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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Tripterygium wilfordii
Climbing vine from China and Taiwan with extraordinary anti-inflammatory properties, used in TCM for severe arthritis.
Tripterygium wilfordii, a climbing vine native to East Asia, is a potent anti-inflammatory and immunosuppressive herb used in Traditional Chinese Medicine for severe rheumatoid arthritis and autoimmune conditions. Its primary active compounds include the diterpenoid triepoxide triptolide, the quinone methide triterpenoid celastrol, and various alkaloids, which collectively modulate multiple inflammatory pathways. Despite its efficacy, the herb has a narrow therapeutic window and significant toxicity, requiring strict medical supervision.
Triptolide inhibits nuclear factor-kappa B (NF-κB) activation, thereby suppressing pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. It also inhibits the JAK/STAT signaling pathway and reduces T-cell proliferation and activation. Celastrol acts as a potent inhibitor of the proteasome and heat shock response, further modulating immune responses. Additionally, these compounds induce apoptosis in activated immune cells and inhibit angiogenesis, contributing to their anti-arthritic effects.
Climbing vine from China and Taiwan with extraordinary anti-inflammatory properties, used in TCM for severe arthritis.
Tripterygium wilfordii, a climbing vine native to East Asia, is a potent anti-inflammatory and immunosuppressive herb used in Traditional Chinese Medicine for severe rheumatoid arthritis and autoimmune conditions. Its primary active compounds include the diterpenoid triepoxide triptolide, the quinone methide triterpenoid celastrol, and various alkaloids, which collectively modulate multiple inflammatory pathways. Despite its efficacy, the herb has a narrow therapeutic window and significant toxicity, requiring strict medical supervision.
Triptolide inhibits nuclear factor-kappa B (NF-κB) activation, thereby suppressing pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. It also inhibits the JAK/STAT signaling pathway and reduces T-cell proliferation and activation. Celastrol acts as a potent inhibitor of the proteasome and heat shock response, further modulating immune responses. Additionally, these compounds induce apoptosis in activated immune cells and inhibit angiogenesis, contributing to their anti-arthritic effects.