Question 1

How does Agrimonia pilosa work to stop bleeding?

Accepted Answer

Agrimonia pilosa exerts its hemostatic effects primarily through its high tannin content, which causes vasoconstriction and protein precipitation to help seal bleeding vessels. The herb also contains agrimonolide and flavonoids like luteolin and quercetin, which contribute to its astringent and anti-inflammatory properties. These compounds work together to promote blood clotting and reduce hemorrhage. Evidence level: C, based on in vitro and animal studies demonstrating hemostatic activity.

Question 2

Does Agrimonia pilosa interact with blood thinners or other medications?

Accepted Answer

Due to its hemostatic properties, Agrimonia pilosa may theoretically interact with anticoagulant medications such as warfarin, heparin, or antiplatelet drugs like aspirin and clopidogrel. The herb's ability to promote clotting could counteract the effects of these medications, potentially increasing thrombosis risk. Additionally, the high tannin content may reduce absorption of certain medications if taken concurrently. Patients on blood thinners should consult a healthcare provider before using this herb. Evidence level: C, based on pharmacological understanding.

Question 3

What is the standard dosage of Agrimonia pilosa for adults?

Accepted Answer

The traditional dosage for Agrimonia pilosa is 9-15 grams of dried herb prepared as a decoction (boiled in water). This range is based on Traditional Chinese Medicine practice and pharmacopoeial standards. The herb is typically divided into two or three doses throughout the day. For topical applications on wounds or bleeding, concentrated decoctions may be used externally. Due to limited clinical trial data, dosing should be guided by a qualified practitioner. Evidence level: Traditional/C.

Question 4

Is Agrimonia pilosa safe to take during pregnancy?

Accepted Answer

Agrimonia pilosa is considered unsafe during pregnancy and should be avoided. The herb's strong hemostatic properties and potential uterine effects pose risks to fetal development and pregnancy outcomes. Traditional contraindications explicitly list pregnancy as a condition where high doses should be avoided. Women who are pregnant or trying to conceive should not use this herb without explicit guidance from a qualified healthcare provider. Evidence level: C, based on traditional use and pharmacological properties.

Question 5

What conditions is Agrimonia pilosa used to treat?

Accepted Answer

Agrimonia pilosa is used in Traditional Chinese Medicine primarily for bleeding conditions, including hemoptysis, hematemesis, and traumatic bleeding. It is also employed for intestinal parasitic infections, particularly roundworm and tapeworm. Additional traditional uses include digestive complaints such as diarrhea and dysentery, as well as antibacterial applications for wound healing. The herb's astringent properties make it valuable for conditions involving fluid leakage or hemorrhage. Evidence level: C, based primarily on traditional use and limited preclinical research.

Agrimonia pilosa

Sources & Citations

Cipó Mil Homens

Temulawak

Salvia verbenaca

Summary

Background

Traditional uses

Active compounds

Mechanism of action

Clinical evidence

Safety & adverse effects

Evidence summary

PubMed sources

Government sources