PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Deoxypodophyllotoxin and other petroleum ether fraction isolates show antitumor and antiproliferative activity against breast cancer (MCF7, MDA-MB-231), hepatocellular carcinoma (HepG2), osteosarcoma (MG-63), melanoma (B16), and cervical carcinoma (HeLa) cells in vitro [PMID:23818925, PMID:24761904, PMID:26287153].
Root extracts attenuated mucus secretion, inflammatory cell infiltration, and Th2 cytokine levels in OVA-induced asthma mouse models [PMID:30552991]. A fermented extract mixture containing A. sylvestris decreased coughs in guinea pigs and reduced lung inflammation in mice [PMID:34393544].
Oral administration of deoxypodophyllotoxin (5 and 10 mg/kg) decreased lipid accumulation in the liver of high-fat diet-induced C57BL/6 mice [PMID:30148990].
Root polysaccharides (AP) demonstrated in vivo anti-aging activity in D-gal-induced aging mice by boosting antioxidant enzymes and mitigating immune decline [PMID:39233161].
Aqueous leaf extracts inhibited LPS-induced secretion of nitric oxide and prostaglandin E2 in RAW264.7 cells and attenuated inflammatory mediators (TNF-alpha, IL-1beta, IL-6) [PMID:29377739].
Evidence summary
PubMed sources
- 1.PMID: 38674496 (2024) — Anthriscus sylvestris-Noxious Weed or Sustainable Source of Bioactive Lignans? · Plants (Basel, Switzerland)
- 2.PMID: 37948767 (2023) — Anthriscus sylvestris Deoxypodophyllotoxin Synthase Involved in the Podophyllotoxin Biosynthesis. · Plant & cell physiology
- 3.PMID: 34560578 (2021) — Comprehensive study of Anthriscus sylvestris lignans. · Phytochemistry
- 4.PMID: 39233161 (2024) — Structural characterization, anti-aging activity and mechanisms investigation in vivo of a polysaccharide from Anthriscus sylvestris. · International journal of biological macromolecules
- 5.PMID: 36144804 (2022) — Quantitative HPLC-UV Study of Lignans in Anthriscus sylvestris.