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PubMed · Bioprospecting <i>Artemisia roxburghiana</i> Wall. ex Besser extracts for their potential antimicrobial, antiprotozoal, antidiabetic and anticancer potential. (2025)
PubMed · A new guaianolide from Artemisia roxburghiana. (2013)
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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 13 PubMed articles · model: gemma4:31b
Summary
Artemisia roxburghiana is a medicinal herb found in high-altitude regions of the Himalayas and other areas, traditionally used to treat diabetes and various infections [PMID:39665106, 40024454].
Background
Artemisia roxburghiana is a herbaceous plant that serves as a dominant genus in the alpine ecosystems of the cold desert region in the Western Himalayas, specifically the Nelang Valley [PMID:39665106]. It is also found in Vietnam and northern Punjab, Pakistan [PMID:23432134, 26691254].
Traditional uses
In the Himalayan region, it is used as a remedy for fever, diabetes, malaria, dysentery, rheumatism, and viral hepatitis [PMID:40024454]. It is also used in the Indian subcontinent for the management of diabetes mellitus [PMID:33331175].
Active compounds
The plant contains terpenoids, glycosides, tannins, saponins [PMID:41404792], and artemisinins [PMID:41404792]. Specific isolated compounds include betulinic acid, betulin, taraxeryl acetate [PMID:26118418], 11-epi-8α-hydroxyarborescin, (24R)- and (24S)-cycloart-25-en-3b,24-diols, palmitic acid, and 1-octacosanol [PMID:23432134]. It also exhibits high total phenol content (93.4 ± 0.53 µg GAE/mg) and total flavonoid content (23.22 ± 0.23 µg CE/mg) [PMID:41844424].
Mechanism of action
The herb exhibits antidiabetic activity by inhibiting α-glucosidase and α-amylase enzymes [PMID:33331175]. Certain triterpene inhibitors (betulinic acid, betulin, and taraxeryl acetate) act as protein tyrosine phosphatase 1B (PTP1B) inhibitors, interacting with Gly220, Cys215, Gly218, and Asp48 [PMID:26118418].
Clinical evidence
Evidence DDiabetes Mellitus
Aqueous-ethanol extract of aerial parts showed a significant glucose-lowering effect in streptozotocin-nicotinamide-induced diabetic Wistar rats at doses of 200 and 400 mg/kg [PMID:33331175].
Evidence DGastrointestinal Nematodes
Methanolic extracts showed maximum anthelmintic activity at a concentration of 50 mg/ml in an in vitro egg hatch inhibition assay [PMID:26691254].
Evidence DMalaria/Protozoal Infections
Extracts demonstrated antimalarial activity (IC50=18.76 ± 1.80 µg/mL) and general antiprotozoal activity [PMID:41404792, 21527328].
Safety & adverse effects
Acute and sub-acute toxicity was evaluated in albino mice using aqueous leaf extract; however, the provided abstract does not list specific adverse findings, only the parameters assessed (body weight, hematological, and biochemical parameters) [PMID:40024454].
Evidence summary
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating potential antidiabetic, antimicrobial, and anthelmintic activities.
PubMed sources
1.PMID: 39665106 (2024) — Floristic diversity and species composition along altitudinal gradient in the alpine ecosystem of the cold desert region in Western Himalaya, India. · Frontiers in plant science
2.PMID: 41404792 (2025) — Bioprospecting Artemisia roxburghiana Wall. ex Besser extracts for their potential antimicrobial, antiprotozoal, antidiabetic and anticancer potential. · Natural product research
3.PMID: 26118418 (2016) — Protein tyrosine phosphatase 1B inhibitors isolated from Artemisia roxburghiana. · Journal of enzyme inhibition and medicinal chemistry
4.PMID: 23432134 (2013) — A new guaianolide from Artemisia roxburghiana. · Natural product research
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Antidiabetic effect of aqueous-ethanol extract from the aerial parts of Artemisia roxburghiana.
· Natural product research
6.PMID: 21527328 (2011) — Antiprotozoal activities of traditional medicinal plants from the Garhwal region of North West Himalaya, India. · Journal of ethnopharmacology
7.PMID: 40024454 (2025) — Toxicological assessment of standardized Artemisia roxburghiana wall. ex Besser aqueous leaf extract to acute and subacute exposure in Albino mice. · Journal of ethnopharmacology
8.PMID: 26691254 (2015) — Anthelmintic properties of extracts from Artemisia plants against nematodes. · Tropical biomedicine
9.PMID: 41844424 (2026) — Synthesis and characterization of zinc oxide nanoparticles by the aerial part of Artemisia roxburghiana extract and assessment of their biological activities. · Zeitschrift fur Naturforschung. C, Journal of biosciences
10.PMID: 21047440 (2010) — Survey of artemisinin production by diverse Artemisia species in northern Pakistan. · Malaria journal
11.PMID: 36081821 (2022) — Formulation and evaluation of SGLT2 inhibitory effect of a polyherbal mixture inspired from Ayurvedic system of medicine. · Journal of traditional and complementary medicine
12.PMID: 19143344 (2008) — Restoration potential of pioneer plants growing on lead-zinc mine tailings in Lanping, southwest China. · Journal of environmental sciences (China)
13.PMID: 14750205 (2004) — The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells. · Phytotherapy research : PTR