Fiche d'information compilée à partir de PubMed
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Compilé à partir de 3 articles PubMed · modèle : gemma4:31b
Résumé
Xanthorrhiza simplicissima, commonly known as yellowroot, is a deciduous shrub native to the eastern hardwood forests of the United States containing bioactive compounds including berberine [PMID:27671811, PMID:40857125].
Contexte
Xanthorhiza simplicissima (yellowroot) is a deciduous shrub that typically reaches one to three feet in height and thrives in wet, shady settings within the eastern hardwood forests of the United States [PMID:40857125].
Usages traditionnels
The roots have been used extensively in Native American medicine, specifically by the Cherokee people, as a tonic and for the treatment of jaundice, cramps, and ulcers [PMID:40857125].
Composés actifs
Yellowroot extracts contain alkaloids (specifically berberine), triterpenes, phenolics, flavonoids, and sterols [PMID:27671811, PMID:40857125].
Mécanisme d'action
Berberine, a compound found in Xanthorhiza simplicissima, exerts significant antioxidant and anti-inflammatory activities in vitro [PMID:27671811].
Preuves cliniques
Preuve BLipid levels and insulin resistance
Berberine (found in yellowroot) has demonstrated lipid-lowering and insulin-resistance improving actions in numerous randomized clinical trials [PMID:27671811].
Preuve BEndothelial inflammation
Preliminary clinical evidence suggests berberine can reduce endothelial inflammation to improve vascular health, including in patients with cardiovascular disease [PMID:27671811].
Synthèse des preuves
Evidence for the herb itself is primarily based on reviews of its phytochemistry and traditional use; however, there is strong clinical evidence (RCTs) for the efficacy of its constituent compound, berberine, regarding metabolic and vascular health.
Sources PubMed
- 1.PMID: 27671811 (2016) — Berberine and Its Role in Chronic Disease. · Advances in experimental medicine and biology
- 2.PMID: 40857125 (2025) — A mini review on marshal (yellowroot): phytochemistry and ethnobotanical significance. · Natural product research