PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Pulsatilla Decoction and its saponins (PRS) demonstrate protective effects and alleviate colitis in murine models by modulating gut microbiota and inflammatory cytokines [PMID:38974042, PMID:36806339, PMID:41316147].
Pulsatilla saponin A and other extracts inhibit growth and induce apoptosis in hepatocellular carcinoma, pancreatic cancer, and lung carcinoma cells in vitro and in mouse xenograft models [PMID:24576780, PMID:40697880].
Pulsatilla chinensis saponins (PRS) ameliorated murine depression by inhibiting intestinal inflammation mediated by IDO1 overexpression [PMID:37167824].
Administration of P. chinensis in rats significantly reduced serum cholesterol and triglycerides [PMID:39696673].
Anemoside B4 ameliorated SALI by targeting RAGE and inhibiting ferroptosis in mouse models [PMID:40822455].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 35606807 (2022) — Pharmacological activities and molecular mechanisms of Pulsatilla saponins. · Chinese medicine
- 2.PMID: 32679180 (2020) — Therapeutic potential of triterpenoid saponin anemoside B4 from Pulsatilla chinensis. · Pharmacological research
- 3.PMID: 37167824 (2023) — Pulsatilla chinensis saponins ameliorated murine depression by inhibiting intestinal inflammation mediated IDO1 overexpression and rebalancing tryptophan metabolism. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 4.PMID: 8768325 (1996) — Triterpenoids from Pulsatilla chinensis. · Phytochemistry
- 5.PMID: 38974042 (2024) — Baitouweng decoction alleviates ulcerative colitis by regulating tryptophan metabolism through DOPA decarboxylase promotion.