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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
How does Warburgia ugandensis work as an antimicrobial?
Warburgia ugandensis contains bioactive sesquiterpene dialdehydes, particularly warburganal and polygodial, which are responsible for its antimicrobial effects. These compounds disrupt bacterial and fungal cell membranes, leading to cell death. Polygodial has demonstrated broad-spectrum activity against various pathogens including bacteria responsible for respiratory infections and certain parasites. The pungent compounds also stimulate digestive secretions, contributing to its traditional use for gastrointestinal complaints. Evidence level: C (preclinical and traditional use data).
Does Warburgia ugandensis interact with any medications?
There is limited clinical research on Warburgia ugandensis drug interactions. Due to its irritant properties and effects on gastric mucosa, it may theoretically interact with medications affecting the gastrointestinal tract, including NSAIDs, antacids, and acid-suppressing drugs. The herb's antimicrobial properties could potentially alter gut microbiome composition, which may affect the metabolism of certain drugs. Patients taking prescription medications should consult a healthcare provider before using Warburgia ugandensis. Evidence level: C (theoretical based on pharmacological properties).
What is the correct dosage of Warburgia ugandensis bark?
The traditional adult dosage for Warburgia ugandensis is one cup of bark decoction taken twice daily. To prepare, approximately 10-15 grams of dried bark is boiled in water for 15-20 minutes, then strained before consumption. Due to the herb's pungent nature and potential for gastric irritation, it is advisable to take it with food. Dosage should not exceed traditional recommendations without professional guidance. Evidence level: C (traditional use).
Is Warburgia ugandensis safe during pregnancy and breastfeeding?
Warburgia ugandensis is contraindicated during pregnancy and lactation. The sesquiterpene dialdehydes, including warburganal and polygodial, have uterine-stimulating properties that may increase the risk of miscarriage or premature labor. Additionally, these compounds can pass into breast milk and may cause gastrointestinal irritation in nursing infants. Women who are pregnant, planning to become pregnant, or breastfeeding should avoid this herb entirely. Evidence level: C (traditional contraindication and pharmacological evidence).
What are the side effects of Warburgia ugandensis?
The most common side effects of Warburgia ugandensis are related to its pungent, irritating properties. Users may experience a burning sensation in the mouth and throat, gastric discomfort, nausea, and at higher doses, vomiting or diarrhea. Individuals with gastric ulcers or sensitive digestive systems should avoid this herb as it may exacerbate gastrointestinal irritation. Taking the herb with food may help reduce these effects. Evidence level: C (traditional use reports).
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Warburgia ugandensis, also known as the East African greenheart or pepper bark tree, is a medicinal plant native to Africa with documented antimicrobial, anti-inflammatory, and antileishmanial properties [PMID:31848891, PMID:21461155].
Contexte
Warburgia ugandensis (Family: Canellaceae) is a medicinal tree widely distributed across Eastern, Central, and Southern Africa [PMID:31676401, PMID:25698247].
Usages traditionnels
Traditionally used in African countries to treat pneumonia, asthma, malaria, candidiasis, skin infections, HIV-opportunistic infections, diarrhea, measles, respiratory infections, tooth aches, venereal diseases, fevers, and aches [PMID:31848891, PMID:31676401]. It is also used in the management of sexual dysfunction, infertility, and to improve virility in the East African Community [PMID:37600549].
Composés actifs
The plant contains abundant terpenoids, including drimane and coloratane type sesquiterpenoids (such as ugandensial, warburganal, mukaadial, and polygodial) [PMID:31848891, PMID:30031002]. Other secondary metabolites include tannins, flavonoids (specifically flavonol glycosides like kaempferol and quercetin), saponins, steroids, mannitol, and lignanamides [PMID:31848891, PMID:14559287, PMID:33804549].
Mécanisme d'action
Certain sesquiterpenes (ugandensidial and muzigadial) inhibit 12-LOX and 5-LOX enzymes, reducing the biosynthesis of 12(S)-HETE and leukotriene B4 [PMID:16732527]. Polygodial acts by damaging the cell membrane of fungi, potentially facilitating the transmembrane transport of other chemicals [PMID:3286823]. In A549 lung cancer cells, dimethyl carbonate extracts induce ROS generation leading to G0/G1 cell cycle arrest [PMID:34679694].
Preuves cliniques
Preuve DLeishmaniasis (L. major)
Oral administration of extracts reduced lesion size in BALB/c mice; intraperitoneal injection also showed healing by day 42 [PMID:20209014]. Extracts demonstrated in vitro antileishmanial activity with an IC50 of 1.114 mg/ml [PMID:21461155].
Preuve DMalaria (Plasmodium knowlesi and P. berghei)
Extracts showed in vitro anti-plasmodial activity (IC50 3.14 to 75 microg/ml) and provided over 80% survivorship in treated BALB/c mice [PMID:20435133].
Preuve DFungal and Bacterial Infections
Extracts exhibit strong antimicrobial activity against a broad spectrum of pathogens, including biofilm-inhibiting properties against Candida and staphylococci [PMID:31848891, PMID:31676401].
Preuve DHelminthiasis
Purified compounds warburganal and polygodial demonstrated anthelmintic activity against C. elegans [PMID:30031002].
Preuve DNon-small cell lung cancer (A549 cells)
Dimethyl carbonate extract inhibited proliferation in a time- and dose-dependent manner via ROS generation and G0/G1 arrest [PMID:34679694].
Sécurité et effets indésirables
Cytotoxicity studies using the human glioblastoma cell line U87.CD4.CXCR4 were conducted to determine the CC50 of extracts used by PLHIV in Uganda [PMID:35586188].
