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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Warburgia ugandensis, also known as the East African greenheart or pepper bark tree, is a medicinal plant native to Africa with documented antimicrobial, anti-inflammatory, and antileishmanial properties [PMID:31848891, PMID:21461155].
Contexte
Warburgia ugandensis (Family: Canellaceae) is a medicinal tree widely distributed across Eastern, Central, and Southern Africa [PMID:31676401, PMID:25698247].
Usages traditionnels
Traditionally used in African countries to treat pneumonia, asthma, malaria, candidiasis, skin infections, HIV-opportunistic infections, diarrhea, measles, respiratory infections, tooth aches, venereal diseases, fevers, and aches [PMID:31848891, PMID:31676401]. It is also used in the management of sexual dysfunction, infertility, and to improve virility in the East African Community [PMID:37600549].
Composés actifs
The plant contains abundant terpenoids, including drimane and coloratane type sesquiterpenoids (such as ugandensial, warburganal, mukaadial, and polygodial) [PMID:31848891, PMID:30031002]. Other secondary metabolites include tannins, flavonoids (specifically flavonol glycosides like kaempferol and quercetin), saponins, steroids, mannitol, and lignanamides [PMID:31848891, PMID:14559287, PMID:33804549].
Mécanisme d'action
Certain sesquiterpenes (ugandensidial and muzigadial) inhibit 12-LOX and 5-LOX enzymes, reducing the biosynthesis of 12(S)-HETE and leukotriene B4 [PMID:16732527]. Polygodial acts by damaging the cell membrane of fungi, potentially facilitating the transmembrane transport of other chemicals [PMID:3286823]. In A549 lung cancer cells, dimethyl carbonate extracts induce ROS generation leading to G0/G1 cell cycle arrest [PMID:34679694].
Preuves cliniques
Preuve DLeishmaniasis (L. major)
Oral administration of extracts reduced lesion size in BALB/c mice; intraperitoneal injection also showed healing by day 42 [PMID:20209014]. Extracts demonstrated in vitro antileishmanial activity with an IC50 of 1.114 mg/ml [PMID:21461155].
Preuve DMalaria (Plasmodium knowlesi and P. berghei)
Extracts showed in vitro anti-plasmodial activity (IC50 3.14 to 75 microg/ml) and provided over 80% survivorship in treated BALB/c mice [PMID:20435133].
Preuve DFungal and Bacterial Infections
Extracts exhibit strong antimicrobial activity against a broad spectrum of pathogens, including biofilm-inhibiting properties against Candida and staphylococci [PMID:31848891, PMID:31676401].
Preuve DHelminthiasis
Purified compounds warburganal and polygodial demonstrated anthelmintic activity against C. elegans [PMID:30031002].
Preuve DNon-small cell lung cancer (A549 cells)
Dimethyl carbonate extract inhibited proliferation in a time- and dose-dependent manner via ROS generation and G0/G1 arrest [PMID:34679694].
Sécurité et effets indésirables
Cytotoxicity studies using the human glioblastoma cell line U87.CD4.CXCR4 were conducted to determine the CC50 of extracts used by PLHIV in Uganda [PMID:35586188].
Synthèse des preuves
The current evidence consists primarily of in vitro studies, animal models (mice), and literature reviews. There are no randomized controlled trials (RCTs) or human clinical trials provided in the source abstracts.
