PubMed-compiled information sheet
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Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Ban Xia Rhizome (Pinellia ternata) is a traditional East Asian medicinal herb used primarily for treating cough, vomiting, and inflammatory conditions [PMID:32798614, PMID:39855824].
Background
Pinellia ternata (Thunb.) Breit. is a perennial herb distributed in China and other East Asian regions, where its dried tuber (Pinelliae Rhizoma) is used as a medicinal drug [PMID:38058630, PMID:39855824].
Traditional uses
Traditionally used for 'removing dampness-phlegm', 'downbear counterflow and check vomiting', and dissipating masses [PMID:36087845, PMID:35988838]. It is also used to treat cough, infection, asthma, and inflammation [PMID:39855824].
Active compounds
The rhizome contains nucleoside alkaloids, cerebrosides, fatty acids, lectin, polysaccharides, and calcium oxalate crystals [PMID:36087845].
Mechanism of action
Pinellia ternata lectin (PTL) can induce inflammation by binding to Toll-like receptor 4 (TLR4), which activates the PI3K/Akt/mTOR and NF-κB pathways [PMID:36669722]. In the context of chemotherapy-induced nausea and vomiting (CINV), Xiao-Ban-Xia decoction may inhibit ferroptosis via activation of the Nrf2/SLC7A11/GPX4 pathway [PMID:39501722].
Clinical evidence
Evidence AChemotherapy-induced nausea and vomiting (CINV)
Pinellia ternata-containing TCM combined with 5-HT3RAs significantly improved the clinical effective rate (CER) of CINV [PMID:37099981].
Evidence DInsomnia
The Banxia-Xiakucao herb pair (BXHP) has demonstrated clinical efficacy in treating insomnia [PMID:38986753].
Evidence DHelicobacter pylori infection
The herb pair of Pinellia ternata and Coptidis Rhizoma has demonstrated clinical efficacy against H. pylori colonization [PMID:41389884].
Evidence summary
Evidence ranges from high-level systematic reviews and meta-analyses for CINV treatment to preclinical animal and cell-based studies for other inflammatory and metabolic conditions.
PubMed sources
- 1.PMID: 39501722 (2024) — Xiao-Ban-Xia Decoction Alleviates Chemotherapy-Induced Nausea and Vomiting by Inhibiting Ferroptosis via Activation of The Nrf2/SLC7A11/GPX4 Pathway. · Advanced biology
- 2.PMID: 36087845 (2022) — A review of traditional and current processing methods used to decrease the toxicity of the rhizome of Pinellia ternata in traditional Chinese medicine. · Journal of ethnopharmacology
- 3.PMID: 38058630 (2023) — A review of the research progress on Pinellia ternata (Thunb.) Breit.: Botany, traditional uses, phytochemistry, pharmacology, toxicity and quality control. · Heliyon
- 4.PMID: 41389884 (2026) — Pinellia ternata-Coptidis Rhizoma herb pair suppresses Helicobacter pylori colonization via NLRP3-mediated pyroptosis. · Journal of ethnopharmacology
- 5.PMID: 37311896 (2023) — Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber.