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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Aerva lanata is a medicinal plant used in traditional systems like Ayurveda and Siddha for various therapeutic purposes, including the treatment of urolithiasis and respiratory issues [PMID:22279378, PMID:20979430].
Background
Aerva lanata (L.) Juss. ex Schult (family Amaranthaceae), locally known as 'bui', is an erect or prostrate undershrub with a long tap-root, found throughout India [PMID:22279378].
Traditional uses
Traditionally used for cough, sore throat, asthma [PMID:35143934], strangury, headache, and urolithiasis [PMID:22279378]. In Nigeria, it is used for lithiasis, renal disorder, haematemesis, bronchitis, nasal bleeding, scorpion stings, fractures, and spermatorrhoea [PMID:28668647]. It is also consumed as a tonic by pregnant women to relieve stomach pains and prevent miscarriage [PMID:37122890].
Active compounds
Phytochemical constituents include alkaloids (ervine, methylervine, ervoside, aervine, methylaervine, aervoside, ervolanine, and aervolanine), flavonoids (kaempferol, quercetin, isorhamnetin, persinol, persinosides A and B), methyl grevillate, lupeol, lupeol acetate, benzoic acid, β-sitosteryl acetate, and tannic acid [PMID:22279378]. Other identified components include ferulic acid and β-carboline [PMID:24681590], as well as various steroids [PMID:23569807] and phenolic acids [PMID:34201147].
Mechanism of action
In allergic asthmatic mice, the ethyl acetate extract lowered levels of inflammatory modulator TNF-α and IgE antibodies, and reduced interleukin 4, 5, and 13 [PMID:35143934]. In osteosarcoma cell lines (Saos2), it exerts an oncolytic effect via the apoptotic signaling pathway [PMID:38738026]. It also demonstrates the ability to inhibit diabetes-related enzymes α-amylase and α-glucosidase [PMID:30356437].
Clinical evidence
Evidence DUrolithiasis
Isolated compounds quercetin and betulin significantly increased urine volume in ethylene glycol-induced urolithiasis rat models [PMID:29169771].
Evidence DAllergic Asthma
Ethyl acetate extract ameliorated the count of inflammatory cells in blood and broncho-alveolar lavage fluid (BALF) in mice [PMID:35143934].
Evidence DType-II Diabetes
A partially purified alkaloid fraction from roots caused a significant reduction in serum glucose levels in rats [PMID:23527955].
Evidence DHepatotoxicity
Petroleum ether extractable fraction reversed histopathological changes and restored liver marker enzymes in CCl4-induced rat models [PMID:21783628].
Evidence DOsteosarcoma
Extract demonstrated a dose-dependent decrease in Saos2 cell proliferation [PMID:38738026].
Safety & adverse effects
In Ayurveda, Aerva lanata is not prescribed for long-term use due to beliefs that it may produce structural changes in the urinary tract leading to renal failure [PMID:23225960]. Sub-chronic toxicity tests in rats (40-1000mg/kg for 90 days) were conducted to evaluate its safety profile [PMID:28668647].
Pregnancy & lactation
Consumed as a tonic by pregnant women to relieve stomach pains and prevent miscarriage [PMID:37122890]; however, an experimental study in pregnant rats showed that high doses (1000 mg/kg) significantly reduced the number of pups per litter and indicated anti-fertility and anti-implantation activities [PMID:37122890].
Evidence summary
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant pharmacological potential in anti-inflammatory, anti-urolithiatic, and anti-diabetic activities, but lacks human clinical trial data.
