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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Veratrum californicum
Western North American plant; causes severe birth defects (cyclopia) in livestock; source of cyclopamine.
Veratrum californicum is a highly toxic plant native to western North America, known for causing severe birth defects such as cyclopia in livestock. Its primary active compound, cyclopamine, is a potent inhibitor of the Hedgehog signaling pathway, making it a valuable research tool but not suitable for therapeutic use.
Cyclopamine and related steroidal alkaloids (e.g., jervine) inhibit the Hedgehog signaling pathway by binding to Smoothened (Smo), a G protein-coupled receptor, thereby blocking downstream activation of Gli transcription factors. This disrupts embryonic patterning and can lead to teratogenic effects. Additionally, veratramine modulates ion channels, contributing to neurotoxicity.
Western North American plant; causes severe birth defects (cyclopia) in livestock; source of cyclopamine.
Veratrum californicum is a highly toxic plant native to western North America, known for causing severe birth defects such as cyclopia in livestock. Its primary active compound, cyclopamine, is a potent inhibitor of the Hedgehog signaling pathway, making it a valuable research tool but not suitable for therapeutic use.
Cyclopamine and related steroidal alkaloids (e.g., jervine) inhibit the Hedgehog signaling pathway by binding to Smoothened (Smo), a G protein-coupled receptor, thereby blocking downstream activation of Gli transcription factors. This disrupts embryonic patterning and can lead to teratogenic effects. Additionally, veratramine modulates ion channels, contributing to neurotoxicity.