PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Aqueous extracts and the compound ericifolin inhibit tumor cell proliferation and colony formation by silencing the androgen receptor [PMID:23568956, PMID:17986787]
Polyphenol-rich aqueous extract reduces viability and clonogenic growth of human breast cancer cells via autophagy [PMID:25945840]
Allspice essential oil reduces ear inflammation by more than 65%, with enhanced activity when combined with sweet orange peel and cumin [PMID:35844370]
Water and ethanol extracts dose-dependently inhibited the binding of SARS-CoV-2 spike protein to ACE2 [PMID:40032448]
Essential oil and eugenol showed efficacy in BALB/c mice after intralesional administration [PMID:38256897]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 23140298 (2012) — Medicinal properties of the Jamaican pepper plant Pimenta dioica and Allspice. · Current drug targets
- 2.PMID: 38736983 (2024) — Discovery of bitter masking compounds from Allspice (Pimenta dioica) using sensory guided isolation. · Food chemistry: X
- 3.PMID: 11237173 (2000) — Phenolic antioxidants from herbs and spices. · BioFactors (Oxford, England)
- 4.PMID: 21246442 (2011) — Composition and antioxidant activity of essential oil of pimento (Pimenta dioica (L) Merr.) from Jamaica. · Natural product research
- 5.PMID: 35844370 (2022) — Natural essential oil mix of sweet orange peel, cumin, and allspice elicits anti-inflammatory activity and pharmacological safety similar to non-steroidal anti-inflammatory drugs.