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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Yin Chen Hao (Artemisia capillaris) works primarily through its choleretic action, stimulating bile production and flow from the liver. Active compounds including scoparone, chlorogenic acid, and capillin have demonstrated hepatoprotective and anti-inflammatory properties in laboratory studies. These constituents help reduce bilirubin levels by enhancing liver function and promoting bile excretion. Traditional Chinese Medicine describes this mechanism as clearing damp-heat from the liver and gallbladder channels. Evidence level: C (preliminary clinical evidence and traditional use).
Does Yin Chen Hao interact with any medications?
Limited formal drug interaction studies exist for Yin Chen Hao. Due to its effects on liver function and bile secretion, it may theoretically alter the metabolism of hepatically-processed medications, including certain statins, anticoagulants, and immunosuppressants. Patients taking hepatotoxic medications should exercise caution. Always consult a qualified healthcare provider before combining Yin Chen Hao with prescription medications. Evidence level: C (theoretical interactions based on pharmacological properties).
What is the recommended dosage of Yin Chen Hao for adults?
The standard adult dosage for Yin Chen Hao (Artemisia capillaris) is 10-30 grams daily when prepared as a decoction. The herb is typically boiled in water for 20-30 minutes to extract the active compounds. Lower doses of 10-15 grams are common for mild conditions, while higher doses of 20-30 grams may be used for acute jaundice or hepatitis under professional supervision. Always follow guidance from a qualified TCM practitioner. Evidence level: Traditional.
Is Yin Chen Hao safe to take during pregnancy?
Traditional Chinese Medicine sources classify Yin Chen Hao as generally safe during pregnancy when used appropriately for its indicated conditions. However, pregnant women should only use this herb under the supervision of a qualified TCM practitioner who can assess whether it suits their specific presentation. The herb's cooling and draining properties require careful matching to the patient's constitution. Self-medication during pregnancy is not recommended. Evidence level: Traditional use.
What is Yin Chen Hao used for in Traditional Chinese Medicine?
Yin Chen Hao is considered the premier TCM herb for treating jaundice and liver-gallbladder disorders. Primary indications include infectious hepatitis, cholecystitis (gallbladder inflammation), and various forms of jaundice characterized by yellow discoloration of skin and eyes. It specifically treats damp-heat conditions affecting the liver and gallbladder channels. The herb is contraindicated in cold-deficiency jaundice, where warming herbs would be more appropriate. Evidence level: C.
What are the side effects of Yin Chen Hao?
Yin Chen Hao is generally well-tolerated at recommended doses. The most commonly reported side effects are mild digestive disturbances, including nausea, bloating, or loose stools, particularly when taken on an empty stomach or at higher doses. These effects typically resolve by taking the decoction with food or reducing dosage. Allergic reactions are rare but possible in individuals sensitive to plants in the Asteraceae family. Evidence level: Traditional.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Yin Chen Hao (Artemisia capillaris) is a traditional medicinal herb primarily used for treating liver dysfunction, cholestasis, and jaundice [PMID:32877694, PMID:34680529].
Contexte
Artemisia capillaris Thunb., also known as Yin Chen Hao or capillary wormwood, is a plant in the Asteraceae family used extensively in traditional Chinese medicine [PMID:39515682, PMID:34680529].
Usages traditionnels
It is traditionally used to clear dampness and heat, promote gallbladder function, reduce jaundice, and treat hepatic disorders [PMID:39515682, PMID:24716150, PMID:39067315]. It has also been used in the treatment of neonatal jaundice [PMID:9104069].
Composés actifs
Bioactive compounds include scoparone (6,7-dimethoxycoumarin), chlorogenic acid, capillarisin, scopoletin, rhein, geniposide, and emodin [PMID:34680529, PMID:28275293].
Mécanisme d'action
Pharmacological actions include antioxidant, anti-inflammatory, antisteatotic, antiviral, and antitumor properties [PMID:34680529]. Specific mechanisms include the inhibition of hepatic steatosis, apoptosis, and necrosis [PMID:28275293], regulation of the YAP/TAZ-signaling pathway in MASH [PMID:40683423], inhibition of miR-34a-5p to activate Sirt1-mediated hepatic lipid metabolism [PMID:39515682], and modulation of the FXR-FGF15 pathway via gut microbiota regulation [PMID:40732223]. Scoparone specifically affects immune cells and signaling pathways such as TLR4/Myd88/NF-κB and mTOR suppression [PMID:39958341, PMID:40490231].
Preuves cliniques
Preuve CChronic Hepatitis B
Demonstrates therapeutic advantages through modulation of immune pathways and intervention in HBV lifecycle targets [PMID:40708494]
Preuve CCholestatic Liver Disease/Hepatitis
Yinchenhao decoction (YCHD) is used to treat cholestasis and mitigate cholestatic liver injury [PMID:38583348, PMID:40732223]
Water extract alleviates MASLD by inhibiting miR-34a-5p [PMID:39515682]; Injinoryeong-san (containing A. capillaris) attenuates MASH via YAP/TAZ-signaling [PMID:40683423]
Preuve DBiliary Obstructive Cirrhosis
Yin-Chen-Hao-Tang (YCHT) alleviates biliary obstructive cirrhosis in rats by inhibiting biliary epithelial cell proliferation and activation [PMID:25829784]
Preuve DRenal Injury
Water extract attenuates adriamycin-induced renal injury by regulating apoptosis through the ROS/MAPK axis [PMID:34984698]
Preuve D
Sécurité et effets indésirables
While used for liver protection, some reports indicate a risk of liver injury associated with other ingredients in Yinchenhao decoction, such as Rheum palmatum L. and Gardenia jasmonoides [PMID:38583348]. Additionally, some traditional Chinese medicine injections may cause pseudo-allergic reactions [PMID:39067315].
