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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Aralia elata is a perennial woody plant of the Araliaceae family used in East Asian traditional medicine for its pharmacological effects [PMID:35300010, PMID:37916310].
Background
Aralia elata (also known as Aralia mandshurica) is a woody plant species found in Northeastern Asia, particularly in China, Japan, and Korea [PMID:37916310, PMID:38485062]. It is closely related to Panax ginseng and is utilized as both a medicinal herb and a wild edible vegetable [PMID:39632860, PMID:42294140].
Traditional uses
In traditional Chinese medicine, it is used to 'tonify Qi and calm the mind, strengthen the essence and tonify the kidneys, and dispel wind and invigorate blood circulation' [PMID:37916310]. It has been used to treat neurasthenia, Yang deficiency, Qi deficiency, kidney Qi deficiency, spleen Yang deficiency, water-dampness stagnation, thirst, bruises, diabetes, rheumatoid arthritis, asthma, cough, and phlegm [PMID:37916310, PMID:33438534, PMID:39122067, PMID:41786057].
Active compounds
The primary active components are triterpenoid saponins (including elatosides and araloside A), polysaccharides (composed of Gal, Glc, Man, Ara, and Rha), and flavonoids [PMID:37916310, PMID:37436646, PMID:39122067, PMID:39731422, PMID:42294140]. Flower essential oil (AESFEO) also contains bioactive components [PMID:39204353].
Mechanism of action
Araloside A induces autophagy via a Raf/MEK/ERK-dependent manner to clear APP, total Tau, phosphorylated Tau, and α-synuclein [PMID:40742404]. Total saponins may alleviate myocardial ischemia-reperfusion injury by promoting NLRP3-inflammasome inactivation via PI3K/Akt signaling [PMID:36408810]. Flower essential oil promotes proliferation and type IV collagen production in keratinocytes by enhancing phosphorylation of Erk1/2, p38 MAPK, JNK, and Akt [PMID:39204353].
Clinical evidence
Evidence DMyocardial Ischemia-Reperfusion Injury
Total saponins (TSAE) alleviate injury by promoting NLRP3-inflammasome inactivation via PI3K/Akt signaling in rat models [PMID:36408810]
Evidence DNeurodegenerative Pathology (AD/PD)
Araloside A (ARA) promotes autophagosome formation and reduces cytotoxicity in neuronal cell and C. elegans models [PMID:40742404]
Evidence DSkin Wound Healing/Whitening
Flower essential oil (AESFEO) promotes keratinocyte proliferation and reduces melanin synthesis in B16BL6 cells [PMID:39204353]
Evidence DAsthma
Total glycosides (GA) show potential in ameliorating airway inflammation and mucus hypersecretion in asthmatic mice [PMID:41786057]
The current evidence consists primarily of in vitro cell studies, animal models, and literature reviews. There are no human clinical trials provided in the abstracts.
PubMed sources
1.PMID: 36387605 (2023) — Cut-dip-budding delivery system enables genetic modifications in plants without tissue culture. · Innovation (Cambridge (Mass.))
2.PMID: 37916310 (2023) — Research progress in pharmacological effects of Aralia elata. · Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
3.PMID: 37436646 (2023) — New biofunctional effects of oleanane-type triterpene saponins. · Journal of natural medicines
4.PMID: 39204353 (2024) — Potential Wound Healing and Anti-Melanogenic Activities in Skin Cells of Aralia elata (Miq.) Seem. Flower Essential Oil and Its Chemical Composition. · Pharmaceutics
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Aralia elata var. mandshurica (Rupr. & Maxim.) J.Wen: An overview of pharmacological studies.
· Phytomedicine : international journal of phytotherapy and phytopharmacology
6.PMID: 27859496 (2017) — Application of a solvent-free solid injection technique coupled with GC-MS for discrimination between the secondary metabolites of wild and cultivated South Korean medicinal foods. · Biomedical chromatography : BMC
7.PMID: 39632860 (2024) — Cytogenomic evaluation of regenerated Aralia elata using PLOP-FISH and flow cytometry. · Scientific reports
8.PMID: 33438534 (2021) — A Review on a Medicinal and Edible Plant: Aralia elata (Miq.) Seem. · Mini reviews in medicinal chemistry
9.PMID: 42294140 (2026) — Characterization of saponin biotransformation driven by intrinsic proteins in Aralia elata leaves. · Food chemistry: X
10.PMID: 39122067 (2024) — A mini-review of isolation, purification, structural characteristics and bioactivities of polysaccharides from Aralia elata (Miq.) Seem. · International journal of biological macromolecules
11.PMID: 35300010 (2022) — A High-Quality Reference Genome Sequence and Genetic Transformation System of Aralia elata. · Frontiers in plant science
12.PMID: 40742404 (2025) — Araloside A Induces Raf/MEK/ERK-Dependent Autophagy to Mitigate Alzheimer's and Parkinson's Pathology in Cellular and C. elegans Models. · Molecular neurobiology
13.PMID: 38485062 (2024) — A comprehensive analysis integrating phenotypic assessment uncovering thornless cultivar lineages in Aralia elata. · Genomics
14.PMID: 39731422 (2025) — Extraction and biological activities of polysaccharides and saponins from Aralia elata: a review. · Natural product research
15.PMID: 41786057 (2026) — Ameliorative effects of total glycosides from Aralia elata on airway inflammation and mucus hypersecretion in asthmatic mice. · Journal of ethnopharmacology
16.PMID: 36408810 (2023) — Total saponins of Aralia elata (Miq.) Seem. alleviate myocardial ischemia-reperfusion injury by promoting NLRP3-inflammasome inactivation via PI3K/Akt signaling. · The Kaohsiung journal of medical sciences
17.PMID: 38360127 (2024) — Functional identification of AeHMGR gene involved in regulation of saponin biosynthesis in Aralia elata. · Gene