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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Gleditsia sinensis (Zao Jiao) is a multifaceted plant with significant medicinal, edible, and economic value [PMID:38734341, PMID:38383559].
Contexte
Gleditsia sinensis Lam., also known as the Chinese Honey locust, is a native deciduous tree in China [PMID:38734341, PMID:26909943].
Usages traditionnels
Traditionally used in East Asian countries for the treatment of measles, indigestion, whooping cough, smallpox, arthrolithiasis, constipation, diarrhea, hematochezia, dysentery, and carbuncles [PMID:26643065]. The seeds (Zaojiaozi) are specifically used for intestinal wind, hematochezia, dysentery, and tenesmus [PMID:42219067]. The thorns (Zao Jiao Ci) are traditionally used to reduce inflammation [PMID:27401288].
Composés actifs
The plant contains triterpenes, sterols, flavonoids, alkaloids, and phenolics [PMID:26643065]. Specific components include galactomannans from seeds [PMID:27999373], triterpenoidal saponins (gleditsiosides H-K and gleditsia saponins C' and E') from anomalous fruits [PMID:10570830], and a new flavonoid, (2'''E,6'''S)-4''-(6-hydroxy-2,6-dimethylocta-2,7-dienoyl)-vitexin, isolated from the thorns [PMID:34448432].
Mécanisme d'action
Anti-inflammatory effects are mediated by the suppression of the STAT3/STAT6 pathway in nasal inflammation [PMID:36921533] and the reduction of cyclooxygenase (COX)-2 expression, PGE2, and tumor necrosis factor [PMID:27401288]. Other mechanisms include the modulation of the TLR4/NF-κB/NLRP3 signaling pathway for ulcerative colitis [PMID:42219067] and the TLR4/MyD88/NF-κB pathway for type 2 diabetes [PMID:42188048], as well as the suppression of JAK2-STAT3 and NF-κB signaling pathways in colitis [PMID:42173610].
Preuves cliniques
Preuve DInflammation (Paw Edema)
Aqueous extract of Zao-Jiao-Ci (ZJC) showed a significant suppressive effect on carrageenan-induced paw edema in rats at 100mg/kg [PMID:27401288]
Preuve DAllergic Rhinitis
Aqueous extract attenuated nasal inflammation in OVA-induced mouse models by inhibiting MUC5AC production [PMID:36921533]
Preuve DUlcerative Colitis
Processed perisperm (Zaojiao Mi) and mannan oligosaccharides (G-MOS) mitigated colitis symptoms and preserved colonic epithelial barrier integrity in mice [PMID:42219067, PMID:42173610]
Preuve DType 2 Diabetes Mellitus
Zaojiaomi polysaccharide (ZJMP) significantly ameliorated hyperglycemia and associated cardiorenal injuries in HFD/STZ-induced rat models [PMID:42188048]
Preuve DOvarian Cancer (SKOV-3 cells)
Certain compounds isolated from thorns showed cytotoxic effects with IC50 values ranging from 15.38 to 80.13 μM [PMID:32290704]
Sécurité et effets indésirables
In vivo safety assessment of the processed perisperm product Zaojiao Mi (ZJM) was conducted, though specific adverse effects were not detailed in the provided abstract [PMID:42219067].
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating anti-inflammatory, antidiabetic, and cytotoxic activities. No human clinical trials were provided.
Sources PubMed
1.PMID: 38734341 (2024) — Analysis of differential mRNA and miRNA expression induced by heterogeneous grafting in Gleditsia sinensis. · International journal of biological macromolecules
2.PMID: 38383559 (2024) — Characterization of the chloroplast genome of Gleditsia species and comparative analysis. · Scientific reports
3.PMID: 27401288 (2016) — In vivo and in vitro anti-inflammatory effects of Zao-Jiao-Ci (the spine of Gleditsia sinensis Lam.) aqueous extract and its mechanisms of action. · Journal of ethnopharmacology
4.PMID: 38066414 (2023) — Full-length transcriptome characterization and comparative analysis of Gleditsia sinensis. · BMC genomics
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— A new flavonoid from the thorn of Gleditsia sinensis Lam.