Sources PubMed
1.PMID: 37895122 (2023) — Plant Extracts as Skin Care and Therapeutic Agents. · International journal of molecular sciences
2.PMID: 31848891 (2021) — Ethnopharmacological Potentials of Warburgia ugandensis on Antimicrobial Activities. · Chinese journal of integrative medicine
3.PMID: 24188508 (2014) — The genus Warburgia: a review of its traditional uses and pharmacology. · Pharmaceutical biology
4.PMID: 25698247 (2015) — Warburgia: a comprehensive review of the botany, traditional uses and phytochemistry. · Journal of ethnopharmacology
5.PMID: 24624248 (2014) — Immunostimulatory responses to crude extracts of Warburgia ugandensis (Sprague) subsp ugandensis (Canellaceae) by BALB/c mice infected with Leishmania major.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 12789119 (2001) — Antibacterial and antifungal activities of extracts of Zanthoxylum chalybeum and Warburgia ugandensis, Ugandan medicinal plants. · African health sciences
7.PMID: 31676401 (2020) — Biofilm inhibiting properties of compounds from the leaves of Warburgia ugandensis Sprague subsp ugandensis against Candida and staphylococcal biofilms. · Journal of ethnopharmacology
8.PMID: 33915848 (2021) — Identification of Anti-Inflammatory and Anti-Proliferative Neolignanamides from Warburgia ugandensis Employing Multi-Target Affinity Ultrafiltration and LC-MS. · Pharmaceuticals (Basel, Switzerland)
9.PMID: 38816414 (2024) — The chromosome-level genomes of the herbal magnoliids Warburgia ugandensis and Saururus chinensis. · Scientific data
10.PMID: 30031002 (2018) — Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial. · International journal for parasitology
11.PMID: 21461155 (2010) — In vitro effects of Warburgia ugandensis, Psiadia punctulata and Chasmanthera dependens on Leishmania major promastigotes. · African journal of traditional, complementary, and alternative medicines : AJTCAM
13.PMID: 33804549 (2021) — New Lignanamides with Antioxidant and Anti-Inflammatory Activities Screened Out and Identified from Warburgia ugandensis Combining Affinity Ultrafiltration LC-MS with SOD and XOD Enzymes. · Antioxidants (Basel, Switzerland)
14.PMID: 34961234 (2021) — Warburgia ugandensis Leaf and Bark Extracts: An Alternative to Copper as Fungicide against Downy Mildew in Organic Viticulture? · Plants (Basel, Switzerland)
16.PMID: 16153670 (2005) — Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity. · Phytochemistry
17.PMID: 20209014 (2009) — In vivo efficacy of oral and intraperitoneal administration of extracts of Warburgia ugandensis (Canellaceae) in experimental treatment of Old World cutaneous leishmaniasis caused by Leishmania major. · African journal of traditional, complementary, and alternative medicines : AJTCAM
18.PMID: 26305373 (2015) — De Novo Transcriptome Analysis of Warburgia ugandensis to Identify Genes Involved in Terpenoids and Unsaturated Fatty Acids Biosynthesis. · PloS one
19.PMID: 33935707 (2021) — A Review of the Toxicity and Phytochemistry of Medicinal Plant Species Used by Herbalists in Treating People Living With HIV/AIDS in Uganda. · Frontiers in pharmacology
20.PMID: 35586188 (2022) — Cytotoxicity of Medicinal Plant Species Used by Traditional Healers in Treating People Suffering From HIV/AIDS in Uganda. · Frontiers in toxicology
21.PMID: 35406911 (2022) — An Annotated Inventory of Tanzanian Medicinal Plants Traditionally Used for the Treatment of Respiratory Bacterial Infections. · Plants (Basel, Switzerland)
22.PMID: 34679694 (2021) — Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G0/G1 Cell Cycle Arrest and Antiproliferation in A549 Cells. · Antioxidants (Basel, Switzerland)
23.PMID: 16732527 (2006) — In vitro 12(S)-HETE and leukotriene metabolism inhibitory activity of sesquiterpenes of Warburgia ugandensis. · Planta medica
24.PMID: 12789127 (2001) — Bioassay-guided studies on the cytotoxic and in vitro trypanocidal activities of a sesquiterpene (Muzigadial) derived from a Ugandan medicinal plant (Warburgia ugandensis). · African health sciences
25.PMID: 12789108 (2002) — Screening extracts of Zanthoxylum chalybeum and Warburgia ugandensis for activity against measles virus (Swartz and Edmonston strains) in vitro. · African health sciences
26.PMID: 20435133 (2010) — Prophylactic and curative activities of extracts from Warburgia ugandensis Sprague (Canellaceae) and Zanthoxylum usambarense (Engl.) Kokwaro (Rutaceae) against Plasmodium knowlesi and Plasmodium berghei. · Journal of ethnopharmacology
27.PMID: 37600549 (2023) — Medicinal Plants Used in the Management of Sexual Dysfunction, Infertility and Improving Virility in the East African Community: A Systematic Review. · Evidence-based complementary and alternative medicine : eCAM
28.PMID: 3286823 (1988) — Polygodial, an antifungal potentiator. · Journal of natural products
29.PMID: 41917904 (2026) — In vitro evaluation of the antibacterial, antioxidant, and phytochemical investigation of Clematis simensis Fresen and Warburgia ugandensis Sprague in Ochollo, South Ethiopia. · BMC complementary medicine and therapies