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Anise Green
Pimpinella anisum
Digestive conditions and colic since ancient Egypt
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Pimpinella anisum (Anise) is a medicinal herb used for its antimicrobial, gastroprotective, and galactagogue properties [PMID:30000835, 37446993, 17373749].
Background
Anise (Pimpinella anisum L.) is an aromatic plant widely used in folk medicine, pharmacy, and the food industry [PMID:22926042, 38334183].
Traditional uses
It has been used in folk medicine as an antiulcer, anticancer, antibacterial agent, and muscle relaxant [PMID:32145331].
Active compounds
The primary bioactive compound is trans-anethole [PMID:27427817, 37446993, 26619825]. Other constituents include chlorogenic acid, naringenin, gallic acid, ellagic acid, taxifolin, coffeic acid, syringic acid, eugenol, cis-anethole, methylchavicol, anisaldehyde, estragole, anisketone, linalool, coumarins, catechins, scopeletin, umbelliferone, estrols, beta-farnesene, limonene, and alpha-pinene [PMID:30000835, 37446993].
Mechanism of action
Anethole and polyphenols are noted to modulate intestinal motility and provide antimicrobial activity [PMID:39770978]. In rat models, Pimpinella anisum seeds attenuate colorectal cancer via antioxidant, anti-inflammatory, and anti-apoptotic pathways [PMID:38103135].
Clinical evidence
Evidence ABreast milk volume
A meta-analysis indicated a small increase in milk volume on day 1 postpartum, with low certainty evidence for an increase on day 7 [PMID:30000835]. A randomized controlled trial also reported a statistically significant difference in milk volume between intervention and placebo groups across several days [PMID:36681821].
Evidence BGastrointestinal symptoms of COVID-19
Evaluated as an add-on therapy using 25g of powdered aniseed twice daily for 2 weeks in a randomized, placebo-controlled trial [PMID:38292939].
Evidence DGastric ulcers (Animal model)
Aqueous suspension significantly inhibited gastric mucosal damage induced by necrotizing agents and indomethacin in rats [PMID:17373749].
Evidence DDiabetic wound healing (Animal model)
A 10% methanolic extract significantly decreased wound size and improved fibroblast numbers in diabetic rats [PMID:31600102].
Safety & adverse effects
Aniseed can cause clinical allergy, including occupational rhinoconjunctivitis and gastrointestinal symptoms [PMID:12027075]. In fish models, concentrations above 100 mg L-1 caused 10% mortality [PMID:38630160].
Pregnancy & lactation
Maternal ingestion reportedly imparts an odor to breastmilk, possibly due to anethole excretion [PMID:30000835]. In term-pregnant rats, extracts attenuated spontaneous and agonist-induced uterine contractions [PMID:32145331].
Drug interactions
In mice, aniseed essential oil significantly decreased the peak plasma concentration of acetaminophen after oral application [PMID:26619825]. It also significantly increased the analgesic effect of codeine and enhanced motor impairment caused by midazolam [PMID:22926042].
Evidence summary
Evidence ranges from high-level meta-analyses and RCTs regarding lactation to preclinical animal studies for gastroprotection and wound healing; human clinical data for other indications are limited.
PubMed sources
1.PMID: 30000835 (2006) — Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria. · Microorganisms
2.PMID: 38103135 (2024) — Anise (Pimpinella anisum L.) attenuates azoxymethane-induced colorectal cancer by antioxidant, anti-inflammatory, and anti-apoptotic pathways in rats. · Environmental science and pollution research international
3.PMID: 37446993 (2023) — Pimpinella anisum L. Essential Oil a Valuable Antibacterial and Antifungal Alternative. · Plants (Basel, Switzerland)
4.PMID: 39770978 (2024) — Herbal Extracts Mixed with Essential Oils: A Network Approach for Gastric and Intestinal Motility Disorders. · Nutrients
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
· Dermatitis : contact, atopic, occupational, drug
6.PMID: 26619825 (2016) — Pharmacokinetic Herb-Drug Interaction between Essential Oil of Aniseed (Pimpinella anisum L., Apiaceae) and Acetaminophen and Caffeine: A Potential Risk for Clinical Practice. · Phytotherapy research : PTR
7.PMID: 38292939 (2024) — Efficacy and safety of aniseed powder for treating gastrointestinal symptoms of COVID-19: a randomized, placebo-controlled trial. · Frontiers in pharmacology
8.PMID: 22926042 (2012) — The influence of essential oil of aniseed (Pimpinella anisum, L.) on drug effects on the central nervous system. · Fitoterapia
9.PMID: 31600102 (2019) — Wound healing activity of Pimpinella anisum methanolic extract in streptozotocin-induced diabetic rats. · Journal of wound care
10.PMID: 17373749 (2007) — Aqueous suspension of anise "Pimpinella anisum" protects rats against chemically induced gastric ulcers. · World journal of gastroenterology
11.PMID: 38630160 (2024) — Efficacy of fennel (Foeniculum vulgare) and anise (Pimpinella anisum) essential oils as anaesthesics in common carp (Cyprinus carpio L. 1758). · Fish physiology and biochemistry
12.PMID: 36681821 (2023) — The effect of Pimpinella Anisum herbal tea on human milk volume and weight gain in the preterm infant: a randomized controlled clinical trial. · BMC complementary medicine and therapies
13.PMID: 32145331 (2020) — Pimpinella anisum extract attenuates spontaneous and agonist-induced uterine contraction in term-pregnant rats. · Journal of ethnopharmacology
14.PMID: 12027075 (2002) — Occupational rhinoconjunctivitis and food allergy because of aniseed sensitization. · Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology