PubMed-compiled information sheet
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Compiled from 2 PubMed articles · model: gemma4:31b
Summary
Habb-e-asgandh, a polyherbal formulation containing Ashwagandha, has demonstrated anti-tumorigenic and anti-proliferative effects in multiple myeloma cell lines [PMID:38019228, PMID:36444574].
Background
Habb-e-asgandh is a Unani herbal drug formulation used as an adjuvant therapy in the treatment of multiple myeloma [PMID:38019228].
Mechanism of action
Habb-e-asgandh induces apoptosis through mitochondrial dysfunction and suppresses cell proliferation by reducing proliferating cell nuclear antigen (PCNA) activity in multiple myeloma cells [PMID:36444574]. It also exhibits multi-strategic cytotoxic effects and influences anti-inflammatory (TNF-alpha, IL6) and anti-angiogenic (VEGF, Ang-2) markers [PMID:38019228].
Clinical evidence
Evidence DMultiple Myeloma (U266 cells)
Habb-e-asgandh exhibits adjunctive antitumor efficacy and cytotoxic effects, either alone or in combination with lenalidomide [PMID:38019228].
Evidence DMultiple Myeloma (RPMI8226 cells)
Habb-e-asgandh suppresses cell proliferation and induces apoptosis via mitochondrial dysfunction; LD30 and LD50 doses were determined as 0.3mg/ml and 0.5mg/ml respectively [PMID:36444574].
Drug interactions
Habb-e-asgandh has been studied in combination with the standard drug lenalidomide to evaluate efficacy against drug relapse and resistance in myeloma cells [PMID:38019228, PMID:36444574].
Evidence summary
The current evidence is limited to in vitro experimental studies (cell lines) demonstrating anti-cancer properties of a specific polyherbal formulation; no human clinical trials are provided.
PubMed sources
- 1.PMID: 38019228 (2023) — A Polyherbal Ashwagandha Formulation Exhibits Adjunctive Antitumor Efficacy Against U266 Myeloma Cells by Multi-Strategic Cytotoxic Effects: An Experimental Approach. · Asian Pacific journal of cancer prevention : APJCP
- 2.PMID: 36444574 (2022) — Habb-e-Asgandh Suppresses Cell Proliferation and Induces Apoptosis through Mitochondria Dysfunction in Multiple Myeloma Cells (RPMI8226). · Asian Pacific journal of cancer prevention : APJCP