PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Treatment with black and fermented leaf extracts in rats reduced daily dietary intake by 40%, improved glucose tolerance, and significantly reduced serum triglyceride levels by 45% [PMID:23079230]
Leaf extracts showed inhibitory effects on Streptococcus mutans biofilms by decreasing bacterial viability and adherence [PMID:28955316]
Bergenin inhibits the growth of human cervical cancer cells [PMID:38961106]
Bergenan BC increased delayed type hypersensitivity (DTH) reactions in mice and enhanced human neutrophil uptake capacity [PMID:16372371]; dry extracts normalized antibody-forming cells in the spleen of mice under stress [PMID:16277213]
Ethanolic extracts demonstrated antimicrobial activity against various microorganisms, including Candida albicans [PMID:12169406, PMID:30700645]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 25442262 (2014) — Bergenia crassifolia (L.) Fritsch--pharmacology and phytochemistry. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 2.PMID: 23256653 (2012) — [Bergenia genus - content matters and biological activity]. · Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti
- 3.PMID: 36979338 (2023) — Chemistry and Pharmacology of Bergenin or Its Derivatives: A Promising Molecule. · Biomolecules
- 4.PMID: 40302673 (2025) — Effects of Mongolian Bergenia crassifolia L. (root) extract on rumen methane emission and microbial community. · Animal bioscience
- 5.PMID: 28955316 (2017)