Synthèse des preuves
The current evidence consists primarily of in vitro studies, animal models (mice), and literature reviews. There are no randomized controlled trials (RCTs) or human clinical trials provided in the source abstracts.
Sources PubMed
1.PMID: 37895122 (2023) — Plant Extracts as Skin Care and Therapeutic Agents. · International journal of molecular sciences
2.PMID: 31848891 (2021) — Ethnopharmacological Potentials of Warburgia ugandensis on Antimicrobial Activities. · Chinese journal of integrative medicine
3.PMID: 24188508 (2014) — The genus Warburgia: a review of its traditional uses and pharmacology. · Pharmaceutical biology
4.PMID: 25698247 (2015) — Warburgia: a comprehensive review of the botany, traditional uses and phytochemistry. · Journal of ethnopharmacology
5.PMID: 24624248 (2014) — Immunostimulatory responses to crude extracts of Warburgia ugandensis (Sprague) subsp ugandensis (Canellaceae) by BALB/c mice infected with Leishmania major. · The Pan African medical journal
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 12789119 (2001) — Antibacterial and antifungal activities of extracts of Zanthoxylum chalybeum and Warburgia ugandensis, Ugandan medicinal plants. · African health sciences
7.PMID: 31676401 (2020) — Biofilm inhibiting properties of compounds from the leaves of Warburgia ugandensis Sprague subsp ugandensis against Candida and staphylococcal biofilms. · Journal of ethnopharmacology
8.PMID: 33915848 (2021) — Identification of Anti-Inflammatory and Anti-Proliferative Neolignanamides from Warburgia ugandensis Employing Multi-Target Affinity Ultrafiltration and LC-MS. · Pharmaceuticals (Basel, Switzerland)
9.PMID: 38816414 (2024) — The chromosome-level genomes of the herbal magnoliids Warburgia ugandensis and Saururus chinensis. · Scientific data
10.PMID: 30031002 (2018) — Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial. · International journal for parasitology
11.PMID: 21461155 (2010) — In vitro effects of Warburgia ugandensis, Psiadia punctulata and Chasmanthera dependens on Leishmania major promastigotes. · African journal of traditional, complementary, and alternative medicines : AJTCAM
13.PMID: 33804549 (2021) — New Lignanamides with Antioxidant and Anti-Inflammatory Activities Screened Out and Identified from Warburgia ugandensis Combining Affinity Ultrafiltration LC-MS with SOD and XOD Enzymes. · Antioxidants (Basel, Switzerland)
14.PMID: 34961234 (2021) — Warburgia ugandensis Leaf and Bark Extracts: An Alternative to Copper as Fungicide against Downy Mildew in Organic Viticulture? · Plants (Basel, Switzerland)
16.PMID: 16153670 (2005) — Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity. · Phytochemistry
17.PMID: 20209014 (2009) — In vivo efficacy of oral and intraperitoneal administration of extracts of Warburgia ugandensis (Canellaceae) in experimental treatment of Old World cutaneous leishmaniasis caused by Leishmania major. · African journal of traditional, complementary, and alternative medicines : AJTCAM
18.PMID: 26305373 (2015) — De Novo Transcriptome Analysis of Warburgia ugandensis to Identify Genes Involved in Terpenoids and Unsaturated Fatty Acids Biosynthesis. · PloS one
19.PMID: 33935707 (2021) — A Review of the Toxicity and Phytochemistry of Medicinal Plant Species Used by Herbalists in Treating People Living With HIV/AIDS in Uganda. · Frontiers in pharmacology
20.PMID: 35586188 (2022) — Cytotoxicity of Medicinal Plant Species Used by Traditional Healers in Treating People Suffering From HIV/AIDS in Uganda. · Frontiers in toxicology
21.PMID: 35406911 (2022) — An Annotated Inventory of Tanzanian Medicinal Plants Traditionally Used for the Treatment of Respiratory Bacterial Infections. · Plants (Basel, Switzerland)
22.PMID: 34679694 (2021) — Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G0/G1 Cell Cycle Arrest and Antiproliferation in A549 Cells. · Antioxidants (Basel, Switzerland)
23.PMID: 16732527 (2006) — In vitro 12(S)-HETE and leukotriene metabolism inhibitory activity of sesquiterpenes of Warburgia ugandensis. · Planta medica
24.PMID: 12789127 (2001) — Bioassay-guided studies on the cytotoxic and in vitro trypanocidal activities of a sesquiterpene (Muzigadial) derived from a Ugandan medicinal plant (Warburgia ugandensis). · African health sciences
25.PMID: 12789108 (2002) — Screening extracts of Zanthoxylum chalybeum and Warburgia ugandensis for activity against measles virus (Swartz and Edmonston strains) in vitro. · African health sciences
26.PMID: 20435133 (2010) — Prophylactic and curative activities of extracts from Warburgia ugandensis Sprague (Canellaceae) and Zanthoxylum usambarense (Engl.) Kokwaro (Rutaceae) against Plasmodium knowlesi and Plasmodium berghei. · Journal of ethnopharmacology
27.PMID: 37600549 (2023) — Medicinal Plants Used in the Management of Sexual Dysfunction, Infertility and Improving Virility in the East African Community: A Systematic Review. · Evidence-based complementary and alternative medicine : eCAM
28.PMID: 3286823 (1988) — Polygodial, an antifungal potentiator. · Journal of natural products
29.PMID: 41917904 (2026) — In vitro evaluation of the antibacterial, antioxidant, and phytochemical investigation of Clematis simensis Fresen and Warburgia ugandensis Sprague in Ochollo, South Ethiopia. · BMC complementary medicine and therapies