PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Aqueous extracts suppressed NO production and PGE2 synthesis by inhibiting iNOS and COX-2 mRNA expressions in macrophages [PMID:14993796].
70% ethanol extract of the rhizome significantly inhibited 5-LOX-catalyzed leukotrienes production in RBL-1 cells and was administered to hapten-treated NC/Nga mice [PMID:23212643].
A. japonica demonstrated protective effects against acetic acid-induced gastric ulcers in rats [PMID:38074916].
A fermented mixed extract containing A. japonica (Vigeo) protected against LPS-induced inflammatory bone loss in mice and suppressed RANKL-induced osteoclastogenesis in vitro [PMID:34836159].
Vigeo (containing A. japonica) attenuated cartilage and bone destruction in a collagen-induced arthritis mouse model [PMID:38590570].
Evidence summary
PubMed sources
- 1.PMID: 12576647 (2003) — Glycosides of Atractylodes japonica. · Chemical & pharmaceutical bulletin
- 2.PMID: 33176498 (2022) — Three new polyacetylenes from Atractylodes japonica Koidz.ez Kitam. · Natural product research
- 3.PMID: 38662303 (2024) — Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam. · Journal of natural medicines
- 4.PMID: 23212643 (2012) — Effects of the rhizomes of Atractylodes japonica and atractylenolide I on allergic response and experimental atopic dermatitis. · Archives of pharmacal research
- 5.PMID: 26919689 (2016) — Anti-inflammatory and Antinociceptive Constituents of Atractylodes japonica Koidzumi.