This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Benincasa hispida, also known as wax gourd or winter melon, is an Asian crop with significant economic and medicinal value used in traditional medicine for various neurological and metabolic conditions [PMID:36750625, 34925698].
Background
Benincasa hispida is an annual climbing plant of the Cucurbitaceae family native to Asia [PMID:34925698, 35328015]. It is the only species in the genus Benincasa [PMID:36750625].
Traditional uses
In traditional medicine, it has been used to treat neurological diseases, kidney disease, fever, cough with thick mucus, intestinal worms [PMID:34925698], obesity, ulcers, epilepsy, bleeding piles, hyperacidity, haemoptysis, dysuria, and urinary calculi [PMID:41485626]. The Ayurvedic system specifically uses the fruits to treat mental diseases, including schizophrenia [PMID:38541704]. The outer peel (Benincasae Exocarpium) is used to relieve thirst, promote diuresis, eliminate dampness, and clear heart fire [PMID:40544980].
Active compounds
Bioactive compounds include flavonoids, alkaloids, terpenoids, amino acids [PMID:40544980], tannins, phenolic acids, soluble fiber, and carbohydrates [PMID:36875430]. Specific identified compounds include rutin [PMID:37835208], 2-furoic acid, 2,3-dihydroxybenzoic acid, and rubinaphthin A in fermented forms [PMID:38370299].
Mechanism of action
B. hispida polysaccharides may activate the NRF2/HO-1 pathway to prevent H2O2-induced reactive oxygen species (ROS) production and apoptosis [PMID:35784722]. It may alleviate amyloid pathology by inhibiting the Keap1/Nrf2-axis [PMID:33932860]. Seed extracts exhibit anti-angiogenic properties by decreasing bFGF-induced endothelial cell proliferation and tube formation [PMID:15740888].
Clinical evidence
Evidence BType 2 Diabetes
A powdered drink containing 2.5 g of B. hispida extract significantly reduced diastolic blood pressure (Δ -7.0 mmHg) and showed a greater reduction in mean fasting plasma glucose compared to a control group [PMID:39282126]
Evidence DStress and Anxiety
Aqueous extract of B. hispida fruit reduced levels of stress and anxiety in a zebrafish model, increasing frequency of entry and duration in the bright section of tests [PMID:38541704]
Evidence DAlzheimer's Disease
Oral administration of fruit extract (250 and 500-mg/kg/day) in AlCl3-induced rats improved cognitive deficits and altered biochemical/neurochemical profiles [PMID:33932860]
Evidence DDiabetic Nephrotoxicity
Hydroalcoholic extract reinstates renal structural and functional dynamics in diabetic mice by modulating hyperglycemia-induced renal fibrosis and preventing podocyte loss [PMID:41485626]
Evidence DSalt-induced Hypertension
Extracts positively regulated high salt-induced hypertension in Dahl salt-sensitive rats [PMID:36314446]
Safety & adverse effects
Seed extract showed no cytotoxicity on HUVECs and normal fibroblast cells [PMID:15740888]. Peel extracts were not toxic to fibroblast cells [PMID:37835208].
Evidence summary
Evidence is primarily based on preclinical animal models (zebrafish, rats, mice) and in vitro cell studies (D), with one small-scale clinical intervention study (B) regarding type 2 diabetes. Review articles (C) support its traditional use and general pharmacological potential.
PubMed sources
1.PMID: 26448818 (2015) — Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity. · Oxidative medicine and cellular longevity
2.PMID: 38541704 (2024) — Benincasa hispida Alleviates Stress and Anxiety in a Zebrafish (Danio rerio) Model. · Life (Basel, Switzerland)
3.PMID: 36750625 (2023) — A chromosome-level reference genome of the wax gourd (Benincasa hispida). · Scientific data
4.PMID: 41485626 (2026) — Hydroalcoholic extract of Benincasa hispida (Thunb.) Cogn. reinstates renal structural and functional dynamics compromised in diabetic mice: molecular insights through integration of transcriptomics and proteomics. · Journal of ethnopharmacology
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Benincasae Exocarpium (BE) showed a moderate inhibitory effect on xanthine oxidase (IC50 = 720.6 μg/mL) and provided hepatoprotective and nephroprotective roles in rats [PMID:40544980]
Evidence DTriple Negative Breast Cancer
Seed extract demonstrated anti-proliferative properties, inducing apoptotic cell death and S-phase cell cycle arrest in vitro [PMID:40022691]
— Comparative Chloroplast Genome Analysis of Wax Gourd (Benincasa hispida) with Three Benincaseae Species, Revealing Evolutionary Dynamic Patterns and Phylogenetic Implications.
