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Compiled from 14 PubMed articles · model: gemma4:31b
Summary
Achillea ligustica is a medicinal species of the Asteraceae family characterized by a chemically diverse essential oil and high polyphenol content [PMID:39274964, PMID:35448782]. It has demonstrated antioxidant, antimicrobial, and analgesic properties in various studies [PMID:38300819].
Background
Achillea ligustica is a medicinal plant in the Asteraceae family found in various Mediterranean locations, including mainland Italy, the Aeolian Islands, Sardinia, and Corsica [PMID:39274964, PMID:35448782, PMID:16366708, PMID:16910724].
Traditional uses
In Southern Italy, it is used against psoriasis and other skin diseases [PMID:25278440].
Active compounds
The plant contains a wide array of secondary metabolites. Essential oils include monoterpenes such as $\beta$-pinene, borneol, $\alpha$-terpineol, isobornyl acetate, 1,8-cineole, camphor, and santolina alcohol [PMID:35448782, PMID:16910724, PMID:16366708]. Polyphenolic compounds identified in hydroethanol extracts include caffeoyl-6-oleside, eucommin A, quercetin-3-O-$\beta$-D-glucoside, and cirsimaritin [PMID:38300819]. Other identified constituents include flavonoids like luteolin, apigenin, and apigenin-7-O-glucuronide, as well as triterpenes such as moretenol [PMID:19570644, PMID:26327332, PMID:16141563].
Mechanism of action
Methanol crude extracts inhibit 5-LOX and COX-1 activities and prevent NF$\kappa$B activation, while increasing the biosynthesis of the anti-inflammatory eicosanoid 15(S)-HETE [PMID:25278440].
Clinical evidence
Evidence DPain (Central and Peripheral)
The hydroethanol extract showed a significant dose-dependent capacity to reduce pain in in vivo assays (tail flick, hot plate, and acetic acid tests) [PMID:38300819].
Evidence DOral Microorganisms/Cariogenic Bacteria
Essential oils show strong inhibitory activity against Streptococcus mutans, Bacillus cereus, Streptococcus pyogenes, and Candida albicans [PMID:22253099, PMID:19379797, PMID:25911964].
Evidence DOxidative Stress
Extracts demonstrate antioxidant potential in DPPH, ABTS, and phenanthroline tests [PMID:38300819, PMID:19570644, PMID:16141563].
Safety & adverse effects
In acute toxicity tests, no deaths were observed at doses of 100, 750, and 1500 mg/Kg, with an LD50 higher than 2000 mg/Kg [PMID:38300819].
Evidence summary
The current evidence is primarily based on in vitro and in vivo animal studies (Level D), demonstrating significant pharmacological potential in antimicrobial, antioxidant, and analgesic activities, but lacks human clinical trial data.
PubMed sources
1.PMID: 35448782 (2022) — Essential Oil Biodiversity of Achillea ligustica All. Obtained from Mainland and Island Populations. · Plants (Basel, Switzerland)
2.PMID: 38300819 (2025) — RP-UHPLC-ESI-QTOF-MSn analyses, antioxidant, antimicrobial, analgesic activities and toxicity of Achillea ligustica All. · Natural product research
3.PMID: 39274964 (2024) — Phenolic Constituents, Photoprotective Effect, and Antioxidant Capacities of Achillea ligustica All. · Molecules (Basel, Switzerland)
4.PMID: 25911964 (2015) — Antibacterial Activity of Essential Oils and Their Isolated Constituents against Cariogenic Bacteria: A Systematic Review. · Molecules (Basel, Switzerland)
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Ethnobotanical and phytomedical knowledge in the North-Western Ligurian Alps.
· Journal of ethnopharmacology
6.PMID: 26327332 (2016) — Phytochemical analysis of Achillea ligustica All. from Lipari Island (Aeolian Islands). · Natural product research
7.PMID: 22253099 (2012) — Antimicrobial efficacy of Achillea ligustica All. (Asteraceae) essential oils against reference and isolated oral microorganisms. · Chemistry & biodiversity
8.PMID: 25278440 (2015) — Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases. · Phytotherapy research : PTR
9.PMID: 19570644 (2009) — Flavonoid characterization and antioxidant activity of hydroalcoholic extracts from Achillea ligustica All. · Journal of pharmaceutical and biomedical analysis
10.PMID: 16141563 (2005) — Comparative radical scavenging and antidiabetic activities of methanolic extract and fractions from Achillea ligustica ALL. · Biological & pharmaceutical bulletin
11.PMID: 16910724 (2006) — Composition, enantiomeric distribution, and antibacterial activity of the essential oil of Achillea ligustica All. from Corsica. · Journal of agricultural and food chemistry
12.PMID: 19379797 (2009) — Composition and biological activity of essential oil of Achillea ligustica All. (Asteraceae) naturalized in central Italy: ideal candidate for anti-cariogenic formulations. · Fitoterapia
13.PMID: 16366708 (2005) — Chemical composition and antioxidant, antimicrobial, and antifungal activities of the essential oil of Achillea ligustica all. · Journal of agricultural and food chemistry
14.PMID: 24427958 (2013) — Chemical composition and free radical scavenging activity of the essential oil of Achillea ligustica growing wild in Lipari (Aeolian Islands, Sicily). · Natural product communications