PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Sesquiterpenes (compounds 7, 10, 14, 15, and 21) significantly inhibited nitric oxide production in BV-2 microglial cells [PMID:26304765]
A 2-(2-phenylethyl)chromone showed neuroprotective activities against glutamate-induced and corticosterone-induced neurotoxicity in P12 pheochromocytoma and human U251 glioma cells, increasing cell viability by 82.2% and 86.9% respectively [PMID:22243963]
Abietane diterpenoid (compound 1) demonstrated antidepressant activity in vitro by inhibiting norepinephrine reuptake in rat brain synaptosomes by 81.4% [PMID:23394318]
Compounds 2, 8, 10, and 11 (2-(2-phenylethyl)chromones) exhibited strong ABTS•+ radical scavenging activity [PMID:31056992]
Evidence summary
PubMed sources
- 1.PMID: 26304765 (2015) — Anti-neuroinflammatory sesquiterpenes from Chinese eaglewood. · Fitoterapia
- 2.PMID: 37175310 (2023) — An Enantiospecific Synthesis of 5-epi-α-Bulnesene. · Molecules (Basel, Switzerland)
- 3.PMID: 22243963 (2012) — 2-(2-phenylethyl)chromones from Chinese eaglewood. · Phytochemistry
- 4.PMID: 31056992 (2020) — Antioxidative 2-(2-phenylethyl)chromones in Chinese eaglewood from Aquilaria sinensis. · Journal of Asian natural products research
- 5.PMID: 32990292 (2021) — Natural products in agarwood and Aquilaria plants: chemistry, biological activities and biosynthesis. · Natural product reports