· Genes
6.PMID: 34925698 (2021) — A Literature-Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles. · Oxidative medicine and cellular longevity
7.PMID: 36314446 (2022) — Benincasa hispida extracts positively regulated high salt-induced hypertension in Dahl salt-sensitive rats: Impact on biochemical profile and metabolic patterns. · Journal of food biochemistry
8.PMID: 35784722 (2022) — Valorization of Polysaccharides From Benincasa hispida: Physicochemical, Moisturizing, and Antioxidant Skincare Properties. · Frontiers in pharmacology
9.PMID: 40544980 (2025) — Antihyperuricemic, hepatoprotective and nephroprotective roles of Benincasae Exocarpium in hyperuricemia rats. · Journal of ethnopharmacology
10.PMID: 36875430 (2023) — Ethnopharmacology, phytochemistry and pharmacology of Benincasae Exocarpium: A review. · Chinese herbal medicines
11.PMID: 42186149 (2026) — Effect of Lactiplantibacillus plantarum NCU001557 Fermentation on the Physicochemical Properties, Bioactivity, Volatile, and Nonvolatile Compounds of Benincasa hispida (Winter Melon) Juice. · Journal of food science
12.PMID: 37835208 (2023) — Influence of Benincasa hispida Peel Extracts on Antioxidant and Anti-Aging Activities, including Molecular Docking Simulation. · Foods (Basel, Switzerland)
13.PMID: 34659288 (2021) — Identification and Application of BhAPRR2 Controlling Peel Colour in Wax Gourd (Benincasa hispida). · Frontiers in plant science
14.PMID: 30728591 (2019) — Physicochemical and functional properties of ash gourd/bottle gourd beverages blended with jamun. · Journal of food science and technology
15.PMID: 38370299 (2024) — Identification of marker compounds in fermented Benincasa hispida and validation of the method for its analysis. · Food chemistry: X
16.PMID: 39658692 (2024) — Map-based cloning revealed BhAPRR2 gene regulating the black peel formation of mature fruit in wax gourd (Benincasa hispida). · TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
17.PMID: 31660838 (2021) — Medicinal Plants in the Treatment of Obsessive-Compulsive Disorder: A Review. · Current drug discovery technologies
18.PMID: 28887587 (2017) — A deletion of the gene encoding amino aldehyde dehydrogenase enhances the "pandan-like" aroma of winter melon (Benincasa hispida) and is a functional marker for the development of the aroma. · TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
19.PMID: 39903217 (2025) — Lyophilized ash gourd (Benincasa hispida (Thunb.) Cogn.) juice alleviates diet-induced prediabetes in a rat model. · Food & function
20.PMID: 33932860 (2021) — Benincasa hispida alleviates amyloid pathology by inhibition of Keap1/Nrf2-axis: Emphasis on oxidative and inflammatory stress involved in Alzheimer's disease model. · Neuropeptides
21.PMID: 34480584 (2021) — Fine mapping and identification of the candidate gene BFS for fruit shape in wax gourd (Benincasa hispida). · TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
22.PMID: 15740888 (2005) — Anti-angiogenic effect of the seed extract of Benincasa hispida Cogniaux. · Journal of ethnopharmacology
23.PMID: 36161030 (2022) — Genetic mapping and genome-wide association study identify BhYAB4 as the candidate gene regulating seed shape in wax gourd (Benincasa hispida). · Frontiers in plant science
24.PMID: 36226283 (2022) — Integrated analysis of multi-omics and fine-mapping reveals a candidate gene regulating pericarp color and flavonoids accumulation in wax gourd (Benincasa hispida). · Frontiers in plant science
25.PMID: 39282126 (2024) — Efficacy of a Benincasa hispida powdered drink in improving metabolic control in patients with type 2 diabetes: A placebo-controlled study. · International journal of health sciences
26.PMID: 36430500 (2022) — Genome-Wide Identification of the SAUR Gene Family in Wax Gourd (Benincasa hispida) and Functional Characterization of BhSAUR60 during Fruit Development. · International journal of molecular sciences
27.PMID: 36618646 (2022) — A transcriptome analysis of Benincasa hispida revealed the pathways and genes involved in response to Phytophthora melonis infection. · Frontiers in plant science
28.PMID: 24991093 (2014) — Revisiting "Vegetables" to combat modern epidemic of imbalanced glucose homeostasis. · Pharmacognosy magazine
29.PMID: 42026474 (2026) — Genome-wide identification and expression analysis of the ARF gene family in wax gourd (Benincasa hispida). · BMC plant biology
30.PMID: 40022691 (2025) — Evaluating the Efficacy of Benincasa Hispida Seed Extract in Inhibiting the Proliferation of a Human Triple Negative Breast Cancer Cell Line. · Asian Pacific journal of cancer prevention : APJCP