PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
SSP demonstrated therapeutic potential in mice by inhibiting TLR4-mediated microglial activation [PMID: 41288786]
SSP attenuated lens opacification in ex vivo rat lenses and improved cell viability in human lens epithelial B3 cells by regulating Nrf2-mediated antioxidant responses [PMID: 41297623]
SSP improved lens opacity and alleviated endoplasmic reticulum stress-mediated apoptosis in rat models and HLEB3 cells [PMID: 39863224]
SSP alleviated hepatic injury and reduced heavy metal accumulation in mice and L02 hepatocytes via the Nrf2 pathway [PMID: 35367820, 35534262]
SSP showed protective effects in mice via the Nrf2/HO-1 signaling pathway and interference with arachidonic acid metabolism [PMID: 33027743]
Evidence summary
PubMed sources
- 1.PMID: 41288786 (2025) — Sagittaria Sagittifolia Polysaccharide Ameliorates Diabetic Retinopathy in Mice via Inhibiting TLR4-Mediated Microglial Activation. · Molecular neurobiology
- 2.PMID: 29374598 (2018) — Transcriptome analysis of starch and sucrose metabolism across bulb development in Sagittaria sagittifolia. · Gene
- 3.PMID: 32846537 (2020) — Purification, characterization, antioxidant and immunological activity of polysaccharide from Sagittaria sagittifolia L. · Food research international (Ottawa, Ont.)
- 4.PMID: 41297623 (2026) — Sagittaria sagittifolia polysaccharide regulates Nrf2-mediated antioxidant to improve apoptosis and ferroptosis in high glucose-induced lens epithelial cells. · Experimental cell research
- 5.PMID: 35367820