PubMed sources
1.PMID: 35143934 (2022) — Immunomodulatory and anti-inflammatory effects of Aerva lanata in ovalbumin induced allergic asthmatic mice. · Journal of ethnopharmacology
2.PMID: 29169771 (2017) — Antiurolithiatic activity of natural constituents isolated from Aerva lanata. · Journal of Ayurveda and integrative medicine
3.PMID: 28460429 (2017) — Cardioprotective mechanisms of phytochemicals against doxorubicin-induced cardiotoxicity. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
4.PMID: 38738026 (2024) — The Oncolytic Effect of Aerva lanata on Osteosarcoma Cell Lines via the Apoptotic Signaling Pathway. · Cureus
5.PMID: 37122890 (2023) — Anti-fertility effect of Aerva lanata crude extract in male Dams offspring: An experimental study.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
· International journal of reproductive biomedicine
6.PMID: 34368407 (2021) — Potential drug leads for SARS-CoV2 from phytochemicals of Aerva lanata: a Machine Learning approach. · Virusdisease
7.PMID: 34201147 (2021) — Antioxidant, Anti-Inflammatory, and Anti-Diabetic Activity of Phenolic Acids Fractions Obtained from Aerva lanata (L.) Juss. · Molecules (Basel, Switzerland)
8.PMID: 22279378 (2011) — Aerva lanata: A review on phytochemistry and pharmacological aspects. · Pharmacognosy reviews
9.PMID: 23225960 (2012) — Aerva lanata (Polpala): Its effects on the structure and function of the urinary tract. · Pharmacognosy research
10.PMID: 21783628 (2005) — Effect of Aerva lanata against hepatotoxicity of carbon tetrachloride in rats. · Environmental toxicology and pharmacology
11.PMID: 20979430 (2011) — Immunomodulatory and antitumor activity of Aerva lanata ethanolic extract. · Immunopharmacology and immunotoxicology
12.PMID: 22557194 (2005) — COMPARISION OF DIURETIC ACTIVITY OF ETHANOLIC EXTRACT OF AERVA LANATA (Linn.) Juss. ex. Schult & AERVA TOMENTOSA Forsk. Family: AMARANTHACEAE. · Ancient science of life
13.PMID: 23569807 (2011) — Chromatographic finger print analysis of steroids in Aerva lanata L by HPTLC technique. · Asian Pacific journal of tropical biomedicine
14.PMID: 29576701 (2018) — Evaluation of Antioxidant, Antimicrobial, and Antiurolithiatic Potential of Different Solvent Extracts of Aerva lanata Linn Flowers. · Pharmacognosy magazine
15.PMID: 11864768 (2002) — Antimicrobial activity and cytotoxicity of Aerva lanata. · Fitoterapia
16.PMID: 24681590 (2014) — Reduction of hexavalent chromium using Aerva lanata L.: elucidation of reduction mechanism and identification of active principles. · Journal of hazardous materials
17.PMID: 23527955 (2013) — Antidiabetic activity of alkaloids of Aerva lanata roots on streptozotocin-nicotinamide induced type-II diabetes in rats. · Pharmaceutical biology
18.PMID: 24511712 (2013) — In vitro anti cancer activity of ethanol extract fractions of Aerva lanata L. · Pakistan journal of biological sciences : PJBS
19.PMID: 35930306 (2023) — Molecular dynamics and docking studies on potentially active natural phytochemicals for targeting SARS-CoV-2 main protease. · Journal of biomolecular structure & dynamics
20.PMID: 41267656 (2025) — Biosynthesis of Nickel Nanoparticles Using Aqueous Aerva lanata Extract and Their Utilization in Antimicrobial Activity. · Luminescence : the journal of biological and chemical luminescence
21.PMID: 35209048 (2022) — LC-ESI-MS/MS Polyphenolic Profile and In Vitro Study of Cosmetic Potential of Aerva lanata (L.) Juss. Herb Extracts. · Molecules (Basel, Switzerland)
22.PMID: 28668647 (2017) — Toxicological evaluation of the aqueous whole plant extract of Aerva lanata (l.) Juss. ex Schult (Amaranthaceae). · Journal of ethnopharmacology
23.PMID: 30356437 (2018) — Leaf Extracts of Aerva lanata Inhibit the Activities of Type 2 Diabetes-Related Enzymes and Possess Antioxidant Properties. · Oxidative medicine and cellular longevity