· Natural product research
6.PMID: 34828937 (2021) — The Garbage Enzyme with Chinese Hoenylocust Fruits Showed Better Properties and Application than When Using the Garbage Enzyme Alone. · Foods (Basel, Switzerland)
7.PMID: 27999373 (2016) — Characterization of Fractional Polysaccharides from Gleditsia sinensis and Gleditsia microphylla Gums. · Molecules (Basel, Switzerland)
8.PMID: 39738241 (2024) — Screening and identification of evaluation indicators of low phosphorus tolerant germplasm in Gleditsia sinensis Lam. · Scientific reports
9.PMID: 38699588 (2024) — Metabolite components and nutritional composition of the endosperm in seven species from Gleditsia. · Food chemistry: X
10.PMID: 26643065 (2016) — Gleditsia species: An ethnomedical, phytochemical and pharmacological review. · Journal of ethnopharmacology
11.PMID: 37050082 (2023) — Comparative Transcriptome Analysis of Gleditsia sinensis Thorns at Different Stages of Development. · Plants (Basel, Switzerland)
12.PMID: 42219067 (2026) — Gleditsia sinensis perisperm ameliorates DSS-induced ulcerative colitis via the TLR4/NF-κB/NLRP3 signaling pathway: Safety evaluation and bioactive amino acid profiling. · Journal of ethnopharmacology
13.PMID: 42188048 (2026) — Polysaccharide from Gleditsia sinensis Seed Endosperm Ameliorates Type 2 Diabetes and Its Associated Cardiorenal Injuries by Modulating TLR4/MyD88/NF-κB Pathway and Gut Microbiota. · Metabolites
14.PMID: 26909943 (2016) — De novo assembly and characterization of Gleditsia sinensis transcriptome and subsequent gene identification and SSR mining. · Genetics and molecular research : GMR
15.PMID: 39265908 (2024) — New insight into synergistic interaction between the backbone or side chain of xanthan gum and the backbone of Gleditsia sinensis polysaccharide. · International journal of biological macromolecules
16.PMID: 42173610 (2026) — Structure-dependent effects of yeast- and Gleditsia-derived mannan oligosaccharides on dextran sodium sulfate-induced colitis in mice. · Carbohydrate polymers
17.PMID: 42192307 (2026) — Analysis of trait differences and identification of superior early growth combinations in interspecific hybrid progenies of Gleditsia sinensis. · BMC plant biology
18.PMID: 36610566 (2023) — Enzymatically mediated Gleditsia sinensis galactomannan based hydrogel inspired by wound healing process. · International journal of biological macromolecules
19.PMID: 42062782 (2026) — Chemical Pattern Recognition and Quality Assessment of Gleditsia sinensis Gum Utilizing Fingerprint Spectroscopy and Quantitative Analysis. · Biomedical chromatography : BMC
20.PMID: 28515651 (2017) — Effect of Gleditsia sinensis Lam. Extract on Physico-Chemical Properties of Emulsion-Type Pork Sausages. · Korean journal for food science of animal resources
21.PMID: 27433183 (2016) — From Traditional Usage to Pharmacological Evidence: A Systematic Mini-Review of Spina Gleditsiae. · Evidence-based complementary and alternative medicine : eCAM
23.PMID: 36921533 (2023) — Gleditsia sinensis Lam. aqueous extract attenuates nasal inflammation in allergic rhinitis by inhibiting MUC5AC production through suppression of the STAT3/STAT6 pathway. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
24.PMID: 37968307 (2023) — Physiological response and drought resistance evaluation of Gleditsia sinensis seedlings under drought-rehydration state. · Scientific reports
25.PMID: 32290704 (2020) — Chemical constituents from the thorns of Gleditsia sinensis and their cytotoxic activities. · Journal of Asian natural products research
26.PMID: 39293243 (2024) — Effects of ultrasonic degradation on physicochemical and antioxidant properties of Gleditsia sinensis seed polysaccharides. · Carbohydrate research
27.PMID: 40772057 (2025) — Transcriptomic reveals key genes and regulatory pathways in galactomannan biosynthesis in Gleditsia sinensis polysaccharide gum. · Frontiers in plant science
28.PMID: 34214797 (2021) — Effects of Gleditsia sinensis pod powder, coconut shell biochar and rice husk biochar as additives on bacterial communities and compost quality during vermicomposting of pig manure and wheat straw. · Journal of environmental management
29.PMID: 38481144 (2024) — Transcriptome analysis reveals regulatory mechanisms of different drought-tolerant Gleditsia sinensis seedlings under drought stress. · BMC genomic data