PubMed-compiled information sheet
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Compiled from 25 PubMed articles · model: gemma4:31b
Summary
Anthemis cotula, also known as mayweed chamomile or dog fennel, is a globally invasive annual plant [PMID:34466213, PMID:38694109]. It is recognized as a significant sensitizer capable of causing allergic contact dermatitis [PMID:3581826].
Background
Anthemis cotula (family Asteraceae) is a globally invasive, troublesome annual weed found in regions including the Pacific Northwest of the USA and the Kashmir Valley in India [PMID:34466213]. It is also referred to as stinking chamomile [PMID:31121457].
Active compounds
The plant contains sesquiterpene lactones, specifically anthecotuloide (also referred to as anthecotulide) [PMID:31121457, PMID:20603773, PMID:12926279, PMID:15787453]. Phenolic compounds identified include caffeoyl quinic acid, quercetin, and kaempferol derivatives [PMID:31121457].
Mechanism of action
Sesquiterpene lactones from A. cotula have demonstrated the ability to inhibit NF-κB DNA binding activity [PMID:20603773].
Clinical evidence
Evidence DAllergic Contact Dermatitis
A. cotula (dog fennel) was found to be one of the most frequent positive results in patch testing for patients with allergic contact dermatitis to wild vegetation [PMID:3581826].
Evidence DMicrobial Infection
A flavonoid-containing total extract of A. cotula flowers showed antimicrobial activity against both Gram-negative and Gram-positive microorganisms at a concentration of 200 microg/ml [PMID:11077183].
Safety & adverse effects
Anthemis cotula is a known allergen; it has been identified as a frequent sensitizer in patients with allergic contact dermatitis [PMID:3581826]. In one case report of a child with Compositae dermatitis, patch tests for A. cotula were negative [PMID:3827282].
Evidence summary
The available evidence is primarily based on phytochemical analysis, botanical studies of invasiveness, and dermatological patch testing (Level D). There are no clinical trials or systematic reviews provided.
PubMed sources
- 1.PMID: 34466213 (2021) — Genetic diversity and population structure of a global invader Mayweed chamomile (Anthemis cotula): management implications. · AoB PLANTS
- 2.PMID: 38694109 (2024) — Uncovering the secret weapons of an invasive plant: The endophytic microbes of Anthemis cotula. · Heliyon
- 3.PMID: 3581826 (1987) — Sensitivity to wild vegetation. · Contact dermatitis
- 4.PMID: 31121457 (2019) — Influence of different extraction techniques on the chemical profile and biological properties of Anthemis cotula L.: Multifunctional aspects for potential pharmaceutical applications. · Journal of pharmaceutical and biomedical analysis
- 5.PMID: 3827282 (1987) — Compositae dermatitis in childhood.