Synthèse des preuves
The evidence consists primarily of review articles (Level C) and preclinical animal or in vitro studies (Level D). There is strong preclinical evidence for hepatoprotective and anti-inflammatory effects, but high-level clinical trial data (Level A/B) is not provided in the abstracts.
Sources PubMed
1.PMID: 28275293 (2017) — Therapeutic mechanism of Yīn-Chén-Hāo decoction in hepatic diseases. · World journal of gastroenterology
2.PMID: 40708494 (2025) — The Role of Chinese Medicine in the Treatment of Chronic Hepatitis B. · The American journal of Chinese medicine
3.PMID: 40553824 (2025) — Investigating therapeutic effects and the underlying mechanisms of jia-wei-yin-chen-hao-tang in non-alcoholic fatty liver disease based on network pharmacology analysis and experimental validation. · Journal of ethnopharmacology
4.PMID: 24716150 (2013) — Recent Studies and Progression of Yin Chen Hao ( Yīn Chén Hāo), a Long-term Used Traditional Chinese Medicine. · Journal of traditional and complementary medicine
5.PMID: 34680529 (2021) — The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
YCHD inhibits growth and induces apoptosis of PANC-1 cells via up-regulation of BAX and down-regulation of BCL-2 [PMID:26217086]
· Biomedicines
6.PMID: 26357619 (2014) — Traditional Chinese Medicine Induced Liver Injury. · Journal of clinical and translational hepatology
7.PMID: 38583348 (2024) — Optimized therapeutic potential of Yinchenhao decoction for cholestatic hepatitis by combined network meta-analysis and network pharmacology. · Phytomedicine : international journal of phytotherapy and phytopharmacology
8.PMID: 39958341 (2025) — The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases. · Frontiers in immunology
9.PMID: 25829784 (2015) — Yin-Chen-Hao-Tang alleviates biliary obstructive cirrhosis in rats by inhibiting biliary epithelial cell proliferation and activation. · Pharmacognosy magazine
10.PMID: 24177191 (2014) — Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis. · Fitoterapia
11.PMID: 40683423 (2025) — Injinoryeong-San attenuates metabolic dysfunction-associated steatohepatitis via regulation of YAP/TAZ-signaling pathway. · Journal of ethnopharmacology
12.PMID: 40490231 (2025) — Scoparone alleviates aortic aneurysm formation by inhibiting smooth muscle cell phenotypic switching and inflammation via mTOR suppression. · Journal of ethnopharmacology
13.PMID: 39515682 (2025) — Artemisia capillaris Thunb. Water extract alleviates metabolic dysfunction-associated Steatotic liver disease Disease by inhibiting miR-34a-5p to activate Sirt1-mediated hepatic lipid metabolism. · Journal of ethnopharmacology
14.PMID: 17430643 (2007) — Yin-Chen-Hao-Tang ameliorates obstruction-induced hepatic apoptosis in rats. · The Journal of pharmacy and pharmacology
15.PMID: 32956722 (2020) — Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines. · Pharmacology & therapeutics
16.PMID: 9104069 (1996) — Traditional Chinese medicine and treatment of neonatal jaundice. · Singapore medical journal
17.PMID: 40732223 (2025) — Yinchenhao Decoction Mitigates Cholestatic Liver Injury in Mice via Gut Microbiota Regulation and Activation of FXR-FGF15 Pathway. · Pharmaceuticals (Basel, Switzerland)
18.PMID: 34984698 (2022) — Artemisia capillaris Thunb. water extract attenuates adriamycin-induced renal injury by regulating apoptosis through the ROS/MAPK axis. · Journal of food biochemistry
19.PMID: 26805802 (2016) — Serum Metabolomic Characterization of Liver Fibrosis in Rats and Anti-Fibrotic Effects of Yin-Chen-Hao-Tang. · Molecules (Basel, Switzerland)
20.PMID: 27790147 (2016) — Yin-Chen-Hao Tang Attenuates Severe Acute Pancreatitis in Rat: An Experimental Verification of In silico Network Target Prediction. · Frontiers in pharmacology
21.PMID: 26217086 (2015) — Apoptosis of human pancreatic carcinoma cell-1 cells induced by Yin Chen Hao Decoction. · World journal of gastroenterology
22.PMID: 35766471 (2022) — Artemisia capillaris nucleorhabdovirus 1, a novel member of the genus Alphanucleorhabdovirus, identified in the Artemisia capillaris transcriptome. · Acta virologica
23.PMID: 35954035 (2022) — Optimization of Fermentation Conditions of Artemisia capillaris for Enhanced Acetylcholinesterase and Butyrylcholinesterase. · Foods (Basel, Switzerland)
24.PMID: 35863612 (2022) — Promising traditional Chinese medicine for the treatment of cholestatic liver disease process (cholestasis, hepatitis, liver fibrosis, liver cirrhosis). · Journal of ethnopharmacology
25.PMID: 32877694 (2020) — Scoparone as a therapeutic drug in liver diseases: Pharmacology, pharmacokinetics and molecular mechanisms of action. · Pharmacological research
27.PMID: 26366183 (2015) — A Survey of Therapeutic Effects of Artemisia capillaris in Liver Diseases. · Evidence-based complementary and alternative medicine : eCAM
28.PMID: 31261038 (2019) — Determining the protective effects of Yin-Chen-Hao Tang against acute liver injury induced by carbon tetrachloride using 16S rRNA gene sequencing and LC/MS-based metabolomics. · Journal of pharmaceutical and biomedical analysis
30.PMID: 39067315 (2024) — MrgX2-targeted ligand screening from Artemisia capillaris Thunb. extract and receptor-ligand interaction analysis based on MrgX2-HALO-tag/CMC. · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences