
Common initial side effects include loose stools, abdominal discomfort, and increased gas as the digestive system adjusts. These effects typically resolve within 3-5 days of consistent use. Starting with a lower dose (3g) helps minimize discomfort. Discontinue use if severe diarrhea, cramping, or dehydration occurs. Triphala is contraindicated in individuals with diarrhea or dysentery, as it may exacerbate these conditions. Evidence Level B supports its general safety profile when used appropriately.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Triphala is a traditional Ayurvedic formulation composed of three fruits—Emblica officinalis, Terminalia bellirica, and Terminalia chebula—known for its antioxidant and anti-diabetic properties [PMID:35168075, PMID:34149415].
Contexte
Triphala is a polyherbal Ayurvedic remedy consisting of the outer pericarp of Haritaki (Terminalia chebula), Vibhitaki (Terminalia bellirica), and Amalaki (Emblica officinalis/Phyllanthus emblica) [PMID:41151054, PMID:39738152]. It is considered a 'Rasayana' in traditional Indian medicine used to rejuvenate debilitated organs [PMID:23239004].
Usages traditionnels
In Ayurveda, Triphala is used to treat various gastrointestinal disorders, promote digestion, detoxification, and overall wellness [PMID:23239004, PMID:39738152]. In Thai traditional medicine, a similar recipe (Tri-sa-maw) is used for treating fever, as an expectorant, for periodic maintenance, and tight stomach relief [PMID:26211099].
Composés actifs
Triphala contains over 150 bioactive compounds [PMID:41151054]. Key identified phytochemicals include polyphenols, ellagic acid, chebulinic acid, gallic acid, and corilagin [PMID:39738152, PMID:41151054]. Analysis of extracts has also shown the presence of total phenolic compounds, total flavonoids, hydrolyzable tannins, and condensed tannins [PMID:36970454].
Mécanisme d'action
Triphala exhibits potent antioxidant and free radical scavenging activities [PMID:23239004, PMID:32670108]. In diabetic nephropathy models, it acts via the inhibition of TGF-β1 and oxidative stress [PMID:32674108]. In dengue virus infection models, it has been shown to diminish IL-6 and CXCL-10 expressions, which are markers of the cytokine storm [PMID:34959637].
Preuves cliniques
Preuve DDiabetic Retinopathy
Significantly reduced plasma glucose and lactate dehydrogenase levels in diabetic rats [PMID:35168075]
Preuve DDiabetic Neuropathy
Mitigated diabetic neuropathy in rats, affecting parameters such as plasma glucose and motor nerve conduction velocity [PMID:34149415]
Preuve DDiabetic Nephropathy
Ameliorated nephropathy in rats by inhibiting TGF-β1 and oxidative stress [PMID:32674108]
Preuve DEnteric Bacterial Pathogens
Demonstrated potent antibacterial activity against S. epidermidis, P. vulgaris, S. aureus, E. coli, P. aeruginosa, and S. typhi [PMID:22171288]
Preuve BDenture Candida albicans
Evaluated for antifungal properties as a denture cleanser [PMID:28300045]
Preuve DBrass-induced Heavy Metal Toxicity
Used in a pilot study for the management of high serum levels of copper, zinc, and lead in workers [PMID:34690043]
Sécurité et effets indésirables
A study in Sprague-Dawley rats evaluating acute (5000 mg/kg) and chronic (up to 2400 mg/kg for 270 days) oral toxicity of Maha Pigut Triphala was conducted to assess abnormalities in symptoms and biochemistry [PMID:39765672].
Synthèse des preuves
The majority of evidence is derived from in vitro studies and animal models (rats), indicating strong antioxidant, antibacterial, and anti-diabetic potential. Limited clinical pilot data exists for heavy metal toxicity and denture cleansing.
2.PMID: 34149415 (2021) — Triphala Churna-A Traditional Formulation in Ayurveda Mitigates Diabetic Neuropathy in Rats. · Frontiers in pharmacology
3.PMID: 22171288 (2011) — Antibacterial activity of some Indian Ayurvedic preparations against enteric bacterial pathogens. · Journal of advanced pharmaceutical technology & research
4.PMID: 32674108 (2020) — Triphala Ameliorates Nephropathy via Inhibition of TGF-β1 and Oxidative Stress in Diabetic Rats. · Pharmacology
5.PMID: 28300045 (2017) — "Nature cures:" An alternative herbal formulation as a denture cleanser. · Annals of African medicine
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Inhibited virus production and diminished cytokine storm markers in Huh7 hepatoma cells and Vero cells [PMID:34959637]
6.PMID: 39738152 (2024) — A comprehensive metabolome profiling of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica to explore the medicinal potential of Triphala. · Scientific reports
7.PMID: 23239004 (2012) — Scientific validation of the ethnomedicinal properties of the Ayurvedic drug Triphala: a review. · Chinese journal of integrative medicine
8.PMID: 34690043 (2021) — Ayurveda intervention for brass-induced heavy metal toxicity: A report from the single-arm pilot study. · Journal of Ayurveda and integrative medicine
9.PMID: 39765672 (2024) — Safety Evaluation for Acute and Chronic Oral Toxicity of Maha Pigut Triphala Contains Three Medicinal Fruits in Sprague-Dawley Rats. · Biology
10.PMID: 34959637 (2021) — Triphala in Traditional Ayurvedic Medicine Inhibits Dengue Virus Infection in Huh7 Hepatoma Cells. · Pharmaceuticals (Basel, Switzerland)
11.PMID: 23737641 (2013) — Rasayana drugs from the Ayurvedic system of medicine as possible radioprotective agents in cancer treatment. · Integrative cancer therapies
12.PMID: 36970454 (2023) — Efficacy of Triphala extracts on the changes of obese fecal microbiome and metabolome in the human gut model. · Journal of traditional and complementary medicine
13.PMID: 26211099 (2015) — Analgesic and antipyretic activity of Tri-sa-maw recipe. · Journal of the Medical Association of Thailand = Chotmaihet thangphaet
14.PMID: 41151054 (2026) — The Multifaceted Benefits of Triphala: Uncovering Phytochemical and Pharmacological Properties From Antiquity to Modern Times. · Chemistry & biodiversity