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Allium Cepa Herb
Allium cepa
respiratory remedy for coughs in European folk medicine
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Allium cepa (onion) is a globally consumed vegetable with recognized nutritional and medicinal benefits [PMID:38455126], possessing a wide range of pharmacological properties including antioxidant and antimicrobial effects [PMID:30040448].
Background
Allium cepa L. is a member of the Amaryllidaceae family and is one of the most widely distributed species within the Allium genus [PMID:38262524, PMID:34400937]. It is cultivated worldwide across Europe, North America, Asia, and Africa [PMID:24915405].
Traditional uses
Onion has been used since antiquity in various indigenous cultures to manage ailments including microbial infections, respiratory, gastrointestinal, skin and cardio-vascular disorders, diabetes, renal colic, rheumatism, sexual impotence, menstrual pain, and headache [PMID:38262524].
Active compounds
Key bioactive constituents include flavonoids (quercetin, kaempferol, and quercetin derivatives), organosulfur compounds (allicin, diallyl disulphide, diallyl trisulphide, thiosulphinates, and ALK(EN)-based cysteine sulfoxides), phenolic acids, polysaccharides, and saponins [PMID:34400937, PMID:34368207, PMID:33643564, PMID:24915405].
Mechanism of action
Bioactive components of Allium cepa exhibit mechanisms such as free-radical scavenging, antioxidant activity, anti-inflammatory effects, chelating agent activity, and cytoprotective activities, which help reduce lipid peroxidation and increase protein synthesis in damaged tissues [PMID:34400937].
Clinical evidence
Evidence CDiabetes/Blood Sugar Management
Onion and its constituents are suggested to have anti-diabetic effects and the ability to manage blood sugar levels [PMID:38807798, PMID:30040448].
Evidence CCardiovascular Health
Reported benefits include antiplatelet activity, antithrombotic activity, and the ability to lower cholesterol and blood pressure [PMID:24915405, PMID:38807798].
Evidence CInflammatory and Respiratory Disorders
Suggested effectiveness in treating asthma, inflammatory disorders, and relieving coughs and colds [PMID:34567150, PMID:38807798].
Evidence CCancer
Compounds such as quercetin show promise in cancer prevention and anticancer properties [PMID:24915405, PMID:38807798].
Safety & adverse effects
Handling onion can induce contact dermatitis, rhinoconjunctivitis, and asthma [PMID:30858787]. Rare cases of IgE-dependent anaphylaxis following ingestion have been reported [PMID:30858787].
Evidence summary
The evidence is primarily based on reviews and preclinical (in-vitro/animal) studies (Level C and D), indicating broad pharmacological potential, though high-level clinical trial data (Level A/B) is lacking in the provided abstracts.
PubMed sources
1.PMID: 38455126 (2024) — Onion (Allium cepa L.) and Drought: Current Situation and Perspectives. · Scientifica
2.PMID: 38262524 (2024) — An ethnopharmacological, phytochemical, and pharmacological overview of onion (Allium cepa L.). · Journal of ethnopharmacology
3.PMID: 24915405 (2015) — Onion: nature protection against physiological threats. · Critical reviews in food science and nutrition
4.PMID: 30858787 (2019) — Immunological characterization of onion (Allium cepa) allergy. · Postepy dermatologii i alergologii
5.PMID: 34400937 (2021) — Onion (Allium cepa) and its Main Constituents as Antidotes or Protective Agents against Natural or Chemical Toxicities: A Comprehensive Review.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
· Iranian journal of pharmaceutical research : IJPR
6.PMID: 34953395 (2022) — Onion (Allium cepa L.) peels: A review on bioactive compounds and biomedical activities. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
7.PMID: 34567150 (2021) — Pharmacological Properties of Allium cepa, Preclinical and Clinical Evidences; A Review. · Iranian journal of pharmaceutical research : IJPR
8.PMID: 30040448 (2019) — Traditional and modern uses of onion bulb (Allium cepa L.): a systematic review. · Critical reviews in food science and nutrition
9.PMID: 38807798 (2024) — Quantification of the Anti-diabetic Effect of Allium cepa. · Cureus
10.PMID: 34368207 (2021) — Recent Advances in Bioactive Compounds, Health Functions, and Safety Concerns of Onion (Allium cepa L.). · Frontiers in nutrition
11.PMID: 33643564 (2021) — The effects of Allium cepa L. (onion) and its active constituents on metabolic syndrome: A review. · Iranian journal of basic medical sciences